Guinea pigs, are we ?
Comments
-
My final path report after BMX showed multiple areas of DCIS that had never been detected by the 3 mammograms, 2 US and 2 MRI's I had. I didn't even know that was possible!
-
Kate, will DCIS always develop into invasive ? Do they know it as an absolute fact ? My tumours had in situ "aspect", did something happen at one point, maybe mammo, that turned the in situ status into invasive status. Don,t know....
-
At my last mammogram I was asked to participate in a study of new technology, 3D ultrasound, because I have dense breasts. It produces highly detailed, sliced images of the breast. Maybe one day this will be the standard of care.
-
After a routine mammogram detected my 2.2 cm IDC, I had an MRI before a lumpectomy. My surgeon called with odd results - she said that if she didn't know better, the MRI showed that there was no cancer in the breast. I thought that was good - she wasn't so sure. I had a lumpectomy with dirty margins (DCIS in 2 ducts), another lumpectomy (which turned up another .7 cm IDC and more DCIS), then a mastectomy (only a few residual cancerous cells left in the cavity.) My onc said that about 2% of tumors don't show up on MRI.
The 3D ultrasound sounds promising ( and much less painful and nerve-wracking than a mammo or MRI.)
-
Luan- DCIS will not always become invasive. Unfortunately, they can't research to find out why some do and some don't because anyone DX with DCIS isn't willing to let it sit in there long enough to find out. I did read that a woman can have DCIS her whole life and it never grows at all. They only discovered this in autopsies.
3D US sounds wonderful! I always found mammograms to be extremely painful. It's about time they came up with a better solution that squishing our boobs into a trash compactor!
-
Joy, you asked what determined my stage III status. I am trying hard to determine what testing positive for E-cadherin means, as well as others on the E-Cadherin thread. Maybe you could join us there, as I think I might have read somewhere that you referred to it and sounded familiar with it ? The way I interpret this issue is that one would test positive for loss of E-cadherin, am I wrong?
"Decreased expression of E-cadherin in tumor cells has been shown to correlate with increased invasiveness in vitro, increased metastasis in murine models, and adverse clinicopathological characteristics in numerous human cancers"
Do I really want to know ?
-
LUAN,
You're obviously having a very difficult time understanding what positive and negative means in regards to E-cadherin testing. Let's try this again -
E-cadherin is a cell surface protein and is present on normal breast tissue. The test for E-cadherin is done using a stain to highlight the presence of those E-cadherin proteins. When the pathologist drops the stain onto the slide containing the cancer cells and those cells then change color, that color change means that the test is POSITIVE. A positive test result means that E-cadherin is present. The test is positive for E-cadherin.
The term "loss of E-cadherin" means that the tumor cells have none or very little E-cadherin protein present. If the slide does not change color when the stain is applied to it, then the test result is NEGATIVE for E-cadherin and there is "loss of E-cadherin".
ILC tumors generally tests negative because they have lost their E-cadherin proteins. IDC cells almost always retain their E-cadherin proteins, so they test positive.
Does it make more sense to you now?
-
Yes, not all dcis will become invasive because not all dcis are alike. Lower grade cancer cells take longer (even a life time) to become troublesome, or invasive. From what I learned about dcis is that the grade 3, high grade cells are more likely to become invasive. The high grade cancer cells do not look like normal cells. The high grade cells that becomes solid must either burst from the ducts or travel up or down the ducts. The person dx with high grade dcis is at high risk for invasive cancer. It is a matter of time no matter what age they are.
Basically, those who have lower grade dcis are the ones in question to whom will or will not be dx with invasive cancer. High grade dcis is a sure thing that is if it is left alone.
From BCO
Grade I (low grade) or Grade II (moderate grade)
Grade I or low-grade DCIS cells look very similar to normal cells or atypical ductal hyperplasia cells. Grade II or moderate-grade DCIS cells grow faster than normal cells and look less like them. Grade I and Grade II DCIS tend to grow slowly and are sometimes described as "non-comedo" DCIS. The term non-comedo means that there are not many dead cancer cells in the tumor. This shows that the cancer is growing slowly, because there is enough nourishment to feed all of the cells. When a tumor grows quickly, some of its cells begin to die off.
People with low-grade DCIS are at increased risk of developing invasive breast cancer in the future (after 5 years), compared to people without DCIS. Compared to people with high-grade DCIS, however, people with low-grade DCIS are less likely to have the cancer return or have a new cancer develop. If more cancer does develop, it typically takes longer for this to happen in cases of low-grade DCIS versus high-grade.
Grade III (high-grade) DCIS
In the high-grade pattern, DCIS cells tend to grow more quickly and look much different from normal, healthy breast cells. People with high-grade DCIS have a higher risk of invasive cancer, either when the DCIS is diagnosed or at some point in the future. They also have an increased risk of the cancer coming back earlier - within the first 5 years rather than after 5 years.
-
I am really interested in the 3 D ultrasound. I'm a good size B right now, except for on and off swelling in the left breast (I think I have slight left breast lymphdema), which is another reason to be concerned about a mammogram.
-
MarieKelly, thanks, but i am no chemist....and that girl on that thread said that her onco told her that being negative was a good thing. So yes i,m having a hard time understanding this in my second language. I could very well test pos for loss of e cadherin, if u follow my deduction. I did find today something that backs up what u say, so again thank you
-
Evebarry, thank u so much for your trouble. Could i transpose your explanation on the grades to my IDC and conclude that because it was grade 1 that it,s been hanging around a looong time. I was scared that because of its relatively small size that it had done quite a bit of damage : had a smaller sister close by, had invaded 2 nodes, one of which had extra capsular extensions. Maybe i was wrong in thinking that it was "agressive". My onco refuses to qualify it for me.
I,m with you on the mammo and lymphedema in left breast also((
-
Yes we are guinea Pigs.Period!!!!!
-
Grannydukes, well said LoL !!
-
And im not happy about it either!!!!!!!!
-
Luan, feel free to transpose anything I've posted on bco. Whatever is here is public info
Plus the information about grades is here on bco and other well known cancer sites.
Your cancer, grade 1 has been around for a loooong time
I read one place that an invasive grade 1 trumps the dcis grade 3. Once it's moved outside the ducts it's dangerous.
Categories
- All Categories
- 679 Advocacy and Fund-Raising
- 289 Advocacy
- 68 I've Donated to Breastcancer.org in honor of....
- Test
- 322 Walks, Runs and Fundraising Events for Breastcancer.org
- 5.6K Community Connections
- 282 Middle Age 40-60(ish) Years Old With Breast Cancer
- 53 Australians and New Zealanders Affected by Breast Cancer
- 208 Black Women or Men With Breast Cancer
- 684 Canadians Affected by Breast Cancer
- 1.5K Caring for Someone with Breast cancer
- 455 Caring for Someone with Stage IV or Mets
- 260 High Risk of Recurrence or Second Breast Cancer
- 22 International, Non-English Speakers With Breast Cancer
- 16 Latinas/Hispanics With Breast Cancer
- 189 LGBTQA+ With Breast Cancer
- 152 May Their Memory Live On
- 85 Member Matchup & Virtual Support Meetups
- 375 Members by Location
- 291 Older Than 60 Years Old With Breast Cancer
- 177 Singles With Breast Cancer
- 869 Young With Breast Cancer
- 50.4K Connecting With Others Who Have a Similar Diagnosis
- 204 Breast Cancer with Another Diagnosis or Comorbidity
- 4K DCIS (Ductal Carcinoma In Situ)
- 79 DCIS plus HER2-positive Microinvasion
- 529 Genetic Testing
- 2.2K HER2+ (Positive) Breast Cancer
- 1.5K IBC (Inflammatory Breast Cancer)
- 3.4K IDC (Invasive Ductal Carcinoma)
- 1.5K ILC (Invasive Lobular Carcinoma)
- 999 Just Diagnosed With a Recurrence or Metastasis
- 652 LCIS (Lobular Carcinoma In Situ)
- 193 Less Common Types of Breast Cancer
- 252 Male Breast Cancer
- 86 Mixed Type Breast Cancer
- 3.1K Not Diagnosed With a Recurrence or Metastases but Concerned
- 189 Palliative Therapy/Hospice Care
- 488 Second or Third Breast Cancer
- 1.2K Stage I Breast Cancer
- 313 Stage II Breast Cancer
- 3.8K Stage III Breast Cancer
- 2.5K Triple-Negative Breast Cancer
- 13.1K Day-to-Day Matters
- 132 All things COVID-19 or coronavirus
- 87 BCO Free-Cycle: Give or Trade Items Related to Breast Cancer
- 5.9K Clinical Trials, Research News, Podcasts, and Study Results
- 86 Coping with Holidays, Special Days and Anniversaries
- 828 Employment, Insurance, and Other Financial Issues
- 101 Family and Family Planning Matters
- Family Issues for Those Who Have Breast Cancer
- 26 Furry friends
- 1.8K Humor and Games
- 1.6K Mental Health: Because Cancer Doesn't Just Affect Your Breasts
- 706 Recipe Swap for Healthy Living
- 704 Recommend Your Resources
- 171 Sex & Relationship Matters
- 9 The Political Corner
- 874 Working on Your Fitness
- 4.5K Moving On & Finding Inspiration After Breast Cancer
- 394 Bonded by Breast Cancer
- 3.1K Life After Breast Cancer
- 806 Prayers and Spiritual Support
- 285 Who or What Inspires You?
- 28.7K Not Diagnosed But Concerned
- 1K Benign Breast Conditions
- 2.3K High Risk for Breast Cancer
- 18K Not Diagnosed But Worried
- 7.4K Waiting for Test Results
- 603 Site News and Announcements
- 560 Comments, Suggestions, Feature Requests
- 39 Mod Announcements, Breastcancer.org News, Blog Entries, Podcasts
- 4 Survey, Interview and Participant Requests: Need your Help!
- 61.9K Tests, Treatments & Side Effects
- 586 Alternative Medicine
- 255 Bone Health and Bone Loss
- 11.4K Breast Reconstruction
- 7.9K Chemotherapy - Before, During, and After
- 2.7K Complementary and Holistic Medicine and Treatment
- 775 Diagnosed and Waiting for Test Results
- 7.8K Hormonal Therapy - Before, During, and After
- 50 Immunotherapy - Before, During, and After
- 7.4K Just Diagnosed
- 1.4K Living Without Reconstruction After a Mastectomy
- 5.2K Lymphedema
- 3.6K Managing Side Effects of Breast Cancer and Its Treatment
- 591 Pain
- 3.9K Radiation Therapy - Before, During, and After
- 8.4K Surgery - Before, During, and After
- 109 Welcome to Breastcancer.org
- 98 Acknowledging and honoring our Community
- 11 Info & Resources for New Patients & Members From the Team