AB blood type and breast cancer

I'm AB+ and this is new news to me.  Could you kindly reference your information so I can look at it.  Thank you.

ABO blood group and breast cancer incidence and survival.

Source

Channing Laboratory, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA, USA. nhmag@channing.harvard.edu

Abstract

ABO blood type has been associated with risk and survival for several malignancies; however, data for an association with breast cancer are inconsistent. Our study population consisted of Nurses' Health Study participants with self-reported serologic blood type and/or ABO genotype. Using Cox proportional hazards regression, we examined the association between serologic blood type and incident breast cancer among 67,697 women, including 3,107 cases. In addition, we examined the association with ABO genotype in a nested case-control study of 1,138 invasive breast cancer cases and 1,090 matched controls. Finally, we evaluated the association between serologic blood type and survival among 2,036 participants with breast cancer. No clear association was seen between serologic blood type or ABO genotype and risk of total breast cancer, invasive breast cancer or breast cancer subtypes. Compared to women with blood type O, the age-adjusted incidence rate ratios for serologic blood type and total breast cancer were 1.06 (95% CI, 0.98-1.15) for type A, 1.06 (95% CI, 0.93-1.22) for AB and 1.08 (95% CI, 0.96-1.20) for B. In genetic analyses, odds ratios for invasive breast cancer were 1.05 (95% CI, 0.87-1.27) for A/O, 1.21 (95% CI, 0.86-1.69) for A/A, 0.84 (95% CI, 0.56-1.26) for A/B, 0.84 (95% CI, 0.63-1.13) for B/O and 1.17 (95% CI, 0.35-3.86) for B/B, compared to O/O. No significant association was noted between blood type and overall or breast cancer-specific mortality. Our results suggest no association between ABO blood group and breast cancer risk or survival.

Copyright © 2011 UICC.

As far as I can gather from a quick google, this is controversial info and based on a few small and/or flawed studies.



Someone already posted one study which concluded that ABO blood group is not relevant in breast cancer.

Very interesting theories.  Mother is B- and had BC, whereas I'm O+ and have BC.

Thank you for sharing the information.  The information that I just posted is the most current available information regarding the topic and IMHO, I think researchers, though interested in determining if a link exists, have not been able to find one. 

Since the relevance of ABH blood group antigens as tumor markers and parasitic/bacterial/viral receptors and their association with immunologically important proteins is now well established, the prime biologic role for ABH blood group antigens may well be independent and unrelated to the erythrocyte.

http://www.ncbi.nlm.nih.gov/pubmed/11578255?dopt=Abstract

ABH and related histo-blood group antigens in normal & malignant human endometrium in relation to genetic and hormonal factors 

http://www.ncbi.nlm.nih.gov/pubmed/9254838 

Costantini M, Fassio T, Canobbio L, et al. Role of blood groups as prognostic factors in primary breast cancer. Oncology 1990;47(4):308-12

Skolnick MH, Thompson EA, Bishop DT, Cannon LA. Possible linkage of a breast cancer-susceptibility locus to the ABO locus: sensitivity of LOD scores to a single new recombinant observation. Genet Epidemiol 1984;1(4):363-73

Mourali N, Muenz LR, Tabbane F, et al. Epidemiologic features of rapidly progressing breast cancer in Tunisia. Cancer 1980;46:2741-6

Rosen PP, Schwartz MK, Menedez-Botet CJ. Blood groups and response to therapy for mammary cancer. Am J Clin Pathol 1977;67:504-5 [Letter]

Anderson DE, Haas C. Blood type A and familial breast cancer. Cancer 1984 Nov 14(9):1845-1849

Tryggvadottir L, Tulinius H, Robertson JM. Familial and sporadic breast cancer cases in Iceland: a comparison related to ABO blood groups and risk of bilateral breast cancer. Int J Cancer 1988 Oct 15;42(4):499-501

Horn PL, Thompson WD. Risk of contralateral breast cancer. Associations with histological, clinical, and therapeutic factors. Cancer 1988;62:412-24.

Holdsworth PJ, Thorogood J, Benson EA, Clayden AD. Blood group as a prognostic indicator in breast cancer. Br Med J (Clin Res Ed) 1985 Mar 2;290(6469):671-3

"My observation has been that blood type A women have a generalized tendency to worse outcomes and a more rapid progression with this cancer. Research indicates that blood type A women are over-represented among breast cancer patients, and that this trend occurs even among women thought to be at low risk for cancer. One of the most significant risk factors for a rapidly progressing breast cancer is also blood type A, and blood type A women have been observed to have poorer outcomes once they are diagnosed with breast cancer. In complete opposition to these blood type A tendencies, we find blood typee O. Blood type O infers a slight degree of resistance against breast cancer, and even among patients, blood type 0 showed a significantly lower risk of death. Type AB's fall nearer to A's, having a slight increase in susceptibility and a more dramatic trend towards recurrence and shorter survival times. Blood type B generally acts a bit more like blood type O, imparting a degree of reduced susceptibility or reduced risk. This is particularly evident among women who do not have a family history of breast cancer. However, there are two areas to consider if you are a blood type B woman. If you have had a family member with breast cancer, the protection normally associated with being a B women goes out the window, and you need to be more aware of the possibility of breast cancer. Also, if you are a B women and currently have or have had breast cancer, statistically speaking, your odds of a recurrence of breast cancer tend to be higher"

http://www.dadamo.com/science_ABO_cancer.htm  

I figure there's NO HARM adopting Dr. D'adamo's recommendations, anything that helps ! 

Maud...The information that you reference is decades old.  The information that I just posted is the most recent research.

And, I know I'm going to start a controversy here when I say, I most humbly disagree with your statement Maud that there is "NO HARM adopting Dr. Adamo's recommendations."  From the examples I gave, CLEARLY much thought and attention and MONEY was directed toward researching whether or not a connection exits.  It sure would be exciting and HELPFUL if a connection was found and then MORE thought, attention AND MONEY could be directed towards finding a treatment and cure.  I appreciate that these researchers took their VALUABLE time to research this important area.  But once NO connection is found, I think it is HARMFUL to continue DEVOTING THOUGHT, ATTENTION AND MONEY to that research.  You see, that's what's so interesting about research.  Sometimes research DOESN'T PAN OUT how we would like it to.  And that's okay!  But continuing to BELIEVE that a treatment based on a theory that has been proven to be INCORRECT ultimately DOES NOT HELP  patients.  And for patients who are frightened and grasping at straws, promoting treatments that are based on theories that have been PROVEN to be INCORRECT is in my humble opinion HARMFUL to ALL OF US.

Type B.

Obviously some of you are ignoring what constitute Dr. D'Adamo's recommendations.  Eat according to your blood type, NO MORE, NO LESS.  How much more dangerous can that be ??? LOL  

Kayb: "that blood type supposedly helps unless you have family history of BC" MEANS that, in cases of BC with NO family history, his theory is supported by research which you choose to ignore

VR - I sure wish they had "revised to current year" textbooks in medical school, don't you ?

The study you refer to was received December 21, 2009, not all that current is it ?

and since none of your links work, I'm not gonna waste time.  Its lead author IS FROM CCofA

If your post wasn't so misleading, it would be almost comical, really 

Mainstream physicians rarely look at this but there has been a movement in the naturopathic medical community to look at the research on this topic and apply it to their patients.

Most of the research is being done by medical anthropologists and medical doctorates in institutions, and the publications are printed in the more obscure journals such as "The European Journal of Dentistry", and the "International Journal of Epidemiology".

Clinicians typically do not read such specific journals, these are most frequently read by researchers in their specific fields.

Among medical anthropologists, it has been noted that people with blood type A have higher rates of esophageal, pancreatic and stomach cancers, while those with blood type O have higher rates of peptic and duodenal ulcers.

In a recent study, researchers looked several groups of women and found a small preponderance of blood type A in the breast cancer groups.

There has been very good research showing that patients with blood type O who have breast cancer do better than other blood type patients, significantly better. The blood types that fair the worst outcomes tend to be AB.

The list in longterm survival rates from best to worst is O>A>B>AB. Note, this is statistics and individual cases always brake the mold. So even though women with blood type A have a slightly greater chance or getting breast cancer, they tend to fair better than those with B or AB, but not as well as those with O.

ABO blood group and incidence of epithelial ovarian cancer
Margaret A. Gates1,2,†,*, Brian M. Wolpin3,4, Daniel W. Cramer2,5, Susan E. Hankinson1,2, Shelley S. Tworoger1,2
Article first published online: 22 MAR 2010
DOI: 10.1002/ijc.25339
Copyright © 2010 UICC
Issue
International Journal of Cancer
Volume 128, Issue 2, pages 482-486, 15 January 2011 

"In this large, prospective cohort of women, blood groups AB and B were associated with a borderline significant increased incidence of ovarian cancer. The magnitude of the association was similar for blood group AB and blood group B suggesting that the B antigen may influence ovarian carcinogenesis. In analyses of presence versus absence of a B allele, we observed a statistically significant increase in incidence of all epithelial cancers and the serous invasive subtype. Although the sample size was limited, the stronger positive associations observed among overweight women should be evaluated in future studies.

Several studies have reported a positive association between blood group A and ovarian cancer risk, but no association with blood group B.1-4, 11, 12 In 4 studies, the relative frequency of blood group A versus O was higher in ovarian cancer cases than in a large population sample, with estimates of the relative risk ranging from 1.17 to 1.28.1-4 "

Now, you do your own digging 

geeze, you missed that part...

"we observed a statistically significant increase in incidence of all epithelial cancers and the serous invasive subtype" 

FYI : Cancers of the epithelial cells are called carcinomas 

It's up to you to post links that work, not me.  I have no interest in the study you cited, too many studies contradict yours 

All I can suggest to you kayb is the following:

http://www.xtranormal.com/watch/7618367/im- 

"There are THREE main types of ovarian tumors (click
on type diagnosed):

Epithelial ovarian tumors are derived from the cells on the surface of the ovary. This is the most common form of ovarian cancer and occurs primarily in adults.Germ cell ovarian tumors are derived from the egg producing cells within the body of the ovary. This occurs primarily in children and teens and is rare by comparison to epithelial ovarian tumors. Sex cord stromal ovarian tumors are also rare in comparison to epithelial tumors and this class of tumors often produces steroid hormones."

Maud,

I'm sure you have me on ignore as well, so this message may as well fall on deaf ears.  But I have to ask the question, because this determination to be "right" shines through on every one of your posts.  Why is it so important for you to dig your heels in and claim to always be right?  Even if sometimes you cut your nose off despite your face?  I'm not sure if that's the right analogy, but I'm sure others on here are wondering the same.  

It seems as if your determination to have to be "right" totally ignores the facts some of the time.  Sometime you're right, sometime you're not, and that's okay!  None of us is correct all the time. But also just choosing to ignore any information or opinions that don't happen to concur with yours seems to constrain your world, you know?  

This post definitely is not meant to be harsh, but I had to ask this question!