Stress & Cancer
http://www.latimes.com/health/os-stress-sabotages-chemotherapy-20100922,0,3482770.story
Even when radiation had damaged the cancer cell's DNA, the cells avoided death when heat shock factor-1 was around, turning on another partner-in-crime protein that protects cancer cells from harm.
Cancer grows as cells divide and multiply. The stress-induced protein allows damaged cancer cells to pause, repair themselves and continue dividing.
I've read also that stress can trigger cancer cells into making tumors. Could stress be the number one factor in cancer?
Comments
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I wouldn't be surprised if that's how I had got my cancer. I absolutely believe in the power of stress make the body sick. We should all be mindful of doing everything to preserve the best mental health we can as part of our treatment. Not that un-stress "cures" cancer - I do not believe that, but the absence of stress could serve as a building block to help prevent recurrence.
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Ah, let me get this right... We've been diagnosed with and are in treatment for breast cancer, which in most cases has already involved surgery. And it's serious enough that we still need chemotherapy. And we're not supposed to feel stressed 2 days before our chemo treatments????
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The stress that induces heat shock proteins is physiologic/environmental stress to the cells of the body: abnormally high heat, oxygen deprivation, starvation, dehydration, toxins (ethanol, arsenic, ultraviolet radiation)... or nitrogen deprivation in plants.... serious disruption to the environment that keeps cells alive.
It's not emotional or psychological stress.
So it makes some sense to say "avoid strenuous exercise" since that can raise the body temperature and cause temporary oxygen deprivation and possible dehydration to cells-- but heat shock proteins are not induced by worry -- so don't worry about worrying!
I don't see that it would be a good idea to try (as the article seems to suggest) to find a drug that can inhibit heat shock protein -- I actually think that would be a terrible idea, because the heat shock proteins are also trying to protect HEALTHY cells from being killed or having their DNA damaged by chemo/radiation!
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hmm..well..I'm 5 years out and I exercised daily during chemo and rads. ...power walking.
I also believe that emotional stress is a part this stress in general because emotional stress affects one physically as well.
The exercise actually should be helping to reduce that stress so we are back to less emotional stress that can affect you physically but now we are into physical stress. I think we need to wait for more studies on this topic. I'm not sure about it all...
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In my board certified oncologist's words, "stress kills". As I understand it, stress releases bad chemicals that in excess can weaken the immune system (cortisol?). And isn't cancer all about an immune system that wasn't strong enough to prevent it? I am not a medical professional, but just offering food for thought. Stress = weakened immune system = less protection against cancer cells.
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In a certain portion of women who die from heart disease they find breast cancer that has been lying dormant.
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I always thought stress is a "killer" but if this is so why do they come up with a drug like Arimidex which is supposed to help us survive longer yet can put us in enough emotional stress to have us swinging from the walls! If Arimidex doesn't cause stress, I don't know what does. So maybe there is "good" stress somehow. I sure hope so!
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I just wanted to say my comments were specifically about "heat shock proteins" -- the subject of the article quoted. Emotional stress definitely raises cortisol levels and isn't good. And RavDeb, I agree with you about exercise, too. Like I said, heat shock proteins protect healthy cells, too -- which, as we all know, get damaged by chemo and rads and need to survive!
That article seems like an attempt to "popularize" a fairly arcane scientific finding. The scientific study was of cells in a dish, trying to spell out some basic steps that happen when cells are exposed to chemo and/or rads. I think it's way too early and really off the mark for the investigator to jump to recommendations to "avoid stress two days before chemo." Anyway, the only point I was making was that heat shock proteins are the body's way of trying to protect itself from extreme physiologic/environmental conditions.
Emotional stress is a whole other issue -- but it does not relate to heat shock proteins.
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okay. Interesting....
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I think stress can definitely be a major player in the role of cancer. This is a subject that I've been discussing with other cancer patients lately. I have several stories to share...
I recently caught up with a dear friend (almost like a cousin) that l haven't seen in many, many years because she moved to another State. She developed stage 4 bowel cancer at a dreadful time in her life. She had chemotherapy, radiotherapy, and has a permanent stoma. She was married to a very abusive controlling man...and suffered a great deal of stress, and during that period of her life her mother died. Our mothers were very close...so she feels a maternal connection with my mother, and decided to visit her/us.
I asked her how her health was going. And she said "Well as you can see I've put on a considerable amount of weight." I asked her if her weight situation was bothering her at all, and if she was considering a healthier lifestyle. She said the healthiest thing she ever did in her life was divorcing the control freak! Three years after being diagnosed with stage 4 bowel cancer...she met the man of her dreams. She said he fell in love with her regardless of her situation and they've been living a blissful life ever since. He's a Scotsman and loves his potato dishes and she also loves her food and never bothered to change her eating habits to a healthier one. They have a beautiful home and do a lot of travelling together. She's never been happier. She did say the stoma/bag can get pretty disgusting but after THIRTEEN YEARS ...she's used to it. She does not do any pharmaceutical drugs or any naturopathic alternatives. She eats what she wants...and is simply happy.
It's amazing some of us can do so much in the way of a healthy life style and have reoccurrence...and others don't give a damn and live a long healthy life after cancer. I really believe happiness is key.
Anyway...Second story...
An incredible, highly intellect gentleman I know developed late stage Multiple myeloma...and was given six months to live. (I've spoken about this before) He managed to finish one round of chemo but felt like it was going to kill him. He had 7 more to go, but decided not to continue. He cut down most of his classes he taught at university, and spent more time at home in a sub-tropical rainforest where he lives with his wife away from the city. He is a vegetarian and takes supplements (turmeric, MSM, essiac tea, spirulina, chlorella...etc) ...he totally believes this helped with his now 12 YEAR survival. He goes for his 6 monthly check-ups and the doctors can't believe he's still with us. He basis his long term survival on a healthy stress free lifestyle, and swears by it.
My story...
Whenever I get REALLY upset...I feel pain in my cancer bed. And I'm not talking about pain post-surgery. I have a wonderful life, and am happy and humble almost always...but like most of us it's had its downs. About five years ago my hubby decided to buy into a business I knew would disrupt the balance at home. I didn't want to start up this business. Although successful it eventually took its toll on our marriage. We separated for six awful months. I cried my heart out every day. I told my mum that when I cry it hurts just above my breast. We eventually reconciled. A year or so later my son was in a car accident and developed a shock related autoimmune disorder. He suffered so much stress...as did I. I felt pain so many times in the same spot, where my cancer bed is/was. I told my parents I hope the pain wasn't going to result in cancer one day...as I was diagnosed with atypical ductal hyperplasia in that same area, five years prior. Well I did develop invasive cancer in 2009...and, well, my life has been wonderful ever since, no dramas. I have been pampered by loved ones, and I'm extremely blessed. But three weeks ago a seedy character decided to rob my home. (my neighbour saw him take off) He took some of my son's personal belongings along the way, as well as other personal things. I was sooooooooooo upset at the mess he left behind. And guess what? I felt pain in the same spot again. I had totally forgotten about the pain in that area...until now. There are many ways of developing cancer. I definitely believe that cells are emotionally charged, and stress is a silent beast that is able to mutate them. Yes I believe stress is a contributing factor Barry.
I'm off for a lovely walk along the beach with my hubby, and pooches.
Have a lovely day ladies...xoxo
Victoria
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Victoria, Yes! I'm not nuts. You're the first person to whom posted that admits pain in the cancer bed when stressed. Most times when stress, I feel pain in the surgical area. It's weird, but it happens.
I also strongly believe that stress is the main cause of our body breaking down. Enough isn't said about stress. We throw everything at cancer, but forget the best medicine is endorfins. I thought that if I'm ever dx with invasive cancer, I'm going to take time off and do something I love...write a novel.
I heard that 2 to 5 yrs before cancer dx, you've gone through some tramatic or stressful event.
I also heard of a story of a man who was given 6 months to live. He went away and wrote a book. He went back to the dr in six month and there was no longer disease in his body. Keeping a positive mental attitude is healing to the body.
Thanks for your comment and stories Victoria...so encouraging. E Barry
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I'm sure a believer for a variety of reasons that stress damages.
I've operated a with hyped up orientation to the world (type A). Put me in a fight (education, staying awake during shift work way back when, fighting for "a cause' for several years in the '90's so on and so forth. Seems like I had to be pushing forward pretty often. I believe I became addicted to the addrenal buzz. No really.
Now I'm 57 and have had to slow down. Body just doesn't like punching forth.
But get this, I had my BMX April 28 '10 (and needed no other intervention, Thank God). Once I healed completely and resumed my life, I found that getting angry or fustrated swells my remaining breast tissue. It swells and feels uncomfortable and I can just imagine what's happening elsewhere.
It doesn't take a rocket scientist, health care provider, or any other expert by whatever means to figure these things out. I feel it's important for anyone to listen to changes of any sort and sit still and let that small voice inform you. Our instincts are a very big deal and informative. Trust 'em.
My current stress that is ongoing is dealing with oil & gas and pipeline guys. If you ever need to do this save some grief and just get a lawyer. After a year, we'll have one by next Wed and he'll do the fighting, wheeling, dealing. My husband has been doing this (very laid back and smart) and I recently decided to help. Big mistake. My posture is upright and firm (oh no, here comes the Mrs.) and to stand up for what remains of property rights. Damages to our property excites me up pretty good.
Continuing to slay dragons the old way, no matter how righteous I might try to spin it will destroy me. No doubt.
I want to live, and be at peace. I've got to chill. It's time.
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I am completely convinced that stress was a triggering factor in my DCIS tumor. I had gone through the emotional trauma of losing four pregnancies late in the first trimester, and the fourth one (August 2008) was absolutely devastating. I lost the will to live and actually prayed to die.
I am also a small business owner, and it became horribly stressful for the next year, because I had no desire to work, got behind on everything, dropped balls left and right, and had customers calling all the time asking where their stuff was, I was chronically stressed out in addition to being utterly depressed. My friend who was diagnosed with stage 2 IDC the year before (at age 36) told me that she felt certain that stress had helped cause it, and I remember thinking, "I'm going to get cancer."
Sure enough, by the summer 2009, I had a palpable lump that turned out to be malignant, but (thank God) only DCIS.
I don't believe stress was the ONLY thing that caused my cancer. I think it can be a triggering factor that can cause it if other pro-cancer factors are present. In my case, during my year of depression and stress, I was also guzzling gallons of Diet Coke (aspartame causes rapid tumor growth), wasn't exercising, was eating garbage (e.g. vegan junk food), was staying up until 3 and 4am or later (lifelong habit which I now know is a cancer risk itself), and gained a lot of weight, plus the fact of having four miscarriages which is in itself a breast cancer risk factor.
Ironically, my diagnosis snapped me out of my depression (or more likely, the healthy lifestyle I immediately adopted probably helped with that) and gave me the will to live that I had lost. I'm staying stress-free through trying to have hope that I will be a Mommy one day, staying on top of my work so I don't get stressed from that, exercising 5-6 days/week, getting enough sleep, getting sunshine exposure every day, and prayer and Bible study (this is extraordinary for keeping my stress levels down!). Like all of us, I'm hopeful that this stress-free life as well as everything else I'm doing health-wise will help prevent any recurrence and keep me healthy in other ways too.
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Hi,
I usually am on the Stage IV forum, but I very much follow this one too, and am grateful for the ideas presented here.
This article was on Medical News Today on 9/16/10. Since this topic is dealing with stress, I thought you might find it interesting. I posted it on the Stage IV forum as well.
Stress Significantly Acclerates Breast Cancer Metastasis In Mice, UCLA Cancer Researchers Show For The First Time
Chronic stress acts as a sort of fertilizer that feeds breast cancer progression, significantly accelerating the spread of disease in animal models, researchers at UCLA's Jonsson Comprehensive Cancer Center have found...
To read the full article, please go to:
http://www.medicalnewstoday.com/articles/201354.phpYou'll probably see me here more often!
Rachael
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Great article Rach958!
And no Barry...you're quite normal.
It's a no brainer, isn't it ladies. I mean what happens to us, let's say, if a loved one passes away...or our house burns down? I have no doubt that it would accelerate cancer cells. These are awful things...how does one suppress such sadness? Take deep breaths...and try to soldier on? It's hard.
As I said above...I'm a happy person...but when I hurt, I'm convinced it develops abnormal cells and those little buggers band together and turn nasty. When I had a fibrous cyst looked at, 6 years ago - my Breast surgeon said that I had abnormal cells around that area...the same area where l feel a stabbing pain when I'm upset. I don't think that it's a coincidence that I developed invasive breast cancer in the same spot 5 years later...especially after some of the trauma I went through. Funny thing, I didn't cry when I was diagnosed, and went through treatment. I've always been extremely positive and strong when it comes to my personal health issues. My house and garden are now jam packed with mighty forces of nature to take on this battle with the beast - that plus the fact that I'm pretty darn happy lately. My doctors tell me that I'm extremely healthy, and that my liver, kidneys, and uterus are in remarkable health, as is the rest of me. I have had just about every bloomin molecule in my body examined, for peace of mind and I'm going to give doctors/naturopaths a break for a while, and chill.
Great topic!
Hugs to all...xoxo
Victoria
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Hi Victoria and all, I agree about the stress triggering illness, most all of my health problems were triggered by stress related incidences. Ongoing duress, constant stress, emotional or physical stress also, can really tax the body enough to start a downward spiral of bad body functions, especially the immune system. Consider the adrenal blowout theory also, the triggering of over production of the adrenals which over produce estrogen type chemicals. It truly is a total body thing. No amount of food will do the trick if you have ongoing stress. The only way to address that is by facing what is going on and trying to change our stress addiction, and what is making our body deteriorate, which we all know is so many different emotional and physical issues.
For instance, I was a US rated volleyball player for years, I ran myself into the ground, a 'no pain no gain' type gal, who loved being exausted with fitness. What I didn't realize was that being out in the harsh sun, and pushing myself took it's toll eventually, having problems with EBV flare ups, [Mono, every time I got exausted] and strep throat often. I looked so fit, no one took it too seriously. But now I know, I should have listened to my body. It only works when you are young.
10 years later, I had melanoma twice, stage 2, now a 18 year survivor of that, no treatment, just lucky so far. How dumb was I to radiate my body in the hot sun during athletics for 20 years and not expect a breakdown of my health? As an athlete I was addicted to stress, I thrived on it, loved pushing myself, and now I realized how stupid that was. I asked too much of this body. Add emotional stress too! Duhhhh...
The Epstein Barr flare ups which were a form of horrible fluelike sore throats and colds, fatigue. Common with athletes who are run down. I ended up with a diagnosis of CFS ,chronic EBV, chronic fatigue syndrome, which I realize now is much more serious than I realized then. What I didn't realize then was that virus has been linked to some breast cancers and Hodgkens Lymphoma. So no surprise that I now have breast cancer and previous melanoma. I wasn't shocked at all.
After years of research trying to find answers to why I have all this, made me realize that yes, if you don't change the 'stressful life' then you won't get well. Finally I put away all the research, realizing that just reading about cancer caused me stress, and I had to take steps to not allow myself to be a sponge for stress, and especially with others. I had to change how I reacted to stress in my life, and let go of what I can't change, dump others stress, and find a way to find happiness. I did meditation, acupuncture, food changes, I based ALL my decisions on what is best for me, rather than everyone else in my life. I became active again, without pushing myself beyond exaustion. I got my life back for 10 years.
Last 2 years, surrmounting stress, parents ill, sister ill, exaustion again. People expecting too much of me. Bingo, I get breast cancer. I fully believe that we have to look at all stressors in our life before we can get a grip on all this. If we thrive on our stress and become addicted to our own adrenaline the CFS begins, a syndrome of exaustion. I even had to give up reading mystery novels! I kid you not, good stress does the same thing to the body as bad stress. We have to calm down the over production of hormones and brain chemicals. Thats a start.
I wish I had more answers but I don't. Distraction has been something I made myself get good at, to get the mind in a mellow state to block out stress, and that helps. I'm good at saying no to others now. It takes some work, like I became a wildlife photographer and hike by myself in the wilderness to free myself from urban stress. The peace that brings me has taught me alot. Dump the stress. It's bad, and I know, my first concern when facing this cancer was geez this is so stressful, how am I going to handle this now? Same thing, distraction, get as far away from it as possible. It really helps. I can even feel my adrenal glands calming down when I do my own form of meditation.
I have also not made any effort with past friends that were difficult friendships. My energy goes totally to myself now. I can't deal with making other peoples lives good for them anymore. They are on their own, and funny thing is, when you stop being their caretakers they don't need you anymore! OK, so needy people are off my list for now, lol. My husband dumps stress on me, I walk away, saying surely you can deal with that dear. ;~) He's learned I am no stomping ground anymore. This has found me some reserve energy. I don't know, I have two more chemos, then done with that. But the plan is to enjoy life fully when I recover. No more a dumping ground for others! Finding myself brings peace to me, which I believe helped me alot healthwise..
I know that sounded harsh, but thats about what I had to do to get my life back. I hope at least one person can relate and my comments help in some way.
Take care of yourselves, dear ladies! I wish you all the best. Get a T-shirt with a dump truck on it, and look at it every time you need to dump stress!
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I am convinced it is a combination of stress (with a little help from the BC pills of my youth) that gave me cancer.
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Linda, great post and very well said!
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Hi Soulswithin - I know what you mean.
My New Year's Resolution this year was applying the "I Don't Give a F*** Atitude" to many things...and spending little time as possible around toxic people. It's unhealthy. Unfortunately one of those people is a loved one...but the less I see of her the more peaceful my life is.
Victoria
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Ladies, I know Stress caused my BC. I had such a stressful upbringing (things I don't want to get into now) that when my sister and I wore dx with stage 3 and 4 BC I wasn't even surprised. I suffered for panic attacks most of my life. Its not what I eat that caused this, Its stress.
Betty
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Dear Everybody,
Sigh... haven't been here in quite a while. I believe stress can cause all sorts of things... Still healing from last surgery of Aug 08 - long story.
Has anyone else been angry or resentful at any point ...? I keep getting put in a position where I am needed to help. I can say no to friends, need new friends , any candidates here:) ?
I am overdue for testing and hoping all is o.k. but a but scared. Wasn't joking with Oncologist when I said hadn't had the luxury to deal with this. One day didn't know which emergency to deal with first...
My brother is in constant need of my help... No other family and so I get alot fallen into my lap. I have reached out for help but got nowhere. My brother was in a car accident and then had a stroke on one side... This happened almost 10 yrs ago. I wonder if anybody knows of any good caretaker forums.
Guess I am wondering who else here, am sure there is somebody, is in a similiar situation? I have gotten rude to my brother because I can't take anymore.
I try to eat well , exercise w/i what I can , my whole life has fallen apart and I would like life again...!!! I don't give up easily but things have been too hard for too long...
I reached out for some counseling and got nowhere. I finally found someone that I went to and he said I had too much going on. Well , thats why I came in thank you very much. A good understanding counselor would be worth their weight in gold right now. Many places didn't take my insurance . Perhaps I can try one more time , I actually called the local hospital cancer care and explained I was under enormous stress and really could use some support and asked for help in finding a counselor. Believe it or not didn't get anywhere. I guess I live in the wrong area . I live in M Wi if anybody knows anybody good?
Writing here is making me feel better. thanks for listening... I know I need more fun. Feel stuck in so many directions... Still hurt from a car accident that I was in - I was supposed to have surgery to fix it in feb 08 but couldn't because I found a lump... Still waiting to be o.k.
Any thoughts? What do you do to relieve stress? What do you do with family members that seem to pull on you beyond your capacity - Please don't say to take care of yourself first - trying to do that - but what do you do if that family member gets into a life/death situation?Literally , I pulled away and next thing he was in the hospital on a respirator and almost died...
Also been doing alot of helping save animals lives lately - will pull back from that.
Well, this is long , thanks for listening. Would love some new friends that are kind and supportive. Thats who I am usually. I am spiritually oriented .Writing this has been catharative and I see in writing what I don't want .
(((Hugs )))
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I know that stress played a role in the development of my cancer. I worked a really stressful job in my 20s, followed by marriage and the birth of my first baby at 32. I started suffering massive panic attacks after his birth, and seemed to have developed a generalized anxiety disorder. I had a miscarriage and lost another baby at 17 weeks, followed by two more births. I still had a lot of anxiety throughout that period.
I've really been working on the anxiety, with the help of some close friends and A LOT of exercise. I work out every day, and really feel it if I don't do it. My friends, who I've grown a lot closer to through this ordeal, have been a real source of support and love for me. I have realized that I had become isolated from girlfriends throughout the early part of my marriage and through the births of my children. I think social support, whether it's from family or friends (my family all live in seperate cities) is VERY important in dealing with stress.
My new motto is to try something every day that makes me ever so slightly uncomfortable or that downright scares me. I used to be a fearless woman, and somewhere along the way, I lost that ability.... so I am reclaiming it now, in hopes that it helps me fight off recurrance.
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P.S. Asshercut-- love your new motto!
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"A remembered stress, which is only a wisp of thought, releases the same flood of destructive hormones as the stress itself." - Deepak Chopra
Victoria
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Stress is Hurtful
http://www.psychologytoday.com/articles/199601/stress-its-worse-you-think?page=2
(exert from website ... understanding stress)
stress has a central command post, it is the hypothalamus, a primitive area of the brain located near where the spine runs into the skull. By way of a dazzling array of hormonal signals, the hypothalamus is closely connected with the nearby pituitary gland and the distant adrenal glands, perched atop the kidneys. The so-called hypothalamicpituitary axis (HPA) has a virtual monopoly on basic body functions. It regulates blood pressure, heart rate, body temperature, sleep patterns, hunger and thirst, and reproductive functions, among many other activities.
Like a cherry attached by its stem, the pituitary gland hangs off the hypothalamus waiting to receive instructions on which of its many hormones to release and in what quantity. In hormonal terms it is the little gland that could. The pituitary releases substances that regulate growth, sex, skin color, bone length, and muscle strength. It also releases adrenocorticotropin, a hormone that activates the third part of the body's stress system, the adrenal glands
When stress sets off the usual ferocious communication between the hypothalamus and the pituitary, the buck stops at the adrenal glands. They manufacture and release the true stress hormones-dopamine, epinephrine (also known as adrenaline), norepinephrine (noradrenaline), and especially cortisol. So responsive to the adrenal hormones are basic body functions like blood flow and breathing that even minute changes in levels of these substances can significantly affect health.
Slight overproduction of dopamine can constrict blood vessels and raise blood pressure; a shift in epinephrine could precipitate diabetes, or asthma, by constricting tiny airways in the lungs. If the adrenal gland slacks off on cortisol production the result may be obesity, heart disease, or osteoporosis; too much of the hormone can cause women to take on masculine traits like hair growth and muscle development and lead to one of the greatest fears of all for aging men-baldness. High levels of cortisol also may kill off brain cells crucial for memory.
Sensing impending danger the hypothalamus presses out cortisol-releasing factor, a hormone that prompts the pituitary gland to release adrenocorticotropin (ACTH). Carried in the bloodstream to the adrenal glands, ACTH triggers production of cortisol and epinephrine. The end result of this hormonal relay is a sudden surge in blood sugar, heart rate, and blood pressure-everything the body needs to flee or confront the imminent danger.
"These hormones are carefully regulated substances that direct everything from the immune system to the cardiovascular system to our behavioral system."
For example, cortisol directly impacts storage of short-term memory in the hippocampus. The stress hormones dopamine and epinephrine are also neurotransmitters widely active in enabling communication among brain cells. Directly and indirectly, they act on numerous neural networks in the brain and throw off levels of other neurotransmitters. Stress, it's now known, alters serotonin pathways. And through effects on serotonin, stress is now linked with depression on one hand, aggression on the other.
A torrent of studies catalogue how even a little stress can have wide-ranging effects on the body. Researchers have found that:
- Epinephrine, released by the adrenal glands in response to stress, instigates potentially damaging changes in blood cells. Epinephrine triggers blood platelets, the cells responsible for repairing blood vessels, to secrete large quantities of a substance called ATP. In large amounts, ATP can trigger a heart attack or stroke by causing blood vessels to rapidly narrow, thus cutting off blood flow, says Thomas Pickering, M.D., a cardiologist at the New York Hospital-Cornell Medical Center.
- Other substances released in the stress response impair the body's ability to fight infections. In one study, researchers tracked the neurohormones of parachute jumpers. They found an 84 percent surge in nerve growth factor (NGF) among young Italian soldiers attempting their first jump, compared with nonjumpers. Up to six hours after they hit ground, the jumpers' NGF levels were 107 percent higher than in nonjumping soldiers. Released by the pituitary gland as part of the stress response, NGF is attracted like a magnet to disease-fighting cells, where it hinders their ability to ward off infections. An immune system thus suppressed can raise susceptibility to colds-or raise the risk of cancer.
- Cortisol activation can similarly damage the immune system. Sheldon Cohen, Ph.D., professor of psychology at Carnegie Mellon University, gave 400 people a questionnaire designed to quantify the amount of stress they were under. He then exposed them to nose drops containing cold viruses. About 90 percent of the stressed subjects (versus 74 percent of those not under stress) caught a cold. He found they had elevated levels of corticotrophin-releasing factor (CRF). "We know that CRF interferes with the immune system," Cohen says. "That is likely the physical explanation why people under stress are more likely to catch a cold."
- Stress hormones are also implicated in rheumatoid arthritis. The hormone prolactin, released by the pituitary gland in response to stress, triggers cells that cause swelling in joints. In a study of 100 people with rheumatoid arthritis, Kathleen S. Matt, Ph.D., and colleagues at Arizona State University found that levels of prolactin were twice as high among those reporting high degrees of interpersonal stress than among those not stressed. Other studies have shown that prolactin migrates to joints, where it initiates a cascade of events leading to swelling, pain, tenderness. "This is clearly what people mean when they say stress is worsening their arthritis," Matt says. "Here we have the hormone released during stress implicated in the very thing that causes arthritis pain, swollen joints."
- After being released by the pituitary gland, the stress hormone ACTH can impede production of the body's natural pain relievers, endorphins, leading to a general feeling of discomfort and heightened pain after injury. High levels of ACTH also trigger excess serotonin, now linked to bursts of violent behavior.
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A really lovely Asian woman with whom I've had business dealings...and have developed a nice friendship with was also going through rads with me. (small world) She's been living in Australia for about 8 years now. She was not doing well at all with treatments. Her family had come to Australia to take her back to Hong Kong to have treatments with Chinese herbalists, as she had done all her life - they felt Western medicine was killing her. I asked her what she was going to do in early 2010 and she said her businesses are doing well and that being triple positive she needed Herceptin and it was free in Australia...so she would stay. Later on in the year she wasn't doing well, she had lost a lot of weight and wasn't looking healthy at all. Unfortunately she is in an abusive marriage...and has been terribly unhappy on the home front for as long as I've known her. I never once saw her husband during treatment...it was always her sister by her side. A couple of months ago she decided to go to China for treatment...her husband remained in Australia.
Perhaps treatment with a Chinese herbalist may suit her DNA...more than Western medicine.
And then again...if she doesn't address the stresses she is facing at home with her abusive husband...doesn't matter what treatments she is undergoing whether it is Western or traditional Chinese...she may never quite recover.
Don't know...but I wish her all the best...x
Victoria
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You say ACTH triggers production of cortisol BUT this is inhibited by MELATONIN.
Search pubmed for MELATONIN EXERTS DIRECT INHIBITORY ACTION ON ACTH Responses on Human Adrenal Gland.
Improving quality of sleep by paying attention to sleep hygiene,Getting BRIGHT LIGHT exposure through the day (ideally outdoors for 4hrs to reset circadian rhythm but improved bright light (4000lux) at workplace also helps) using subdued lighting in the evening (the freely downloadble FLUX software program automatically dims your PC monitor after dusk) and keeping your bedroom as dark as possible (or wear and eye mask) all help improve natural melatonin secretion. Time Release Melatonin supplements are an option if improving natural melatonin secretion doesn't allow you to fall asleep and stay asleep as long as you need. UK readers will need to import from the discount stores in the USA.
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Ted, thanks for posting. I've definitely noticed that my sleep in impacted by light. When I'm on the computer at night, I have problems falling asleep (even though I was just sitting there, not doing anything).
BTW, the whole concept that stress can lead to cancer is...super stressful! How can I stop that? But I do wonder. I've heard that that treatment outcomes improve when done in conjuction with mind-body complementary treatments (guided imagery, healing touch, meditation). I wonder if the calming (de-stressing) influence is the key?
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My gut feeling tells me that stress is definitely a factor in geting cancer. I was experiencing a lot of stress the year before I was diagnosed and I have known several others who have been diagnosed after divorces. But people like my mother-in-law make me wonder. She has always been an extremely anxious, high-strung worry-wart. She worries and cries and doesn't sleep. She has always been a hypochondriac and constantly thinks that she has cancer. Everyone shields her from any bad news because she always seems stressed out (e.g. I haven't told her about my bc). She never exercises, but does eat well. Well, now she is 90 and in perfect health. No cancer, no diabetes, no heart problems, nothing at all. I, on the other hand, believe in being stoic and handling my own problems as well as a lot of other people's. I also exercise regularly. I have breast cancer and high blood pressure. Hmmmm. My mother-in-law always seems stressed and worried, and yet is in perfect health. Is there a lesson here?
Diagnosis: 8/18/2010, IDC, 1cm, Stage I, Grade 2, 0/2 nodes, ER+/PR+, HER2- -
@ peggy_j
You may find it helpful to download the FREE FLUX program that automatically ajusts the brightness of your PC monitor. It tracks the time of dusk/dawn whereever you live and dims/brightens your screen so it's appropriate for night/daytime use. I find it very helpful as I forget what the time is when I'm online.
I'm sure every approach that reduces stress will be helpful. However I think we need to remember that cortisol is INFLAMMATORY and most adults tend to have very low anti inflammatory reserves. So improving our natural antiinflammatory status is the key to being better able to cope with the inevitable stresses living in the real world creates
. I started learning about the way omega 3 fatty acids resolve inflammation, I then realized that omega 3 deficiency was only one part of the problem and really we need to reduce omega 6 (pro inflammatory) consumption in order to allow omega 3 the space to work. Vitamin D3 was my next breakthrough and correcting vitamin D3 status with 5000iu/daily/D3 made a big difference, But that lead to the knowledge that as vitamin d raised calcium absorption I also needed to counterbalance that with more magnesium (plenty of calcium in diet and water but insufficient magnesium). But while our bodies are meant to create the anti-inflammatory, anti-oxidant vitamin D3 through the day, during the evening and at night they are supposed to secrete the anti-inflammatory anti-oxidant melatonin. In paleo times it would have been a continuous process bright light in the moring stopping melatonin secretion and starting D3 production and the reverse at dusk with melatonin secretion taking over when D3 production via UVB exposure ceases.
. There are also the anti oxidants curcumin (curry) and resveratrol (red wine) that come into the story. So it's a complicated story but I think there is much we can do to improve the anti inflammatory anti oxidant side of the story so when stress hits (and we can never be sure what will happen in the future) we are better able to deal with the inflammation that the raised cortisol creates.
I don't believe that restoring the NATURAL levels of anti inflammatory reserves human DNA evolved to function best with presents any conflict with other treatment regimes. In the same way we would not expect people with food/water deficiency to recover well, so being deficient in the micronutrients omega 3, vitamin d, melatonin, magnesium are bound to impact adversely on the outcomes of whatever therapy you opt for.
PS Once again a post of mine has been reported as spam. Everyone with BC must be aware that having BC is not a matter of concern ONLY for the women directly involved. Husbands, partners, male friends all suffer grief at the loss of loved ones and share the stress that those being treated for the cancer suffer. Recently a dear friend of mine was diagnosed and the treatment wasn't successful. The stress of the diagnosis and treatment led to her mother having a stroke and as a direct result developed Alzheimer's, The mother died weeks after the daughters funeral, the husband commited suicide a few months later.
We all need to understand better how our bodies/minds deal with stress and understanding how Cortisol causes inflammation and how our body's are currently deficient in the anti-inflammatory resources required to resolve that inflammation is fundamental to being able to deal with stress.
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