San Antonio Breast Cancer Symposium 2012

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TectonicShift
TectonicShift Member Posts: 752
edited June 2014 in Stage III Breast Cancer

Started today. This thread is intended to be a place where the news from San Antonio is discussed

EDITED TO ADD:  Here is a link to the Press Releases page: http://sabcs.org/PressReleases/index.asp

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  • TectonicShift
    TectonicShift Member Posts: 752
    edited October 2014

    First good news out of San Antonio: fewer deaths among people who stay on Tamoxifen for 10 years vs 5 years

    About 3 fewer deaths per 100 patients followed from 5 to 14 years

    http://sabcs.org/PressReleases/Documents/2012/9957ec3ea6c7a19b.pdf

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  • hopefour
    hopefour Member Posts: 459
    edited December 2012

    Thank you tectonic shift for sharing this info with us...it truly helps me!

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  • cmdczc
    cmdczc Member Posts: 75
    edited December 2012

    Appreciate the link...  I had just remembered the meeting started this week.  Will be following closely.

    Cindy (stage IIIa)

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  • Momine
    Momine Member Posts: 7,859
    edited December 2012

    This is interesting:

    "The findings reveal no tumor advancement for a median of 26.1 months, compared with 7.5 months in those who received femara independently. The drug was in its second of three mandatory stages required for U.S. approval.

    PD 0332991 is the first in a new group of agents that functions by inhibiting a protein imperative to cancer cell cycle." http://www.medicalnewstoday.com/articles/253657.php

    I had just been reading yesterday about this protein connection and wondered when we might have a drug to address it. It would presumably also be relevant to stage III eventually, as another preventive drug in conjunction with hormone-suppression.

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  • clariceak
    clariceak Member Posts: 752
    edited December 2012

    I thought the info on tamox was interesting, especially since I was perimenopausal before I was dxed and was started on Femera.  Now I wonder if I should have been started on Tamox and then switched to Femera. 

    At least my onc doesn't have a end date for Femera.  I think as long as I'm alive I'll keep taking it.

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  • clariceak
    clariceak Member Posts: 752
    edited December 2012

    And then I read this. 

    SAN ANTONIO – For postmenopausal women with breast cancer, 5 years of adjuvant treatment with letrozole (Femara) outperformed tamoxifen over 8 years of follow-up, a researcher said.

    Women with estrogen receptor-positive and HER2-negative cancer did significantly better in both disease-free and overall survival if they took letrozole, according to Otto Metzger Filho, MD, of Dana-Farber Cancer Institute in Boston.

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  • Momine
    Momine Member Posts: 7,859
    edited December 2012

    Clarice, that is what my doc said too, that letrozole had an edge. Like you, I have a feeling I will be on femara a lot longer than 5 years. I checked, by the way, and my doc contributed at the conference.

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  • Pure
    Pure Member Posts: 1,796
    edited December 2012

    I wonder if it matters if you take the generic version? Does it have tobe Femara specifically.

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  • ck55
    ck55 Member Posts: 346
    edited December 2012

    I finished my 5 years on Femara in August. I wanted to stay on something and also wanted to do something about the extreme dryness "down south". So my onc and I decided I would go on Tamoxifen and use Vagifem for the dryness with the thought that any increase in systemic estrogen would be blocked by the Tamoxifen.

    I wounder how this scenario fits in with the statistics? I would guess I should continue the Tamoxifem for 5 years?

    Cyndi

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  • Kheng
    Kheng Member Posts: 26
    edited December 2012

    Hi Clarice



    According to a research by ASCO JOURNAL, Femara (Letrozole) cause heart attack and stroke

    Among 5000 patients, more than half suffers the above tragedies!



    You may wish to consider Anastrozole ;(Arimidex)



    Love and blessings from Singapore

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  • Momine
    Momine Member Posts: 7,859
    edited December 2012

    Kheng, who told you that? It is simply not true.

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  • Momine
    Momine Member Posts: 7,859
    edited December 2012

    http://www.pslgroup.com/dg/215672.htm

    "In a head-to-head worldwide study of the two leading aromatase inhibitors, data demonstrate that 50% more women respond to Femara® (letrozole tablets) than to Arimidex® (anastrozole) in advanced breast cancer."

    "Both Femara and Arimidex were generally well-tolerated and there were no statistically significant differences between treatment arms in reported frequencies of adverse events, including serious adverse events."

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  • Racy
    Racy Member Posts: 2,651
    edited December 2012

    Thank you Momine.

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