Derived from a tree in the rain forests of Africa, South America, and Southeast Asia. The bark, leaves, root, and fruits have been used as traditional remedies in many countries. Extracts of graviola have been shown to have antiviral ⁽¹⁾, antiparasitic, antirheumatic, astringent, emetic ⁽²⁾, antileishmanial and cytotoxic ⁽³⁾⁽⁴⁾ effects. Graviola has also been shown to be effective against multidrug resistant cancer cells line ⁽⁵⁾⁽⁴⁾. There are no large scale studies in humans on the effects of graviola. Alkaloids extracted from graviola may cause neuronal dysfunction and degeneration leading to symptoms reminiscent of Parkinson's Disease ⁽⁶⁾.