If you have been wondering about the Alkaline Diet
This is probably not the right forum, but since the Alternative Medicine forum urges posters to be nice and it is designed as a "safe haven" for discussion of alternatives, I wasn't sure where to post this. I invite the moderators to remove this post or direct it to the appropriate area. Please know that I do have a bachelor of SCIENCE degree in biology and am employed as a CHEMIST. I don't claim to be an authority on the subject of body pH or a doctor, but a basic course in human anatomy and physiology is enough to reveal the Alkaline Diet concept as SCAM material.
Please people, I am so tired of reading about people "raising their body pH" through a diet and drinking baking soda, alkaline water, etc. Most recently, it was discussed tonight in a post NOT on the alternative thread, but in a threat about consuming alcohol. For some reason, it really set me off. THESE ARE SCAMS designed to sell a product and should NOT be considered as any form of cancer treatment, no matter how convincing the "article" or sales person is. I am not saying the member/poster was trying to sell or push this concept, but it comes up often enough that it should be addressed.
The following is a 5 minute primer on the acid-base buffer system of the human body. Stop reading now if you want to.
The normal, healthy human body is an incredible machine which self-regulates hundreds of chemical reactions simultaneously to ensure HOMEOSTASIS. We have several redundant systems which buffer (remove excess hydrogen ions (H+) or release bicarbonate (HCO3-) or phosphate buffer ions when acid is generated by things like exercise, consuming acid beverages like orange juice (pH 3.5) or coffee pH 4-5, deadly vinegar from pickles (OMG pH 2.3), or as the result of metabolic disorders like diabetes. That soreness after exercising is a result of a buildup of lactic acid when you run out of easy glucose for fuel and start utililizing fat as fuel.
Basic systems which regulate blood pH:
Respiratory system - excess acid dissolved in the bloodstream as carbonic acid is EXHALED as CO2 (carbon dioxide). If too much acid builds up (such as during exercise), our hearts pump faster and we breathe faster to increase the intake of oxygen and the release of carbon dioxide (thus raising blood pH).
Urinary system - the kidneys excrete excess H+ ions in the body, as well as regulating the water content by retaining or releasing sodium ions (salt). They also excete excess protein and water as needed.
In general, all of the cells in your body are continually exchanging ions back and forth across the cell membranes to keep everything in balance. Its a beautifully designed system. No matter how much alkaline water and sodium bicarbonate you drink, your body will work to reverse what you are trying to do to it to maintain HOMEOSTASIS. This is not to say that the systems always work perfectly. There are lots of diseases that affect these systems and adversely impact their functioning.
A blood pH below 6.8 (metabolic acidosis) or above 7.8 (alkalosis) can be FATAL. Just ask any diabetic about the risk of ketoacidosis. You can keep trying to raise your blood pH to alkaline levels, but your body will be fighting you all the way trying to maintain the proper NEUTRAL pH.
And how are you determining your pH? By urine strips? Expensive, huh? The pH of urine may be acid or basic, as determined by your kidneys in order to maintain homeostasis. Check your past labs and I'm pretty sure you will never see your blood pH above or below the normal range of 7.3-7.4 unless you are sick in the hospital. Save your money for healthy food and a gym membership.
Heartburn and acid reflux are not a symptom of acid body pH. It is the result of your esophageal sphincter not working properly and allowing NORMAL stomach acid to enter your esophagus. The body makes acid to help you digest your food. Without acid, the food would not be broken down into its basic building blocks and would pass through your body undigested.
I hope this post has been helpful. If you read this far, I hope I was clear enough without going into the details of the chemical reactions (not like I could anyway without looking them up). Please, just don't be duped into these snake oil scams that take advantage of desperate people with misinformation that SOUNDS scientific. It isn't.
Hugs, Sisters and Brothers
Comments
-
I just want to thank you for this! I have been offered every friggin thing imaginable and this Diet is one of them....needless to say I looked at it ... and filed it.
You're post is very helpful. I love that you are in the field and you have listed information that anyone can verify with reliable sources. These "diets" also get very expensive and/or time consuming.
Nice job!
-
Thank you for this. I totally agree. I am on an anti-cancer diet, but I have never considered measuring my pH as a way to gauge my success, because I know that your body will pretty much do whatever it takes to keep everything at a neutral level.
-
Thank you!
-
Thank you for posting this!
-
Thanks for the information!
-
Thank you. I was recently forced to buy an alkaline sort of glass container that will change the ph of the water to alkaline. I didnt used it yet because I know how our body works.
-
Thanks y'all. I would have been happy for this post to die a slow death in the forum called "never read posts". I just needed to get that off my chest. I am glad to know it was helpful if even a little bit.
@dlcp - forced?? Got the hard sell? Sometimes it is easier just to buy something than to go on arguing sense with some people!
-
I have a science background as well, an Honours Degree in Animal Biology. I tended towards believing what you wrote above, based on my understanding of the buffer system that regulates ph. Then I read this. Without commenting on the "Alkaline diet" concept, I do however have a more open mind about the concept of ph and cancer.
http://www.ncbi.nlm.nih.gov/pubmed/21155627
Manipulating tumor acidification as a cancer treatment strategy.
Source
Oasis of Hope Hospital and Whitaker Wellness Institute. markfmcarty@gmail.com
Abstract
Manipulation of the extracellular and/or intracellular pH of tumors may have considerable potential in cancer therapy. The extracellular space of most tumors is mildly acidic, owing to exuberant production of lactic acid. Aerobic glycolysis - attributable largely to chronic activation of hypoxia-inducible factor-1 (HIF-1) - as well as tumor hypoxia, are chiefly responsible for this phenomenon. Tumor acidity tends to correlate with cancer aggressiveness; in part, this reflects the ability of HIF-1 to promote invasiveness and angiogenesis. But there is growing evidence that extracellular acidity per se boosts the invasiveness and metastatic capacity of cancer cells; moreover, this acidity renders cancer cells relatively resistant to the high proportion of chemotherapeutic drugs that are mildly basic, and may impede immune rejection of tumors. Thus, practical strategies for raising the extracellular pH of tumors may have therapeutic utility. In rodents, oral administration of sodium bicarbonate can raise the extracellular pH of tumors, an effect associated with inhibition of metastasis and improved responsiveness to certain cytotoxic agents; clinical application of this strategy appears feasible. As an alternative approach, drugs that inhibit proton pumps in cancer cells may alleviate extracellular tumor acidity while lowering the intracellular pH of cancer cells; reduction of intracellular pH slows proliferation and promotes apoptosis in various cancer cell lines. Well-tolerated doses of the proton pump inhibitor esomeprazole have markedly impeded tumor growth and prolonged survival in nude mice implanted with a human melanoma. Finally, it may prove feasible to exploit the aerobic glycolysis of cancers in hyperacidification therapies; intense intracellular acidification of cancer cells achieved by induced hyperglycemia, concurrent administration of proton pump inhibitor drugs, and possibly dinitrophenol, may have the potential to kill cancer cells directly, or to potentiate their responsiveness to adjunctive measures. A similar strategy, but without proton pump inhibition, could be employed to maximize extracellular tumor acidity, enabling tumor-selective release of cytotoxic drugs encased in pH-sensitive nanoparticles.
Some more recent work on the proton pump inhibition idea:
-
Thank you so much! I've been reading about this on the boards and didn't know what to think except it souded fishy. No I know it's bunk.
-
Well, here's my take. What you eat (or don't eat) can make your body's environment more or less friendly to cancer cell growth. Foods that are considered "acidic," such as meat, dairy, and sugar, are often cancer-promoters - they induce inflammation, promote the growth of IGF-1 and N-kappa B. Foods that are considered alkaline, such as vegetables, fruits, omega 3 oils, often reduce inflammation, inhibit IGF-1 and N-kappa B and promote anti-angiogenisis. So the whole alkaline diet idea has some merit in that it can help you create an environment that is less friendly to cancer. But saying that you can test your pH is silly, since your body will attempt to keep it neutral regardless of what you are eating.
Now. I just want to clarify that I don't believe that diet alone can cure cancer or that any one thing you eat can cause it to grow. If a healthy diet alone prevented cancer, I would not have it, but some of my super-unhealthy friends would. However, after all I have read, I think there is a lot of value in an "anti-cancer" diet and I am happy to stay on it. I must assume that there are a few cancer cells bouncing around in my body after treatment, so my goal is to make life hard for them so that they experience apoptosis or, at the very least, never find a place to call home.
-
I know nothing about biochemistry, so maybe someone knowledgeable could comment on these links.
Grant to Fuel Baking Soda Cancer Therapy Research
Bicarbonate Increases Tumor pH and Inhibits Spontaneous Metastases
-
thank you for the information, very helpful. sweetbean, very well said....
-
Hi Timothy, thanks for the abstract. I did go to the journal article on PubMed and found some other references that are similar. From the abstract you provided though, you have to read carefully:
Manipulation of the extracellular and/or intracellular pH of tumors may have considerable potential in cancer therapy. The extracellular space of most tumors is mildly acidic, owing to exuberant production of lactic acid. Aerobic glycolysis - attributable largely to chronic activation of hypoxia-inducible factor-1 (HIF-1) - as well as tumor hypoxia, are chiefly responsible for this phenomenon. Tumor acidity tends to correlate with cancer aggressiveness; in part, this reflects the ability of HIF-1 to promote invasiveness and angiogenesis... practical strategies for raising the extracellular pH of tumors may have therapeutic utility. In rodents, oral administration of sodium bicarbonate can raise the extracellular pH of tumors, an effect associated with inhibition of metastasis and improved responsiveness to certain cytotoxic agents; clinical application of this strategy appears feasible. As an alternative approach, drugs that inhibit proton pumps in cancer cells may alleviate extracellular tumor acidity while lowering the intracellular pH of cancer cells;
Do you interpret that as tumors "create" their own acidic environment because they metabolize glucose so quickly that they go into hypoxic metabolism of glucose which results in the production of lactic acid. The tumor is not a result of an extracellular acidic environment, it makes it. Moreover, the rest of the abstract says that if they can turn on the inhibitor of the proton pumps (creating H+) which create the acid, then it would help slow down the tumor's growth. Tumors that are very good at tolerating the low pH are indeed more aggressive. There are lots of acid-adapted bacteria and fungi (we study this in the food industry), so it's not surprising that some tumors are making their own acidic environment.
I'm still reading one of the bicarbonate papers that JoyLW provided - it is really interesting.
The external pH of solid tumors is acidic as a consequence of increased metabolism of glucose and poor perfusion. Acid pH has been shown to stimulate tumor cell invasion and metastasis in vitro and in cells before tail vein injection in vivo. The present study investigates whether inhibition of this tumor acidity will reduce the incidence of in vivo metastases. Here, we show that oral NaHCO3 selectively increased the pH of tumors and reduced the formation of spontaneous metastases in mouse models of metastatic breast cancer. This treatment regimen was shown to significantly increase the extracellular pH, but not the intracellular pH, of tumors by 31P magnetic resonance spectroscopy and (increase) the export of acid from growing tumors ...The extracellular pH (pHe) of malignant solid tumors is acidic, in the range of 6.5 to 6.9, whereas the pHe of normal tissues is significantly more alkaline, 7.2 to 7.5 (1-3). Mathematical models of the tumor-host interface (4) and in vivo measurements have shown that solid tumors export acid into the surrounding parenchyma (5, 6). Previous in vitro studies have shown that tumor cell invasion can be stimulated by acidic conditions and that this may involve lysosomal proteases (7-9). These observations have led to the "acid-mediated invasion hypothesis," wherein tumor-derived acid facilitates tumor invasion by promoting normal cell death and extracellular matrix degradation of the parenchyma surrounding growing tumors. Furthermore, pretreatment of tumor cells with acid before injection leads to increased experimental metastases (10, 11), and these observations suggest that low pH up-regulates proinvasive and survival pathways. It has been argued that metastatic cancers are selected for their ability to export acid (12). Acid is a by-product of glucose metabolism, and notably, elevated consumption of fluorodeoxyglucose by more aggressive cancers has been observed with fluorodeoxyglucose positron emission tomography (13).
So far it is saying that the acid pH generated by a growing tumor kills off normal cells and breaks down the surrounding tissue for its own uses. It looks like they had some success with mouse models, so I will keep reading. Who knew they install windows in mice so they can see the tumors? I'll get back to you with how it ends.
That last part about glucose and PET scans I'm sure is the basis for the whole anti-sugar effort. Every cell in the body runs on glucose, not just tumors. All food we eat is eventually converted to glucosed. Tumor cells just use more because of their fast cell division rate. This is why they use a glucose tracer during PET scans. It does not mean that sugar is the culprit.
I agree with Sweetbean that something must have caused our cancers. I lean more toward the mutagens/toxin that damage DNA and DNA repair mechanisms. I've been exposed to so many chemicals, it's not funny. I think we are probably all exposed more than we believe.
Thanks for the discussions, this is fun.
-
Hi - I realize the basis for the thread is about the sales of products that possibly can raise pH. Cesium chloride. LIPH drops into water. Diatemateous earth. These definitely should not be presented as a cure for cancer. But to me, they can be helpers as needed.
Maybe they will not work to raise pH. The body does control its own, definitely, and all are individuals.
But the fact for me, my pH in both urrine and saliva, tested several times each day for several days at a time...... I was in the low range, around 4.5 when the cancer was active. Frankly, the test strips were very yellow. Right after the surgery, the pH was 7ish, very dark blues and greens. Then went low again and remains so, though not lemon yellow.
I am learning to use the Chinese medicine values for my foods, resulting in a more alkaline food plan which benefits me at this time.
But it is all about balance.
http://www.shen-nong.com/eng/lifestyles/food_property_food_tcm.html
Perhaps you will find this article interesting. It is easy to read, why I like this one best.
-
Shelly and Timothy ... I really enjoy this debate. Naturally it's a heavy one but ... WHOA ... ya all really know how to tackle a subject!
I believe chemical exposure is a huge issue and cancer cause ... possibly even generations before we were born.
Rock on.
-
-
Hey Fuzz!
-
How ya doin'?
-
Thanks for your post. This layman approach has made it much easier for me to understand.
-
It's a great thread. I really appreciate someone taking the time to explain something I've been scratching my head over for ages.
Since the NIH are donating a grant of $2 million to investigate this, it seems to be a viable theory. And this quote from the article "Drinking baking soda has been proven to reduce or eliminate the spread of breast cancer to the lungs, brain and bone, but too much of it can damage normal organs.", is that a misunderstanding on the part of the article's author?
Maybe the misunderstanding is that it's the tumour pH that's changed, not the blood pH, but then how could it damage normal organs?
-
Hi Joy, I read about half of the 2nd article you posted. Which one was that quote from? I'll try to sneak it in at work today. It looked to me from the photos of the lung tissue (2nd article) that they did have success in preventing mets to the lungs in mice - really clearly), without raising the blood pH, which would damage normal organs. They think had something to do with making circulating tumor cells less aggressive or unable to colonize other tissue. I need to read more but have to go to work now. This is very interesting!
-
Thanks, but don't get into trouble at work! No hurry.
It was my first link about the grant. So they are interpreting a study or quoting one of the researchers maybe.
-
Hi again and good morning!
It sounds like the acidification exists, or is being observed, in extracellular tissue very localized and in the area around the cancerous tumours. It also sounds like - and this makes sense owing to the natural blood buffer system - that the influence of adding alkaline substances, in this case, bicarbonate, influences that low ph environment created by the growing tumour.
I know they have done other research to substitute another alkaline substance, and it was equally effective in slowing the tumour metastasis. This was meant to demonstrate whether it was unique to sodium bicarbonate, or a consequence of the ph.
I'm not raising any of this as a treatment option. Just food for thought about a process of acidification that is being revealed as having potential. I've looked at the alternative medicine recommendations for sodium bicarbonate consumption, and it looks like one would be consuming considerable quantities of sodium as a consequence. That might not be healthy. Sodium bicarbonate has been consumed by athletes to increase the ability of the bicarbonate buffer system to buffer against lactic acid, and enhance performance in very specific events, such as sprinting. Some studies confirm the positive effect on performance, but others don't.
-
Ya know, I've been thinking ... Shelley and Timothy need to work together - for real!!! You both have an incredible knowledge (and maybe passion) for these topics!!
Just for an incredible amount of laughs .... you both should read OMG They Found a Cure for Stupid (if you haven't already). Start from page one ... if you don't shoot coffee/soda/tea/water all over your computer screen by page 10, I'll drink Baking Soda (LOL).
-
I'll say this much for the alkaline buzz: it has me eating a healthy diet at last. At the very least, eating relatively more alkaline foods would reduce the stress burden on the body of trying to maintain a normal ph in the presence of cancer cells producing lactic acid through their anaerobic respiration. Now, I'm not going to drink baking soda or buy any special product. I am eating mostly vegetables and fruits (as much organic as possible) and only a little meat or fish. I drink green tea now, because it is more alkaline. Black tea is more acid. I treat myself to a cappuccino (acid) once a week.
I'm still working on the exercise deal. It's been tough getting my act together. I went back to work too soon!
-
Trust me, Fuzzy, I would much rather be working in cancer research now than citrus! BORING! We just found out some of us are going to get "transitioned" to grant funding. That is not good news. Timothy, what area do you work in?
Dunesleeper, I'm slipping in a little experiment tomorrow at work because I'm not too sure about how it is decided what foods are acidic or alkaline. I have a pH meter and pH papers so I'm going to measure the pH of a few things. I drink green tea twice a day, too, because it has lots of antioxidants and i'm definitely eating a lot better than I was (including organic when possible).
You guys want me to let you know what I find? I'm curious about the meat (in a blender?) and the claims that citrus "turns alkaline" in the body. Citrus is full of citric acid (which is obviously acidic), we measure it every day as a parameter of juice quality (the balance between sweetness as Brix and acid is a key ratio). Maybe we need a nutritionist to explain this.
-
Keep posting the info! I'm trying to eat better and am really curious about whether the ph going in matters. I wonder what happens to my black tea when I drink it with milk.....
-
Unravelling any one of these ideas, like diet and ph is extremely complex. I wish I worked in the field. I should have continued on with my studies in Biology and gotten into research. Instead, I went to law school and now that's my vocation.
One of the considerations in quantifying acids and bases and ph is not only their molarity (a measure of quantity) but the strength of an acid or base (a measure of its tendency to dissociate into H+ or 0H- ). Someone mentioned aspirin in another thread. Aspirin is indeed an acid, but it is a relatively weak acid.
-
Oh yeeeeeees!!! POST POST POST!!!
Law you say, Timothy? Specialty? -
I do what you might call solicitor's work. The stuff that doesn't take you to court (although every once in a while I do go to court, if its something that interests me and I really believe in it). So, lots of paperwork. Real estate, corporate, wills and estates, that kind of stuff.
Categories
- All Categories
- 679 Advocacy and Fund-Raising
- 289 Advocacy
- 68 I've Donated to Breastcancer.org in honor of....
- Test
- 322 Walks, Runs and Fundraising Events for Breastcancer.org
- 5.6K Community Connections
- 282 Middle Age 40-60(ish) Years Old With Breast Cancer
- 53 Australians and New Zealanders Affected by Breast Cancer
- 208 Black Women or Men With Breast Cancer
- 684 Canadians Affected by Breast Cancer
- 1.5K Caring for Someone with Breast cancer
- 455 Caring for Someone with Stage IV or Mets
- 260 High Risk of Recurrence or Second Breast Cancer
- 22 International, Non-English Speakers With Breast Cancer
- 16 Latinas/Hispanics With Breast Cancer
- 189 LGBTQA+ With Breast Cancer
- 152 May Their Memory Live On
- 85 Member Matchup & Virtual Support Meetups
- 375 Members by Location
- 291 Older Than 60 Years Old With Breast Cancer
- 177 Singles With Breast Cancer
- 869 Young With Breast Cancer
- 50.4K Connecting With Others Who Have a Similar Diagnosis
- 204 Breast Cancer with Another Diagnosis or Comorbidity
- 4K DCIS (Ductal Carcinoma In Situ)
- 79 DCIS plus HER2-positive Microinvasion
- 529 Genetic Testing
- 2.2K HER2+ (Positive) Breast Cancer
- 1.5K IBC (Inflammatory Breast Cancer)
- 3.4K IDC (Invasive Ductal Carcinoma)
- 1.5K ILC (Invasive Lobular Carcinoma)
- 999 Just Diagnosed With a Recurrence or Metastasis
- 652 LCIS (Lobular Carcinoma In Situ)
- 193 Less Common Types of Breast Cancer
- 252 Male Breast Cancer
- 86 Mixed Type Breast Cancer
- 3.1K Not Diagnosed With a Recurrence or Metastases but Concerned
- 189 Palliative Therapy/Hospice Care
- 488 Second or Third Breast Cancer
- 1.2K Stage I Breast Cancer
- 313 Stage II Breast Cancer
- 3.8K Stage III Breast Cancer
- 2.5K Triple-Negative Breast Cancer
- 13.1K Day-to-Day Matters
- 132 All things COVID-19 or coronavirus
- 87 BCO Free-Cycle: Give or Trade Items Related to Breast Cancer
- 5.9K Clinical Trials, Research News, Podcasts, and Study Results
- 86 Coping with Holidays, Special Days and Anniversaries
- 828 Employment, Insurance, and Other Financial Issues
- 101 Family and Family Planning Matters
- Family Issues for Those Who Have Breast Cancer
- 26 Furry friends
- 1.8K Humor and Games
- 1.6K Mental Health: Because Cancer Doesn't Just Affect Your Breasts
- 706 Recipe Swap for Healthy Living
- 704 Recommend Your Resources
- 171 Sex & Relationship Matters
- 9 The Political Corner
- 874 Working on Your Fitness
- 4.5K Moving On & Finding Inspiration After Breast Cancer
- 394 Bonded by Breast Cancer
- 3.1K Life After Breast Cancer
- 806 Prayers and Spiritual Support
- 285 Who or What Inspires You?
- 28.7K Not Diagnosed But Concerned
- 1K Benign Breast Conditions
- 2.3K High Risk for Breast Cancer
- 18K Not Diagnosed But Worried
- 7.4K Waiting for Test Results
- 603 Site News and Announcements
- 560 Comments, Suggestions, Feature Requests
- 39 Mod Announcements, Breastcancer.org News, Blog Entries, Podcasts
- 4 Survey, Interview and Participant Requests: Need your Help!
- 61.9K Tests, Treatments & Side Effects
- 586 Alternative Medicine
- 255 Bone Health and Bone Loss
- 11.4K Breast Reconstruction
- 7.9K Chemotherapy - Before, During, and After
- 2.7K Complementary and Holistic Medicine and Treatment
- 775 Diagnosed and Waiting for Test Results
- 7.8K Hormonal Therapy - Before, During, and After
- 50 Immunotherapy - Before, During, and After
- 7.4K Just Diagnosed
- 1.4K Living Without Reconstruction After a Mastectomy
- 5.2K Lymphedema
- 3.6K Managing Side Effects of Breast Cancer and Its Treatment
- 591 Pain
- 3.9K Radiation Therapy - Before, During, and After
- 8.4K Surgery - Before, During, and After
- 109 Welcome to Breastcancer.org
- 98 Acknowledging and honoring our Community
- 11 Info & Resources for New Patients & Members From the Team