Upcoming onc visit-- drug vacation???

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momand2kids
momand2kids Member Posts: 1,508
edited June 2014 in Stage I Breast Cancer

I have been on femara and lupron since May 2009.  I am hovering close to the national average age of menopause (51) and have been thinking about getting off the lupron so we can see where I am in terms of menopause.  As I review my notes from my November onc meeting, I see that she says that we may be able to do this for the summer--- and possibly go off femara for the summer as well.... sort of a "drug vacation".

Has anyone done this?  I think I have to go off the lupron in order to figure out where my body is,and if it is not in menopause, I will have to go back on it in order for the femara to be effective.  While I love the idea of a vacation from all of the drugs, I am also a little leery..... I know I must have asked for it in the fall in a fit of frustration over some of the side effects (which, by comparison, are very mild) but I have cognitive fuzziness, vaginal dryness and some joint discomfort---all of which are manageable but aggravating..... 

Just wondering if anyone else took a break from the drugs.....

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  • NatsFan
    NatsFan Member Posts: 3,745
    edited May 2012

    I've been on Femara for almost 4 years.  In that time I've negotiated 3 one month "vacations" from Femara with my onc.  I negotiated the vacations when the s/e became so severe I was ready to go off the drug entirely.  I guess my onc figured it'd be better for me to take a vacation now and then if the overall end result was to keep me on the drug long term.

    After a week or so off the drug, most of the s/e began to resolve.  By the end of the month, just about all of them were gone.  I was able to get up from a chair and walk normally, not stagger with stiff joints like a 90 year old.  Weight began dropping off without any change in diet or exercise.  The short-term memory improved.  I was able to sleep the night through without night sweats or painful joints/muscles waking me up.  The nice thing is that once the vacation was over and I resumed letrozole, the s/e took several weeks to get back to the intensity they were before.

    Yes, it's a calculated risk.  I'm Stage IIB.  My decision might have been different if I were a later stage.  But I'm taking other risk reduction measures such as losing weight and exercising vigorously for at least 30 minutes a day.  After long discussions with my onc, I was willing to accept the risk of going off for a month to get some relief and give me courage to keep going for my full 5 years.

  • SpecialK
    SpecialK Member Posts: 16,486
    edited May 2012

    The only break I have taken from Femara was about 3 weeks at the request of my PS because I still have a port, and was having exchange surgery.  He was concerned about the clot risk.  I was pleasantly surprised that the joint aching dissipated, and I did seem to have more energy.  Hard to tell about the sleep pattern because I was newly post-surg, and my hot flashes pre-dated Femara.  I also experienced the several week delay in the onset of SEs when I resumed Femara.

  • coraleliz
    coraleliz Member Posts: 1,523
    edited May 2012

    I believe I read on a thread here that 3 month vacations are being studied as a way to improve pt compliance with these drugs. 9 months on, 3 months off. If you turn out not to be menopausal, will you be stopping next year for 3 months to test again? Can you wait until next year because you will be more likely to be menopausal then(if you have concerns about stopping)?  

  • momand2kids
    momand2kids Member Posts: 1,508
    edited May 2012


    Thanks for the replies...

    Coraleiz, if I go off and am not in menopause, then I have to go back on asap.... so, if I go off for a month and get my period, then we know I am not there yet..... 

    I ended chemo in Feb 2009-started the drugs in June 2009--did not have a period in between-- and now I think I really may be menopausal---- 

    I guess I am worried about two things-- the first, what kind of effects will my body have once I go off?  I don't have hot flashes now and the joint pain has been eradicated in general by exercise..... as long as it won't be worse, I am willing to try it.

    My other concern, which is far more serious, is , if I go off for a short period of time and somehow have a recurrence?  I am stage 2--- but that is the risk part that I am not sure about.....

    sigh, none of these things are easy....

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