L-Carnitine

Here is what I read

From The American Journal of Gastroenterology
L-Carnitine Supplementation to Diet: A New Tool in Treatment of Nonalcoholic Steatohepatitis-A Randomized and Controlled Clinical Trial

Mariano Malaguarnera AP; Maria Pia Gargante MD; Cristina Russo MD; Tijana Antic MD; Marco Vacante MD; Michele Malaguarnera MD; Teresio Avitabile; Giovanni Li Volti AP; Fabio Galvano AP

Posted: 01/17/2011; Updated: 01/16/2011; The American Journal of Gastroenterology © 2010
Abstract and Introduction
Abstract

Objectives: Nonalcoholic steatohepatitis (NASH) is a known metabolic disorder of the liver. No treatment has been conclusively shown to improve NASH or prevent disease progression. The function of L-carnitine to modulate lipid profile, glucose metabolism, oxidative stress, and inflammatory responses has been shown. The aim of this study was to evaluate the effects of L-carnitine's supplementation on regression of NASH.
Methods: In patients with NASH and control subjects, we randomly dispensed one 1-g L-carnitine tablet after breakfast plus diet and one 1 g tablet after dinner plus diet for 24 weeks or diet alone at the same dosage and regimen. We evaluated liver enzymes, lipid profile, fasting plasma glucose, C-reactive protein (CRP), tumor necrosis factor (TNF)-a, homeostasis model assessment (HOMA)-IR, body mass index, and histological scores.
Results: At the end of the study, L-carnitine-treated patients showed significant improvements in the following parameters: aspartate aminotransferase (P=0.000), alanine aminotransferase (ALT) (P=0.000), ?-glutamyl-transpeptidase (?-GT) (P=0.000), total cholesterol (P=0.000), low-density lipoprotein (LDL) (P=0.000), high-density lipoprotein (HDL) (P=0.000), triglycerides (P=0.000), glucose (P=0.000), HOMA-IR (P=0.000), CRP (P=0.000), TNF-a (P=0.000), and histological scores (P=0.000).
Conclusions: L-carnitine supplementation to diet is useful for reducing TNF-a and CRP, and for improving liver function, glucose plasma level, lipid profile, HOMA-IR, and histological manifestations of NASH.

lago, that is good to hear. I take Lyrica for my neuropathy but I had

paraneoplastic syndrome as a result of the breast cancer tumor and

some of the neuropathy stayed with me...

Liz, I just started taking it Sunday...waiting to hear also

Liz

I saw that article above in Medscape.com so wanted to follow up

on it...my liver problems started as NASH after my miasma

of breast cancer chemo ( CMF) ( methothrexate can be

very toxic to the liver), tamoxifen, arimdex and

vicodine for the bone pain from neupogen..then it went

to CASH then cirrhosis...lucky me..my doctors tell me it will

not ever get better, the goal is not to have it get worse.

I also have neuropathy, but the Lyrica really really helps me with that

I saw this today on Medscape.com

Table 2. Medications and Therapies Associated With NAFLD
Coralgil
Perhexilene maleate
Amiodarone
Thiazolidinediones (glitazones)
Total parenteral nutrition
Chloroquine
Tamoxifen
Glucocorticoids
Calcium channel blockers
Estrogens
Diethystilbestrol
Methotrexate
Thioridazine
Lamivudine
Valproic acid
Tetracyclines