Luminal A BC?

I thought it also depended on your Ki67 index value to distinguish luminal A from luminal B cancers. I believe I've read that the cutoff is around a 14% Ki67 value - under 14% is luminal A (slower growing), over is luminal B. 

Here's the Research News report on the study, from the main Breastcancer.org site.

• The Mods

Cyndi, you are correct.  A mitotic rate of 1 should indicate a low ki67.  

According to my MO, mine is Luminal A. I am ER/PR+, HER2 -, Grade 2, mitotic score of 1. No ki67 score for me either, but he says, based on what we know, we can assume my cancer is Luminal A.

I'm not sure if lobular makes a difference. I don't think so. Maybe one of the lobular ladies will chime in with an answer to that question.

The 2012 NCCN (professional version) breast cancer treatment guidelines outlines on pages 93-98 the current research and all of the studies pertaining to endocrine therapy.  For those of you who are Luminal A, as Mamabee's physician stated, the risk, while low, might still be there, and longer use of endocrine therapy MIGHT be beneficial.  Check out the guidelines!  There's an eloquent discussion found on those pages!

Ok ladies -- anyone have all grades in their tumor ??? I did from a one to a three.  My onc said I am Luminal A group so am not sure how that is determined -- also am ER/PR+ and HER2 neg.  Does anyone's onc say the longer time NED you are, the risk of recurrence should drop or go down?  Sometimes we hear the risk is the same as in the first 5 yrs. 

voraciousreader, just wanted to thank you for the tip about the NCCN guidelines. Finally got a chance to read them - very interesting! Didn't know that resource was available online, but glad it is. I learned a lot.

Yes,

Genotyping should be done to calculate your risks-Luminal A and Luminal B are differences between low Ki-67 and high -67 with Luminal A having a prevelance rate of 42-59% versus Luminal B (more aggressive type) 6-19%

Basal is 14-20%

Her2 7-12%

I had grade 1, mitotic count of 1, tumor, er45% pr 45% with a ki67 of 18%. Apparently this is very rare with a low grade, my onc also said on a different day with a different technician I may have got a lower ki67!

So the ki67 puts me into luminal b but everything else says luminal a. Ki67 was the sole reason for my chemo, and had it been 14 I would not have been offered it.

Maggs, you can have ki67 done at MD Anderson. I had a pathology review done there, but i had to write a letter detailing what information i wanted and i had to call several times to get them to do the ki67. my insurance paid for this. 

i think this is the website:

http://www.mdanderson.org/patient-and-cancer-information/care-centers-and-clinics/clinics/second-opinion-pathology/index.html

i called and got some more information. then you have to get your slides shipped off from your hospital (you will probably need to contact your hospital's pathology department and sign some type of consent) and make sure you specify you want your surgery slides, not your biopsy slides! 

also, i asked my oncologist about whether i was A or B and he told me A because my ki67 was very low, mitotic rate was 1, high hormone sensitivity (though i was not 100%!). Im not sure if there is an exact test to determine this or if they just go based off of the information they have. i think with a high hormone sensitivity and low mitotic score, probably luminal A, but honestly i have no idea. this is just how i understood it when i read about luminal types. i also think her2+ tends to be luminal b.