ER+ 90% PR+ 5% HER2-1+

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lanagraves
lanagraves Member Posts: 596
edited June 2014 in Stage III Breast Cancer

I know that my HER2 1+ is actually considered negative. However, is my PR+ 5% also considered negative. My doctors have never told me this, but I read it somewhere. Does anyone know?

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  • lago
    lago Member Posts: 17,186
    edited September 2012

    My PR is 5%. My BS considers it negative my onc considers it positive. I am of the believe that you can't be a little bit pregnant. if you have a score then you are positive but not highly.

    you might be interested in this: linky   

    (Hope you don't mind me posting. I'm only 1 node away from being a stage IIIA. I'm a IIB)

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  • lanagraves
    lanagraves Member Posts: 596
    edited September 2012

    Thanks Iago. I don't mind at all. I really want to understand about the pathology of my cancer as well as possible. I think it makes (or should make) a real difference in our treatment plans. And I think, many times, the doctors do not use all of the available information to make decisions about individualized treatment.

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  • lanagraves
    lanagraves Member Posts: 596
    edited September 2012

    For example, there is new research out there suggesting that Herceptin is useful even for low HER2 positivity. Yet my MO refuses to give it to me. He also refuses to give me Zometa because I don't already have bone mets.

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  • lago
    lago Member Posts: 17,186
    edited September 2012

    My onc was going to give me Zometa then a report came out that said it doesn't help mets. Then the following year another report said it did. My onc currently is not on board with the Zometa for prevention until more studies are done even though initially she was.You might also check out the SE for Zometa. You might not be so inclined to take it.

    New research is just that. One or 2 studies don't make it so. There are also recent studies showing that the heart toxicity with Herceptin might be higher than they think years out. There women that are HER2+ that can't even finish the course of Herceptin because of heart damage. All drugs have SE. 

    Some of the studies are also poorly done or not on large populations. I think it's great that you bring these studies to your onc. Your onc should explain why he is not on board with yet.

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