ki67 and hormones

purple32

Hi all. As some of you may recall. I skipped rads due to bad lungs. I said no to arimidex because of osteo issues. My tammi rx is calling my name at the drug store but I hate the thought of it! I am 54 and 13 yrs out from menopause. You can see my stats and I a just found out my ki67 is under 5%. Would this low # impact your decusion on hormones. Or? ???? Please me as I have limited pc acesss for the week. Many Thx! !

bevin

Could you ask your doctor your specific reduction in recurrence rate and increase in life expectancy by taking Tamoxifen? Perhaps that could help your decision?

purple32

Hi Bevin

I am sure my dr. could give me some useful numbers. The problem is they do not weigh it against my increased risk of blood clots due to poor circulation. They minimize the more serious SEs like blod clots and stroke as though cancer trumps anything. Well, if it recurs - it does !  If you have  a pulmonary emobolism , it doesn't !

It's all a crap shoot -  and some people's odd are better/ worse than others when you factor in pre existing or underlying health conditions. The BC drs. tend not to do that. I dont fault them for it ...their primary concern is BC , as it should be.  Mine goes deeper than that. They dont seem to want to go there .

Momine

Purple, it is certainly not a laughing matter, but you gave me a chuckle with the way you said that - that cancer can´t recur if the tamox gives you an embolism first. Some of these choices really are ridiculously hard.

SpecialK

purple - could you possibly have an estrogen level test?  Maybe this would help you come to a decision.

bluepearl

Purple32: look up Rutin and blood clots. It is cheap and quite effective as scientific research shows.

purple32

Momine

I'm glad I gave you a chuckle.    Soemtimes our choices really are ludicrous! I soooo wish I could take the arimidex, but after 3 broken bones, it's not happening unless they hogtie me and force it down my throat.

Specialk  I asked my endo dr. ( my most cooperative dr.) to test my hormones and she said it wouldnt matter how they tested out ...that I would not see any difference after taking tammi in order to judge if the tammi is working since ' that is now how it works'.  Nobody will test me !  I went thru meno at 41...13 yrs ago.

bluepearl .  I did look it up.  Thank you. I think if I'm going to pop another pill- a natural, I might just go ahead with Activin GSE as a sub for arimidex.  still contemplating.

Many thanks for taking the time to reply!

vacationbound

http://www.inspire.com/TPALOMARES/journal/strontium-verses-biophosphanates/

I have a thread on Inspire if your interested in reading, you don't have to give up on Arimidex! I didn't want to take Arimidex either as it would lead to more degenerative Osteoarthritis and bone loss, but what follows is a bisphosphonate and that is what scared me which I will NOT take!!! I looked at alternatives and Strontium is prescribed in over 60 European countries but not ours!!! go figure! Anyways, it is available in the health food store. Best regards, TP

vacationbound

And yes, you can get your hormones tested-LEF.Org or zrtlab.com, testmyhormones.com, or testcountry.com, the saliva tests are very accurate, no need to draw blood. You have to call-going around your PCP may be necessary-these services offer their own Doc's for a fee as a script is req'd and only a doctor can receive info. Keep digging, you will find the answer.

vacationbound

I'm not sure about AI's or Bisphosphonates. I'm fresh out the gate with diagnosis in Aug 2011, did all the adjunct stuff, now Total Hysterectomy and I'm suppose to be back on my Arimidex but it gives me terrible SE's, he wants to move on but I'm stalling-I had reaction to Tamoxifen which led to the Hysterectomy and Arimidex say's on pkg if your sensitive to T then A not going to work either. I'm a poor metabolizer and I feel if the little left Estrone (E1) in my adipose tissue can be addressed then I can slim down a lot-from what I understand estrogen lives in fat tissue, there's is nothing I can do about the estrone that the adrenals make but without any estrogen the body will just convert testosterone (Estrodiol) so your never going to be without any estrogen in your body. Aromatase, an enzyme in the body, turns the androgen testosterone into the estrogen estradiol. Estrogen converting cells in the adrenal glands, ovaries, placenta, testicles, adipose tissues, testicles, and brain contain this enzyme-too little androgen can cause several health problems-Arimidex cause's many SE's. I am in experimental mode right now. I am doing lab work on the estrogen panel giving me a baseline with no Arimidex then in 3 months, I will take the Arimidex-3 months from then, I will compare. If there is no huge drop in the estrogen panels then I do not see why I would need to take Arimidex, remember, I am a poor metabolizer of drugs and what doesn't work for me may work for you. This is just how I choose to gauge it.
Also, if your postmenopausal, your more than likely to be prescribed the Arimidex or some other AI-this is a paragraph from the prescribing sheet of Arimidex; 12.2 Pharmacodynamics it states: Effect on Estrodiol: Because aromoitization of adrenal androgens is not a significant source of Estrodiol in pre-menopausal women, Arimidex would not be expected to lower Estrodiol levels in pre-menopausal women"; so chemically, they are two different drugs-Tamoxifen is blocking the predominant source of Estrogen from the Ovary's while the Arimidex is inhibiting manufacturer through the adrenal glands and other areas of the body. Also noted in pkg info is that Arimidex blocks only 70% so it is certain that at least 30% of estrogen will remain in the body so if your doing panels with your ND, you will still have trace amounts show up.