What antidepressant worked best for you?

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I know we're all different, but I need some help with this decision. In the past I had been on Zoloft with Wellbutrin (to offset the side effects of the Zoloft). I've tried several SSRI's over the years (fto also help with migraines) and they haven't been a great success.

I hate the thoughts of going back on something, there are so many side efects with the newer drugs, and with cancer, the last thing I want is to aggrevate the condition, .but I'm stuck in sadness too often.  I think so much of the depression relates to how well the rest of your life is going. We are struggling financially and vocationally. I know I've lost a lot of confidence these last few years and the smallest task just feels like a big event. I know this isn't me.  

My dr. suggested trying Effexor XR, but what I read on forums about those side effects concerns me. I guess it's a decision between two evils.

If I could ask, what has worked for you? It would be a big help.

Thank you

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Comments

  • momoschki
    momoschki Member Posts: 682
    edited December 2011

    Everyone is different, of course, but for me, Wellbutrin seems to be working.  I have been on it about a month now, and I can say that at least I don't feel on the verge of hysteria all the time, like I did previously.  I was hesitant to try an SSRI because of side effects.  The Wellbutrin is not associated with weight gain or sexual SE's.  So far, so good.

  • mdg
    mdg Member Posts: 3,571
    edited December 2011

    I am on Lexapro and that works well for me.  It even helped reduce my hot flashes from tamoxifen!

  • flash
    flash Member Posts: 1,685
    edited December 2011

    lexapro worked well for me.  It is annoying to try to figure out what will actually work.  I hope all goes well foryou.

  • CharB22
    CharB22 Member Posts: 310
    edited December 2011

    I've been on Lexapro for 5 years having started it waaaay before BC. The only SE with that has been weight gain. But it's been a huge help. After the BC dx, I started on Xanex to help with the anxiety of it all. That's been great too -- the tears and doom/gloom outlook has finally subsided.

  • exbrnxgrl
    exbrnxgrl Member Posts: 12,424
    edited December 2011

    I used to take Celexa to help with moodiness and hot flashes during menopause, before BC. Shortly after dx, I began taking Effexor and have used it for 10 weeks. No SE's so far.

    Caryn

  • marilyn113
    marilyn113 Member Posts: 118
    edited December 2011

    I switched to Effexor XL a couple months ago along with Wellbutrin.  (My old anti-depressant wasn't working well anymore.)  It's working good for me.  If you hope to go off anti-depressants some day, I would ask your doctor about Effexor withdrawl symptoms.  I've struggled with depression and PMS since I was a teenager so I'll never go off them.  I don't know how anyone handles cancer without happy pills!

  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2012

    I have taken an antidepressant for years, but I think the real healing for me was several years of INTENSE work, "talk therapy" with a well trained therapist.  I know some can do it with just medicaiton, but I needed both.  A good psychopharmacologist can give you all the information about the carious medications available now.

    Agree with Char - weight gain is a very, sadly VERY, common SE of all the antidepressants. Combined with an aromatase inhibitor, ugh!  But a very HAPPY HAPPY ugh Wink

  • Moderators
    Moderators Member Posts: 25,912
    edited December 2011

    There's an article at the main Breastcancer.org site that talks about antidepressants, as well as considering the possible causes of depression, and some of the complementary approaches to managing depression.

    Judith and the Mods

    .

  • mrsnjband
    mrsnjband Member Posts: 1,409
    edited December 2011

    I've been on Lexapro for 2 years & it has made a big difference.  I tried zoloft but it didn't work for me, actually made me worse. Hope you find something that works for you. NJ

  • SyrMom
    SyrMom Member Posts: 862
    edited December 2011

    Why can't you take an antidepressant if you are on an Al?  Where could I find out more information on this?

  • DivineMrsM
    DivineMrsM Member Posts: 9,620
    edited December 2011

    This is such a great topic.

    Over about a seven month period, I tried four different antidepressants, prozac, zoloft, remeron, and effexor. They left me what is called "flat" which means I just zoned out and all I could do was sit on the sofa and do absolutely nothing.  They also increased my anxiety. 

    It sounds weird, but it took me a number of months to pinpoint what exactly I was feeling emotionally.  I realized it was my great anxiety (not because of the antidepressants) that needed addressed, not necessarily depression.  I would physically be trembling and had difficulty functioning due to the anxiety. I was given a prescription for Buspar, an anti anxiety med.  It has been wonderful.  I only wish I'd received it sooner.

    What I especially love about Buspar is it does not make me tired in the least, which Ativan does.  It just calms me.  But I am not 'zoned out' at all.   It is not addicting, either, which I'm told Ativan is, and the doctors I have simply won't continue to prescribe Ativan due to its addictive properties.

    Also, I was prescribed a small dose of Buspar, with the option to  have it increased if necessary as it seemed that I was rather sensitive to these types of medicine.  I found taking 15 mg a day seems to help most.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited August 2012

    Syr  you can take an antidepressant with an AI - -just can't take certani ones with tamoxifen.

    Difficulty for me, most AI's have an SE of "weight gain" as do most antidepressants - but it's definitely WORTH it - fat AND happy!

    Hope all had a wonderful holiday

  • Reality
    Reality Member Posts: 782
    edited December 2011

    I find that Prozac has worked well for me. I honestly feel no side-effects, except that I absolutely cannot cry, no matter how sad I am. That was hard to get used to at first - in fact, my oldest grandson said that he was glad I do not cry all the time anymore, but that it must hurt when you need to cry and cannot. In addition, Prozac actually helps me curb my nervous eating tendancies.

  • vivirasselena
    vivirasselena Member Posts: 278
    edited December 2011

    Prozac.......4 dollars a month. I've been on it without any problems for years.

  • SyrMom
    SyrMom Member Posts: 862
    edited December 2011

    Thanks for the clarification. Have you had any skeletal pain with the Al's?

  • Baxter
    Baxter Member Posts: 234
    edited January 2012

     Thanks for the info ladies. I'm not taking Tamoxifen so I guess I can take any AD. I started Prozac about 6 days ago. I know that's an SSRI as well and I've tried several of those before, but I guess they must all be a little different.

    I really hope this works for me. I know it takes weeks before you see any results. Hoping for no side effects. I just really need to start feeling better and be part of life again.

  • Sierra
    Sierra Member Posts: 1,638
    edited January 2012

    Celexa

    taken some years ago

    Sierra :)

  • mamalu13
    mamalu13 Member Posts: 35
    edited January 2012

    Sierra

    I just recently started taking Xanax and they just put

    Me on celexa. Do you know anything about any

    Of these. I hate taking any kind of meds but I am

    Really hoping these work. I feel like I will never

    Feel like myself again. The Zanex males me very tired.

  • Ellie1959
    Ellie1959 Member Posts: 316
    edited January 2012

    Cymbalta is my drug of choice - I have mad chronic pain as well as other issues and it is a Godsend. I think it might interact with tamoxifen - you might want to check that out- Good Luck!

  • Wren44
    Wren44 Member Posts: 8,585
    edited January 2012

    I have recurrent Major Depressive Disorder and have been on many anti-depressants. I'm currently taking Wellbutrin, which has been the best. I took Effexor for a couple of years and was able to wean off without any side effects. You do have to go off gradually.

  • flannelette
    flannelette Member Posts: 984
    edited January 2012

    I think Prozac's great. But you have to move upward slowly or you might feel really speedy at first - like wayyy too much coffee. when I was really low, had been on remeron, it wasn't working, my pharmacist, who I think knew way more about this stuff than my doctor, suggested I take 40 mg prozac per day (tthat's 2 times the standarrd 20 mg pill) plus Risperdel, which is an atypical antipsychotic. risperdel "boosts" the Prozac , it has been found. I told my dr her suggestion, dr did what she said. Rocketed me out of very deep depression in about 2 weeks flat. ZOOM! hang on for the ride.

  • mamalu13
    mamalu13 Member Posts: 35
    edited January 2012

    That's my problem . The xanax is to controll my

    Anxiety which gives me major shaking where I canNot

    Even sit still for 5 min and I can't stop crying. It seems

    To help but it makes me so tired. I may have to switch to

    Something else. First day on my celexa and no

    Side affects yet. But they don't me it will take 4 weeks

    To start working. I'm just curious if these meds alter

    The way you feel like a zombie. That's what I don't want.

    I just want to feel like my old self and laugh again.

    Everything I can think about is gloom and doom and

    Whether this will come back. I'm a complete basket case

    I have a great support system and I feel quilty for taking

    Them along for the ride.

  • flannelette
    flannelette Member Posts: 984
    edited January 2012

    I did nt like Xanax either - found it just womped me, let me sleep, have a short period of normal - like an hour, then wore off. I like clonazapam MUCH better. Seems to be more gentle yet lasts longer - but I haven't had the major anxiety your'e having while on clonazapam. Xanax was effective ut th zombie thing was awful...when i needed all those drugs in a big way I also had massage, talk therapy, and took a class for 12 weeks called Stress Reduction and Relaxation - the couse devised by Jon Kabat-Zin. The guided body scan was the BEST, also slow, gentle , simple yoga postures before sleep. At that point I couldn't drive a car, be alone at night, or go outside at night, and it was sheer hell, except I thought if I had to pick one, it would be anxiety over depression any day. I had them concurrently and was incapacitated for close to a year.

    I got a copy of Full Catastrophe Living by Jon Kabat-zinn and it was so fu of compassion, it understood me so well, it had such love to offer, I would fall asleep with it in my arms. It was my lullaby. ps is there anyone to rock your feet, get your whole body gently rocking while you lie down, and sing you a lullaby? 

  • DivineMrsM
    DivineMrsM Member Posts: 9,620
    edited January 2012

    flannelette, the book you mention: Full Catastrophe Living, sounds intriguing, and I am going to get it from my library and read it.

  • mamalu13
    mamalu13 Member Posts: 35
    edited January 2012

    I don't think I can handle Xanax it makes me so tired I can function and I only took celexa for two days cause it made my heart race really fast . Now back to doc.. What side affects have you all experienced with the Wellbutrin ? I just want the shakes to go away. Then I can deal with the depression. But the anxiety seems to be worse for me.

  • DivineMrsM
    DivineMrsM Member Posts: 9,620
    edited January 2012

    mamalu, 

    One main reason I like the Buspar, which is an anti-axiety medicine, is because it does NOT make me tired.  I have found it to be VERY effective in helping me with my anxiety.

    It doesn't make my heart race, or make me feel like sitting on the sofa all day doing nothing.  It helps me go about my day in a regular kind of way. 

    Last summer, my anxiety levels were so high, my whole body trembled every day.  It was similar to the way your body would shiver if you were out in the freezing cold without a coat on.

    If you read my 1st post on this thread, it explains more, and sounds similar to what you're experiencing.

    The Buspar does NOT make me feel like a zombie.  It just helps with the anxiety.  I still laugh about things, bitch about other things.  And the buspar began helping aleve the anxiety the first day I took it.

  • carcharm
    carcharm Member Posts: 486
    edited January 2012

    Klonapin is a long acting xanax. It does not make me tired or have a racing heart. I am also on cymbalta. I haven't been taking it long enough to decide if it works well.

  • mamalu13
    mamalu13 Member Posts: 35
    edited January 2012

    Do you know if klonapin is addicting like Xanax . I hate Xanax. I only take it when I really need it but I'm suffering all day with the shakes and anxiety.

  • carcharm
    carcharm Member Posts: 486
    edited January 2012

    Unfortunately it is addictive but I take it under watch by a psychiatrist. I take it for anxiety but I also take it to realx my muscles. Since chemo I have horrible muscle cramps, twisting, daily and it does help me not to get panicky when they come on. I can't take xanax. It makes my heart palpitate and I get even more restless. It sounds like you could use something even for a short term.

  • mamalu13
    mamalu13 Member Posts: 35
    edited January 2012

    What about bulspar.. Does anyone know anything about that drug. I hear that's not addicting.

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