ki67 and hormones

Could you ask your doctor your specific reduction in recurrence rate and increase in life expectancy by taking Tamoxifen? Perhaps that could help your decision?

Purple, it is certainly not a laughing matter, but you gave me a chuckle with the way you said that - that cancer can´t recur if the tamox gives you an embolism first. Some of these choices really are ridiculously hard.

Purple32: look up Rutin and blood clots. It is cheap and quite effective as scientific research shows.

http://www.inspire.com/TPALOMARES/journal/strontium-verses-biophosphanates/

I have a thread on Inspire if your interested in reading, you don't have to give up on Arimidex! I didn't want to take Arimidex either as it would lead to more degenerative Osteoarthritis and bone loss, but what follows is a bisphosphonate and that is what scared me which I will NOT take!!! I looked at alternatives and Strontium is prescribed in over 60 European countries but not ours!!! go figure! Anyways, it is available in the health food store. Best regards, TP

I'm not sure about AI's or Bisphosphonates. I'm fresh out the gate with diagnosis in Aug 2011, did all the adjunct stuff, now Total Hysterectomy and I'm suppose to be back on my Arimidex but it gives me terrible SE's, he wants to move on but I'm stalling-I had reaction to Tamoxifen which led to the Hysterectomy and Arimidex say's on pkg if your sensitive to T then A not going to work either. I'm a poor metabolizer and I feel if the little left Estrone (E1) in my adipose tissue can be addressed then I can slim down a lot-from what I understand estrogen lives in fat tissue, there's is nothing I can do about the estrone that the adrenals make but without any estrogen the body will just convert testosterone (Estrodiol) so your never going to be without any estrogen in your body. Aromatase, an enzyme in the body, turns the androgen testosterone into the estrogen estradiol. Estrogen converting cells in the adrenal glands, ovaries, placenta, testicles, adipose tissues, testicles, and brain contain this enzyme-too little androgen can cause several health problems-Arimidex cause's many SE's. I am in experimental mode right now. I am doing lab work on the estrogen panel giving me a baseline with no Arimidex then in 3 months, I will take the Arimidex-3 months from then, I will compare. If there is no huge drop in the estrogen panels then I do not see why I would need to take Arimidex, remember, I am a poor metabolizer of drugs and what doesn't work for me may work for you. This is just how I choose to gauge it.
Also, if your postmenopausal, your more than likely to be prescribed the Arimidex or some other AI-this is a paragraph from the prescribing sheet of Arimidex; 12.2 Pharmacodynamics it states: Effect on Estrodiol: Because aromoitization of adrenal androgens is not a significant source of Estrodiol in pre-menopausal women, Arimidex would not be expected to lower Estrodiol levels in pre-menopausal women"; so chemically, they are two different drugs-Tamoxifen is blocking the predominant source of Estrogen from the Ovary's while the Arimidex is inhibiting manufacturer through the adrenal glands and other areas of the body. Also noted in pkg info is that Arimidex blocks only 70% so it is certain that at least 30% of estrogen will remain in the body so if your doing panels with your ND, you will still have trace amounts show up.