Possible to be ER+ and PR- ?

Strike_Two · January 2013

I haven't seen my oncologist yet, and I'm reading my path report and it sure does look like ER+/PR-, HER-. Is that possible? Unusual? It seems like most women who are ER+ are also PR+.

Thanks if you can offer an insight.

weety · January 2013

I'm ER+ (weakly) and PR-.

ruthbru · January 2013

It's not that unusual. That's my diagnosis too.

pebee · January 2013

Mine too. There is a thread started with details about this subtype - I will bump it.

doxie · January 2013

Here is one thread on PR- that ended in Jan.

http://community.breastcancer.org/topic_post?forum_id=96&id=754610&page=1

My PR % is very low, but ER is high.

profbee · January 2013

I am pr-, er+, and Her2+

michellej1980 · January 2013

I've noticed that too, not sure whether it is a particularly positive or negative feature of BC.

Letlet · January 2013

Im sure its possible..im the opposite, er - and pr+

jacksnana · January 2013

This is my diagnosis also.

Melrosemelrose · January 2013

Here is mine ER +/ PR - HER2 +1 which is considered HER2 - in the Herceptin world.

I am receiving Herceptin only because I was randomized to receive it through the Herceptin B-47 clinical trial. But for that clinical trial, Herceptin would not be prescribed under the current treatment protocal.

pupmom · January 2013

One thing I've wondered about is, if one is ER+, PR-, is the amoung of ER usually low, relative to being ER/PR+?

doxie · January 2013

The recent research I've read indicates that ER is usually relatively low. In my case, my ER is 95% and PR 5%. PR registered as strongly negative in the Oncotype.

michellej1980 · January 2013

On my path report they used a different scoring system: ER 8/8, PR 0/8.

carlads · January 2013

I was originally diagnosed with my biopsy as TN, after my surgical pathology I do have some hormone receptors not high percentage but enough to take me off the TN list.. I have wondered if this has happened to anyone else?

Carla

MameMe · February 2013

Carlads, No, so far no change, but I am waiting for Oncotype for additional data. Can you ask that question again and get it to show up on today's posts? Just a thought.

ruthbru · February 2013

type the word 'bump' and it shows up on the recent posts again.

christina1961 · February 2013

Carla, I had a similar thing happen although I had neoadjuvant chemo. I had triple negative diagnosis at biopsy - less than 1% ER receptors. The pathologist at the time recommended retesting following surgery. After my mastectomy they discovered that the remaining tumor was 5-10% ER positive and I am now on tamoxifen. The oncologist said it was possible that the chemo mutated the tumor.

carlads · February 2013

Hi Ladies,

Thank you for your response.

christina19- I have heard that neoadjuvant chemo can change the hormone receptors. I didn't have chemo before surgery, I think they just didn't get enough tissue. What chemo cocktail did you have?

ruthbru- I always wonder why people would put -bump- now I know thank you I will try that.

Mameme- Keep us posted!

Strike_Two · February 2013

I am "highly" ER+ while PR-. My ER total was 97, while my PR total was 0.

My oncologist says that there is no difinitive answer to the question "How does this affect me?" Study results are mixed, so I'm thinking positive and believing that if being PR- was a truly bad thing, it would have shown up in some study by now.

Possible to be ER+ and PR- ?

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