Ki-67 Significance - pre surgery

My Ki-67 was 61% and so far no problems 2 yrs 9 months out from dx. It worried me also when I googled the studies, but I think that the medical community has decided that it is not a significant marker for progession.

 Good luck with the waiting and your surgery. I know this is the hardest part. Once you get past the start of "active" treatment you can feel like you're doing something and the worries ease somewhat.

Hugs!

Hi TexasRose,

I asked my oncologist about my Ki-67 score since there was none listed on my post surgery path report.

He said it is not considered significant for progression.  He is at a major teaching/research hospital so he should be  up on the latest research.

Having said that, I don't really know what the significance of ki-67 is.

Have you had an oncotype test?

Take good care! 

My ki-67 was 70%. My mitotic rate was only a 1. I think Ki is some kind of indicator of what percentage of cells are in the process of dividing. How I could have had a mitotic rate of 1 and such a high Ki is a mystery to me. It is the only thing about my cancer I could never figure out. But I have done pretty well for a long time, so take heart, all you guys with high Ki's.

My Ki-67 was 76%. With grade 3 IDC, this pretty much made chemo a slam dunk for me. I'm doing well...almost two years out. I was so worried and shocked when I heard how high my Ki-67 was on the initial pathology report. Now, I figure it is a piece of the puzzle, but not the whole picture.  Don't let it overwhelm you...things get better. What caused night sweats and panic two years ago, don't cross my mind anymore. You will, step-by-step, figure this all out. Warm thoughts to you for a successful treatment plan!

TexasRose2127 ~  HI, my k-67 was mentioned on the first pathology findings following my disgnostic mammo and FNB.  I was listed as follows:

Kl-67 Proliferation Index1    Low Proliferation                Reference Range

                                             % nuclei stained = 8.8         < 10% =Low

                                                                                        10-20%=Borderline

                                                                                          > 20%=High

So, I read the report to mean I had cells that were Low Proliferation or slow growing. From the way I am reading the reference range on my report Less than 10% is Low, Borderline is 10 -20%and High is more than 20%,  I am confused as to the whole big picture, especially my ER+ is 100%,and Progesteron is 88%

Barb

A recent paper from the British Journal of Oncology says there IS a strong linear compenent to Ki67 and OncotypeDX but the fussiness is the "intermediate". A person with a low Ki67 score can sometimes have an intermediate risk, but mostly if you have a high ki67 you have a high oncotypeDX score.....but not always. Fun eh? In B.C. Canada, they don't fund the oncotypeDx so I'm stuck with the Ki67 (low less than 10%) and I'm happy enough with that. That being said, NO..it doesn't have much to do with survival because high proliferating tumors respond well to chemo while slow growers can show up years down the pike as a recurrence. Fun eh?

Granny had Ki67-30% but very high mitotic index - 30/10HPF, after neoadjuvant treatment 15/10HPF