Mammosite Rad vs. 6 wk Rad.??
I would like to know the pluses and minus of having the mammosite radiation vs. regular 6 1/2 weeks of external radiation other than the time frame? I am having surgery for a 8mm. lesion in the left breast. The doctor has given me the choice of mammosite vs. regular radiation, if the margins are clear and there is no lymph node involvement. I have heard that some people have a lot of discomfort after the mammosite, even developing cysts, etc. It the same true with the 6 week treatment? Which would you suggest?
Comments
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There are plusses and minuses to both. I don't think I've ever read of someone having Mammosite (or Savi, or Contura) who was sorry she did that instead of WBI. But I've read remarks from a lot of women who had WBI who wished they could have had Mammosite.
If you have Mammosite you won't be able to shower while it's in place, and there's some discomfort involved. I've suggested to some women that they plan to go to a salon and get their hair washed one or two times while the balloon is in place.
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Thanks for your insight, I really am new to all of this and of course want to make the right decision. It seems like it would be the most practical of all courses to take, but again I am not sure about the side effects of this treatment.
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In trying to decide for myself, I learned from my radiation oncologist that although mammosite is showing the same results as whole breast radiation, the difference is being somewhat age dependant. What was explained to me was that we have had mammosite available almost ten years, and initially it was done on women either 60 or 65 years old and older. As it proved successful, they would lower the age that would be eligible. I am 48 years old, and he said that we have much more data available showing the effectiveness of older women and not much long term data proving effectiveness for younger women. He felt that ten years from now we will probably see that it will be as effective as whole breast radiation, but for now the data is not there. Whole breast radiation has been done and studies to prove its effectiveness has been done for decades now. Although, mammosite would certainly have been more convenient, I decided for whole breast radiation. I even asked him if it were his wife and she was my age which would he prefer her to get, his response was he would want he to have whole breast radiation.
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I'm going to guess that 1942kathy was born in 1942, making her about 69 years old.
Kathy, the potential side effects of traditional radiation are pretty scary. Check out these pages: http://community.breastcancer.org/forum/70/topic/709343
http://community.breastcancer.org/forum/70/topic/770374
http://community.breastcancer.org/forum/70/topic/773346
http://community.breastcancer.org/forum/70/topic/773918
http://community.breastcancer.org/forum/70/topic/704224
http://community.breastcancer.org/forum/70/topic/774167
http://community.breastcancer.org/forum/70/topic/766012
And the list goes on and on. I don't think I included any in which women got broken ribs after radiation, Shingles, or heart problems, but those too are possible SEs from WBI.
By contrast, the SEs from Mammosite are discomfort with the balloon while it's in place, and the possibility of a seroma (not a true cyst). Seromas can happen with any type of breast surgery, whether or not there's radiation, but develop somewhat more commonly with Mammosite-type radiation.
Give me seromas over broken ribs, shingles, or pleurisy any day of the week!
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1942Kathy - I am 56 and was offered Mammosite rads last year after my lumpectomy. My BS inserted the balloon catheter in his office in about 20 minutes and I was off to the RO for my simulation. After trying for 3 days to get the balloon to fit properly in the lump cavity - we had to pull it out and proceed with whole breast rads. Even though mammosite rads have been available for many years, in some places it is still considered experimental. There is not enough information out there yet. You have to meet certain criteria to even be eligible. The actual success rate is not high as there are other factors that can get in the way - infections, etc. Once the balloon was removed, I had to wait an additional 3 weeks for the scar to heal before I could get started. Bottom line is the decision is entirely yours and I am certain you will make the one that you feel is the best for you.
An additional note: I did 30 rad treatments and did not have too many side effects. I did get a bit red - expected that as I am light skinned. I do have permanent nerve damage from rad treatments but this can also happen with the mammo rads. Please PM me anytime if you would like to hear more of my story.
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Accelerated Partial Breast Irradiation (APBI) -- Mammosite is one method -- is a newer technology with shorter follow-up data than whole breast irradiation and is usually recommended only to patients at low risk who meet specific conditions. The rationale is that the area nearest the tumor site has the highest risk of recurrence so treating just that area with radiation therapy will reduce the rate of recurrence in the area at highest risk. The rest of the breast, which is treated with whole breast irradiation but not with APBI, does have some risk of recurrence, but for carefully selected patients that risk may be quite low.
The following article describes guidelines from the major professional society of radiation oncologists for APBI based on the data available.
http://www.redjournal.org/article/S0360-3016(09)00313-7/abstract
Criteria for being "suitable" for APBI include patient age >= 60 years old, no BRCA 1/2 mutation, tumor size <= 2 cm., Stage T1, margins negative by at least 2 mm., no lymph-vascular space invasion, ER+, unicentric only, clinically unifocal with total size <= 2 cm., invasive ductal or other favorable histology, not pure DCIS, no extensive intraductal (i.e. DCIS) component, pathologically node negative, sentinel node biopsy or axillary lymph node dissection. The article goes on to loosen some of those criteria in defining a "cautionary" group for whom APBI may be considered, as well as a group of patients for whom APBI is "unsuitable".
Some radiation oncologists are more favorably inclined toward APBI than others and use of these guidelines, especially for the "cautionary" group will vary.
Accelerated Whole Breast Irradiation (AWBI) is another option that treats the whole breast in 3-4 weeks with larger daily fraction doses than the traditional ~6 week plan. That option has been widely used in Canada for many years.I chose traditional whole breast irradiation because I wanted to treat the whole area at risk and because I wanted the lower daily dose over time. Radiation works by disrupting the process of cell division. Normal cells can respond and repair themselves better than cancer cells but radiation kills cells over time at the critical stage of cell division. I wanted to give the radiation time to work to combat the cancer biology. Still, I don't think there is a magic to 6 weeks and I do think accelerated plans such as AWBI can work well.
I had some tan/pink skin and some fatigue during treatment but the side effects were minor. If you search these boards you will find numerous threads discussing both Mammosite treatment and traditional radiation therapy and you can make your own judgment.
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My onc pointed out that tumors are not always perfectly shaped to get equal doses of radiation w/ mammosite. But if there is another tumor in the same breast, the mammosite can possibly be repeated, while the whole breast rad cannot. Also, where was the tumor? Was it close to the chest wall or not? How much of the chest will be involved? No answers
here but those are some of the considerations I made. Good luck with your surgery and your decision.
ps. My onc said the same thing, that mammosite may ultimately be the standard of care but he said that it was approved for use as a "procedure" which means it "does no harm" and that docs can charge for putting it in and taking it out.
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I had Mammosite last July. It was not painful, I had no problem with the catheter site, and I healed completely without any issues. But, I had a big, bad, ugly recurrence in the same breast, in an area above the original tumor bed. It's possible it was "leftovers" that might have been caught with either a mastectomy or external radiatin. No one will ever know. I was 60 at the time.
If there is any current information out there about recurrence after Mammosite, it's pretty well-hidden.
Michelle
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I finished brachytherapy a week ago. I meet all the criteria listed in the post above by redsox except that I am only 58. My extremely experienced breast surgeon believes that for women like me, it has the best chance of knocking out any leftover tumor cells (in spite of my good margins) while not attacking healthy cells, skin cells, and lymph nodes.
To answer a couple of specific issues raised above, I would say that if you are going to do this, do it with a surgeon who's experienced with it and has the ultrasound to guide placement of the balloon catheter. The wires are placed inside the balloon in a way to avoid irradiating the ribs or inside of the skin. I would absolutely ask about their infection rate. My radiation oncologist hasn't had an infection for three years. You don't want to take any more risk than you have to -- this thing is like a freeway into your chest, an open wound for 5 days.
It is very efficient, and I would definitely do it again, rather than external radiation. That is partly because of work considerations... 6 or 7 weeks of 5x a week would have been terribly hard for me.
However, I underestimated how much the process would bother me. A steady regimen of ibuprofen (ask your doctor how many to take) was necessary for me to manage the constant mild discomfort. I had someone drive me on the first couple of days and that was important... Day One was exhausting (my husband said it lasted a month and I agreed). I didn't sleep very well with the catheter in me and sticking out one side. From the combination of that and the radiation, I was fatigued on Days 4-5 and through the weekend. Other than tiredness, the actual treatments after Day One are very quick and painless. At a week or so after finishing treatment, and about 3 weeks after my lumpectomy, I've just about got my energy back.The insertion site has been very healthy the whole time and it's healing up but the area is still tender and I'm still taking ibuprofen for it.
Good luck with your decision and all your treatment. I hope this helped.
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I did Accelerated Partial Breast Radiation.
Did it on the right side, after mammosite failed due to infection (make sure they give you an antibiotic)
Twice a day for one week.
My skin turned pink.
I didn't have to drive through rush-hour traffic for 6 weeks
So far, no recurrences
Highly recommended.
Sue
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I just finished my 5-day treatment with the SAVI. I am so glad i chose this instead of traditional 6-week radiation. I was the first patient at IU in Indianapolis to receive treatment with the SAVI and two reps from the company came and oversaw my treatment. No pain from putting the device in, no pain from the treatment and no pain upon removal. One of the disadvantges of the MAMMO site is they can't custom design your treament. It radiates the whole tumor space. My SAVI had nine individual cathethers and each one was custom programmed to my tumor. If it is close to the skin I believe they can even not send radiation to that catheter.
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The one I had is called Contoura and it has 4 different wires that are programmed to irradiate the breast tissue areas and not the ribs, skin, etc. They all come in through the one catheter.
I agree, I'm glad I did this instead of longer-term, lower-dose radiation.
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