For recently dx'd up to stage 3A low-Her2 in New England

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TectonicShift
TectonicShift Member Posts: 752
edited June 2014 in Stage III Breast Cancer

The phase 3 NeuVax vaccine trial is finally opening some sites in Massachusetts.

I'm not sure which stages are allowed but I think it's stage II and stage III. Also, I think you must be Her2 low -- meaning Her2 1+ or Her2 2+. (Those are both considered Her2 negative, not Her2 positive.) 

The results look promising so far. Good luck to anyone who gets in the trial!

http://clinicaltrials.gov/ct2/show/NCT01479244

Edited to add: Vaccine trials seem to let you enroll one to six months after the end of rads. Not sure if that's always the case.

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  • TectonicShift
    TectonicShift Member Posts: 752
    edited May 2014

    I'm bumping this thread. It's really important that we get these vaccine trials fully enrolled asap.

    There is also another vaccine trial (different one than the one listed above) going on for a vaccine called AE37. In this trial, you start AFTER you're done with standard of care treatment. You can be up to stage 3C. http://clinicaltrials.gov/ct2/show/NCT00524277?term=ae37+vaccine&rank=1

    For your newbies, please understand this. You do not have to necessarily switch oncs or switch hospitals to participate in a clinical trial at a different hospital. Some of the trials, maybe you do. But not necessarily. Each trial is different. And please understand this. Many oncs will only offer you trials that are being conducted at their own hospital or practice. You have to be proactive and look around for other trials you might want to be in and make the calls yourself.

    There are basically two main BC vaccines in trial right now: Neuvax vaccine (aka E75) and the AE37 vaccine. The Neuvax trials are a little farther along in their trials. Both look very promising in terms of reducing recurrence. There is also PanVac and another new one that is just recruiting for a phase 1 trial in Virginia: http://clinicaltrials.gov/ct2/show/NCT01532960?term=breast+cancer+vaccine&rank=1. 

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  • Momof2inME
    Momof2inME Member Posts: 683
    edited September 2012

    I too am in New England. I finish Herceptin in February and plan on starting the AE37 vaccine trial at Sibley in D.C. in March. I agree about getting more women involved. My onc really believes that these vaccine will be the future of BC tx and is very supportive of me doing the trial.

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  • TectonicShift
    TectonicShift Member Posts: 752
    edited September 2012

    Oh, I think you can start the trial right away! I think Herceptin is allowed on the AE37 trial. It's just that they want you to be within six months of finishing Herceptin before your first innoculation. Double check that but I think that's right. 

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  • TectonicShift
    TectonicShift Member Posts: 752
    edited May 2014

    Here is the latest data from the AE37 vaccine trial:   

    http://www.asco.org/ASCOv2/Meetings/Abstracts?&vmview=abst_detail_view&confID=125&abstractID=102964

    It's looking good -- TNBC patients take note! 

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  • kathleen1966
    kathleen1966 Member Posts: 793
    edited September 2012

    I  think I am too far out to be part of a vaccine trial.  I was disappointed by this.....

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  • TectonicShift
    TectonicShift Member Posts: 752
    edited May 2014

    Oh, Kathleen, I'm sorry. I know what you mean. I was too late for a trial that I wanted to get on too and it is disappointing. 

    However, if/when this vaccine gets approved, you will get the vaccine then. (I'm starting the trial next week, but I'm fully aware I might get the placebo.) And both the E75 and the AE37 vaccines are being moved along as quickly as possible. They are talking about stopping the AE37 phase 2 trial early so that they can ramp up a bigger phase 3 trial, which is required before approval from the FDA. And the E75 vaccine (aka NeuVax) is already in phase 3 trial.

    Also there is more good news about hormone-negative BC today. MDA is launching a massive $3 billion "moonshot" effort against eight cancers, one of which is TNBC. I see you're HER2+, but I say anything that helps the TNBC patients also helps the HER2+ patients and the ER+ patients (like me).

    http://www.huffingtonpost.com/2012/09/21/md-anderson-cancer-center-cures-deaths-_n_1903597.html 

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  • RosesToeses
    RosesToeses Member Posts: 721
    edited November 2012

    Just wanted to correct that the Neuvax trial does enroll patients with more than 3 positive nodes, so don't let that stop you if you're interested!

    Don't know yet if I'll meet the HLA criteria, but with my 7 positive nodes I have the concent paperwork in hand (wish me luck!).

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