IP6 as a treatment for breast cancer

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Anyone have any knowledge or experiece with this? Thanks for all replies.

 http://www.naturalnews.com/024635_IP6_cancer_cancer_cells.html

(NaturalNews) The anticancer effects of IP6 are turning out to be nothing short of astounding. Research is showing that besides reducing cell proliferation and increasing the differentiation of malignant cells, IP6 can often restore cancerous cells to normality.

What is IP6?

IP6, also known as inositol hexophosphate or phytic acid, is a sugar molecule with six phosphate groups attached. It is composed of inositol (one of the B vitamins) bound with six molecules of phosphorous. IP6 was first identified in 1855, but has only recently been researched as a preventative and cure for cancer as well as heart and liver diseases, kidney stones, Parkinson's disease, and more. It is also a powerful antioxidant, immune system enhancer, and booster of natural killer cells. Foods that are significant sources of IP6 include dried beans, whole grains, nuts, seeds, rice, wheat germ, corn and sesame.

Dr. Abulkalam Shamsuddin, a scientist at the University of Maryland School of medicine has been the pioneer researcher of IP6, beginning his work on the compound in the late 1980's. He discovered the ability of IP6 to control the rate of abnormal cell division even when administered long after cancer was induced. He then proved that IP6 normalized the sugar production of cancerous cells, thereby altering the gene expression toward a more healthful state. This proven ability to change cancer cell physiology had major implications, since cancer cells that are well behaved have far less negative impact on health.

Although IP6 has been proven to boost Natural Killer (NK) cell activity, for Shamsuddin the value of IP6 lies not in its ability to augment the immune system, but rather its ability to directly affect the physiology of cancerous cells. Whereas most cancer research has focused on killing or destroying cancer cells, Shamsuddin's research focused on taming or controlling the condition to the point where normality could be restored.

How IP6 works to Protect Against Cancer

Here are several ways IP6 is known to prevent and fight against cancer. IP6 is a very common intracellular messenger, meaning that it controls and influences many cellular activities:

Normalizes the Rate of Cell Growth - Cancer cells lose their control mechanisms and typically divide too rapidly, resulting in great numbers of cells that have a devastating impact on health. IP6 slows or normalizes the rate at which cancer cells divide. It reestablishes control in cells that by definition have lost their control mechanisms due to gene mutation.

Helps to normalize cell physiology - How a cancer cell expresses itself largely determines how threatening it is. Experiments have shown that IP6 normalizes several aspects of cell physiology in spite of the fact that these cells have altered DNA. In many instances, DNA repair is achieved.

Enhances NK cells - NK cells are white blood cells that help to protect against virally infected or cancerous cells. Researchers believe that the higher the NK activity, the lower the incidence of some cancers. The healthy human produces 500 to 1000 cancer cells daily. NK cells and programmed cell death (apoptosis) result in the vast majority of these cells being destroyed and removed. During time of stress, NK activity is compromised, and this is why there is a link between stress levels and cancer. IP6 is able to increase NK cells during these periods. Although many supplements claim to increase NK activity, for IP6 these claims have been documented and proven.

Increases tumor suppressor P53 gene activity - DNA contains tumor suppressor genes that inhibit pathways or processes that allow cells to become cancerous. The p53 gene acts as a control to preventing genetically damaged or cancerous cells from growing and propagating. If the p53 gene becomes damaged or compromised, cancers can establish themselves more readily. IP6 has been shown to greatly increase the amount of p53 gene activity, up to 17 times. When augmented by IP6, "standard of care" treatments become more effective due to this increase in p53 gene activity.

Inhibits inflammation - The level of systemic inflammation is an important indicator in determining cancer survival prognosis. Inflammation results in the release of cytokines, chemical messengers that trigger reactions that enable normal cells to grow and repair themselves. Cytokines can also cause cancer cells to grow. IP6 has been shown to significantly inhibit inflammation.

Exhibits potent antioxidant activity - Antioxidants are known to protect against various disease states and aging in general. Oxidative damage to DNA leaves cells susceptible to mutation that can result in cancerous cells being produced. IP6 has been shown to be a significantly more potent antioxidant than green tea.

Enhances apoptosis (programmed cell death) - Programmed cell death is orderly and results in the removal of individual cells without affecting the surrounding cells. It is a normal part of growth and the maintenance of healthy tissues. It removes unwanted cells so that inflammation or immunological reactions do not result. Cancerous cells are resistive to normal cell apoptosis. This is one mechanism of tumor formation. IP6 has been shown to enhance the natural apoptosis of cancer cells.

Affects angiogenesis - Angiogenesis is the process by which tumors set up their own blood supply, assuring the nutrients necessary to fuel their growth. Once this blood supply is set up, tumor growth spirals as more growth leads to more establishment of blood supply. IP6 inhibits this process, resulting in the starvation of cancer cells.

Inhibits metastasis - IP6 inhibits the adhesion of cancer cells to the extra-cellular matrix proteins, thereby leading to an inhibition of cell migration and invasion. Limiting adhesion is very important after surgeries and biopsies, as these procedures can cause cancer cells to become dislodged. One reason that so many breast cancer patients are found to have lymph nodes containing cancer cells is that mammography can dislodge cancer cells which then migrate to the lymph nodes.

Pharmaceutical research is geared to the development of drugs to treat cancer utilizing these mechanisms. Many of the substances being developed and tested are newly created molecules, having never before appeared in nature. As a result, severe side effects are common place. IP6 already exists in human cells and is easily recognized by the body, so side effects, if any, are rare.

Recent research findings document these mechanisms

The frequency and depth of research into IP6 is expanding at a rapid rate. Here are some of the most recent findings.

The Journal of Clinical Cancer Research, reports a study evaluation the in vivo cancer preventative efficacy of IP6 against prostate tumor growth and progression. Prostate cancer was induced in male mice that were then given either water containing IP6 or plain water. IP6 inhibited prostate cancer progression at the neoplasia state and strongly reduced the incidence of adenocarginoma. The incidence of well-differentiated and poorly differentiated adenocarcinomas in the IP6-fed group were reduced by 44% and 62% respectively. Analysis of the prostate tissue showed a 3.5-fold increase in apoptotic cells. The researchers concluded that these findings are highly significant in establishing for the first time that oral IP6, without toxicity, suppresses prostate tumor growth and progression at the neoplastic state, the state of abnormal or uncontrolled growth.

A study conducted in China and reported in Wei Sheng Yan Jiu explored the effect and mechanism of IP6 on cell proliferation in human gastric carcinoma. They found that IP6 inhibited malignant cell growth in a dose and time dependent manner. The proliferation of gastric carcinoma cells inhibited by IP6 was associated with apoptosis through altered gene expression.

The Brazilian journal, Acta Cirurgica Brasilerira reported a study to determine the modulation effect of IP6 in the biological immunohistochemistry expression of cellular signaling marker apoptosis in a model of induced colon cancer. They found that IP6 was effective in promoting modulation of biological markers in colon cancer.

Another study reported in Acta Cirurgica Brasilerira analyzed of the influence of IP6 on the transcription of genes coding for tumor necrosis factor-alpha and its receptors in a human colon cancer cell line. The results showed that IP6 modulated the expression of the listed genes at transcription level in a dose and time dependent manner.

The journal Neurochemistry Research reported a study of the impact of IP6 as a therapeutic agent on glioblastoma, the deadliest brain tumor in humans and the one currently being battled by Senator Kennedy. Researchers found that the viability of glioblastoma cells decreased following treatment with increasing doses of IP6. The treated cells showed morphological and biochemical features of apoptosis.

Laryngoscope reports a study that found IP6 effective at promoting nuclear factor-kappa B, an early response gene that is associated with head and neck squamous cell cancer. This increased gene expression resulted in reduced cell proliferation and increased cell death.

IP6 is more than a cancer treatment

In addition to the anti-cancer benefits of IP6, ongoing research is revealing its promise as a treatment for diabetes, depression, osteoporosis, heart disease, and kidney stones.

A very recent study reported in the Journal of Toxicology considered the effect of IP6 on Parkinson's Disease. Disrupted iron metabolism and excess iron accumulation has been reported in the brains of Parkinson's patients. Because excessive iron can induce oxidative stress and result in neuronal degradation in Parkinson patients, researchers sought to determine the protective effect of IP6, a natural chelator of iron. They found a 45% reduction in DNA fragmentation with the use of IP6, and protection in the differentiated cells. They concluded that IP6 offered a significant neuro-protective effect.

Supplementing with IP6

IP6 has been shown to be quite safe to use. It is naturally present in mammalian cells, and it is obtainable from food. However, in food, IP6 is bound to protein. Before it can be absorbed it must be freed from this protein. An enzyme called phytase that is present in both food and the intestinal tract performs this function. The problem is that the power of the phytase enzyme is damaging to the IP6 and renders much of it inactive and therefore less effective. Pure IP6 from a supplement is not protein-bound and is easily absorbed in tact, and able to provide its complete medicinal properties. Research has shown that when fiber from All Bran was added to the diet of rats with mammary cancer it was much less effective than the equivalent amount of IP6 added to their drinking water.

Many holistic healers and naturopaths recommend IP6 as both a preventative and treatment for cancer. It is becoming standard alternative treatment to recommend it for anyone with a high risk of cancer or who has had cancer and is looking to prevent a recurrence. Some traditional physicians are also becoming aware of the potential of this compound and although they are loath to abandon their traditional treatments, they are adding IP6 to their protocols.

IP6 is available in capsules or powered form. The capsules provide what is considered to be a maintenance or preventive dose of 2 capsules twice a day. The powered form allows for easy dosing at the therapeutic level which is one scoop mixed with water twice a day. IP6 should be taken on an empty stomach. IP6+Inositol from Cell Forte is the most economical and readily available brand. It is sold online at Vitacost.

Sources:

"Complementary Therapies", University of Texas MD Anderson Cancer Center.

Dr. Kim Vanderlinden, Dr. Ivana Vucenik, Too Good to be True?
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Comments

  • Zara79
    Zara79 Member Posts: 5
    edited January 2010

    bump, added detail

  • luv_gardening
    luv_gardening Member Posts: 1,393
    edited January 2010

    Do you have breast cancer Zara, or personally care for someone who does?  This is your first post after joining today and looks suspiciously like advertising so I guess I should report it but I'll give you the opportunity to delete it and introduce yourself first if you indeed do have breast cancer.

    ~~~~~~~~~~~

    Edited to apologise for suggesting this was anything but genuine. I have heard good things about IP6 but have been bugged on other sites and by people who think they have "the" answer, also by oncologists who told me they know everything about cancer but none of them have any idea what it's like to have cancer themselves.  

    Just having a bad hair day I guess. (What hair?)

    See my later posts.

  • carol1949
    carol1949 Member Posts: 562
    edited January 2010

    I go to an accupuncture physician who also does Reiki and she gave me information on this as well.  My accupuncture physician doesn't sell it, but thought it was valuable information.

    I believe it is on the correct site of alternative therapies.

      I also learned about an herb called ashwaghanda (sp?) and was a bit concerned if I should be taking it, so did some research and found that Sloan Kettering says it is valuable in cancer tx.

    I am hearing of more and more MD's turning to some Eastern medicines and or treatments.

    Let's see if anyone else is informed regarding this.  I would be very interested to hear.

    I have gone totally holistic post traditional therapy and for me, I can only tell you, that I feel it was the right thing to do.

    p.s.  There is also a new book out by Donna Deegan who is a news anchor in Jacksonville, FL and a 3 time b/c survivor.  Most recently after her lung mets.... the Dr. who is treating the lung part encouraged her to go holistic as a complimentary therapy!  You can Google her and check her out.  Her new book is Through Rose Colored Glasses and I believe most if not all of the money goes to bc research at Mayo and/or her foundation to help women in need in the Jax area.

    Lets keep our minds open!  No one has to buy  anything if they don't want to .

  • Zara79
    Zara79 Member Posts: 5
    edited January 2010

    No Sheila, I don't have breast cancer.  Someone I know does, just had a double masectomy and cancer cells have been found in nodes.  I am interested in learning about alternate treatments to chemotherapy that are based on sound science (whether or not such science is suppported by the pharma/medical establishment). 

    I will not delete the OP as it doesnt advocate for a specific product from a specific company (that I know of) and therefore does not constitute advertising.  You can if you have the capability but that would render this board as far from objective.

  • luv_gardening
    luv_gardening Member Posts: 1,393
    edited January 2010

    No offence meant Zara, it's just that this sounds so much like many of the "cure cancer" ads that come up all the time so I wanted to challenge you to see if you were legitimate.  Are there any actual studies you can point us to rather than articles?

  • luv_gardening
    luv_gardening Member Posts: 1,393
    edited January 2010

    Zara, If you've just started searching here are some comprehensive sites in case you haven't found them yet which look at many alternative methods.

    http://alternativecancer.us/#Chemo

    http://www.cancerfightingstrategies.com/index.html

    http://cancertutor.com/index.html

    http://www.beating-cancer-gently.com/aboutme.html

     A book called Anti-Cancer, by David Servan-Schreiber, MD, PhD, a Dr who overcame brain cancer is essential reading, and I have found "Definitive Guide to Cancer" by Lise Alschuler,ND and Karolyn A. Gazella to be an excellent reference. I always get books from the library before deciding whether to spend money on my own copy.

     Also see threads on this CAM forum for iodine, CoQ10 and DIM which are more specifically for breast cancer.  I'm sure there is more but I'm burnt out at the moment from too much research and the constant juicing and preparing of foods, weeding the veggie garden, exercising, trying to get early nights for natural melatonin production, dealing with the almost bald head and hollow chest while also dealing with mine and other people's anxiety about this illness.  Plus the usual life concerns about family, money etc.

     I did the same as you when some of my relatives got cancer many years ago. They were not open to alternative suggestions but I felt I needed to be educated in case I ever had a diagnosis as I knew it would be hard doing the research at the same time as making important treatment decisions.

    The problem is that very little alternative research is done that is acceptable to the medical establishment as it would require patients to take the alternative therapies thereby not taking chemo, radiation etc. otherwise there is no way to know what worked, the conventional treatment or the alternative.

    I guess this means that the pharmaceutical companies have a hold on cancer treatments like a bulldog that is hard to break. One daren't break away from the "established standard of care", even if almost eveyone that dies of cancer has used that so called standard and it's failed them.  Mammograms and ultasounds failed to show even a hint of my 4cm tumour and the Dr assured me it didn't feel like cancer but fortunately he referred me to a BS for a biopsy.  After the diagnosis the tumour failed to show up on a CT scan which showed oedema at the site. So how am I supposed to know if it's spread?

    So after all my pre-cancer research, when I got the diagnosis myself the research did help but didn't prepare me in any way for the sheer brutality of the diagnosis and the effect on my life.  Nor was I prepared for the fact that there is no way to monitor any alternative treatments or to know if the cancer may return after 6 months, a year, 2, 5, 8, 10, 15, 20, I've seen 22 years on this board with the same cancer returning.  So while I'm waiting to see if this thing returns I have no way of knowing whether I'm taking enough CoQ10 or other foods and supplements, or if they are doing any good at all.  We are never free of the fear.  So I'm stuck with forever watching what I eat, drink, think, how I sleep and constantly researching since I can't trust the professionals to do anything that is not endorsed by the pharmaceutical companies. 

    I had a double mastectomy and 9 nodes affected so I know what's ahead for your friend.

    So please forgive me if I'm a little cranky.   I do wish you luck with your friend and we sure can do with friends who are open to alternative therapies so thank you for being there for her. 

  • carol1949
    carol1949 Member Posts: 562
    edited January 2010

    From what I can find, Sloan Kettering has some information on it as well.  They do say thay so far ( as of 2009, when their article was posted) there had not been human studies, but in vitro and animal studies were promising.

    It really is just a compound of inositol and I believe, calcium,  and magnesium  , so certainly shouldn't upset anyone!  I just did another Google on it and found it on one of the popular vitamin websites for around $15. 

    Inositol is good for you hair if nothing more!  Certainly, we are losing far too many of our bc sisters who are doing only traditional therapies. I think we have to be our own advocates and find out what more is available to us.

      I have a dear friend who is an 11 year bc survivor who did it holistically.  She went through the Cancer Treatment Centers of America and had surgery and even though they wanted to do chemo and rads, she refused.  Instead of sending her away, they armed her with alternative therapies, such as nutritional approaches, Reiki, etc.  She has shared with my much of the things she used over the years and nothing seemed really quacky to me.  Having said that.... you can say quack all day long to me, but 11 years cancer free speaks to my heart!

    Please, let's continue to share.  No one is forcing anyone to do anything they don't want to do!

    p.s.  My oncologist told me that to do research on Femara was going to be discouraging, since it was still too new to have much valuable data.  Remember it takes years to do the study and then it has to be published!

  • carol1949
    carol1949 Member Posts: 562
    edited January 2010

    Sheila, I am sending you pleasant thoughts and gentle hugs.

     I also read the anti cancer book which you mention and another lady on this board says it was suggested to her at the Boston, treatment center where she goes.

    Another book that I found very helpful was You Can Heal Your Life, by Louise Hay.  It is also available in a movie form, though I have not seen the movie.  Louise Hay has been featured on Oprah and many seminars.  I normally tell people, I I didn't read that book, I wouldn't be here!  

    I am a firm believer that any "dis" ease is body, mind and spirit.  Our bodies want to be healthy.  when we are at "dis" ease, our bodies can allow unhealthy things to manifest.

    Find whatever speaks to your heart and know that you are worthy to be healed and it IS possible!

  • luv_gardening
    luv_gardening Member Posts: 1,393
    edited January 2010

    Off Topic. Apologies to the OP.

    Thanks Carol though I don't like myself much after being so reactive and protective of this forum at someone else's expense.  I need to think about my belief system which is not helpful to my mental welfare as I believe our actions and thoughts contribute to our mental and physical health.

    I have the recent version of the Louise Hay book which I find very soothing just to pick up and leaf through.  The artistic work is like nothing I have seen in any book. I can see how the book would inspire people to feel better despite their situation. I've always cringed at affirmations and find they don't work if they are too far from how I'm feeling so I look for healing words which I can find believable rather than those that make me want to protest.  I've followed Esther Hicks for around 8 years and went to a workshop here in Sydney, Australia 2 months ago and I try hard to use the Abraham material. That means accepting where I am and trying to look for better feeling thoughts.  

    I'm afraid part of my negative frame of mind is due to my mother who is getting dementia but is in denial and doesn't realise she is not taking her medications or evening insulin or paying all her bills. Her life is in danger and I know she will not be around for long but there's little I can do about it and feel so helpless. I might start a separate thread about this. There must be a forum somewhere where people can vent about other issues as our mental health is surely important to our welfare.

  • carol1949
    carol1949 Member Posts: 562
    edited January 2010

    Sheila, I am also familiar with the Hicks.  All good material.  You have to do whatever makes sense to you .  For everyone that may be different and that is OK.  At least you are doing something!

    You are right, it is body, mind and spirit.  The breasts represent nurturing and as women, so many of us tend to put ourselves last which can lead to allowing "dis" ease to manifest.

    One of the things my Reiki lady says to me w/ each therapy and I find so helpful, is" Release all of the old thoughts and feelings..... they no longer serve you"  For me, it allows for much peace.

    Hugs sent your way!

    Carol

  • Husband11
    Husband11 Member Posts: 2,264
    edited January 2010

    Here is some research on various breast cancer cell lines treated with IP6

    Inositol hexaphosphate (IP6) enhances the anti-proliferative effects of adriamycin and tamoxifen in breast cancer.
    Tantivejkul K, Vucenik I, Eiseman J, Shamsuddin AM.

    Department of Pathology, University of Maryland School of Medicine, Baltimore, MD 21201, USA.

    The current treatment of breast carcinomas recognizes the importance of combination therapy in order to increase efficacy and decrease side effects of conventional chemotherapy. Inositol hexaphosphate (IP6), a naturally occurring polyphosphorylated carbohydrate, has shown a significant anti-cancer effect in various in vivo and in vitro models, including breast cancer. In this study, we investigated the in vitro growth inhibitory activity of IP6 in combination with adriamycin or tamoxifen, against three human breast cancer cell lines: estrogen receptor (ER) alpha-positive MCF-7, ER alpha-negative MDA-MB 231 and adriamycin-resistant MCF-7 (MCF-7/Adr) using the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay. Much lower concentrations of IP6 were required after 96 h of treatment to inhibit the growth of MCF-7/Adr cells than MCF-7 cells; the IC50 for MCF-7/Adr cells was 1.26 mM compared to 4.18 mM for MCF-7 cells. The ER-negative MDA-MB 231 cells were also highly sensitive to IP6 with IC50 being 1.32 mM. To determine the effects of IP6 in combination with either adriamycin or tamoxifen, the median effect principle and Webb's fraction method were used to determine the combination index (CI) and the statistical differences. Growth suppression was markedly increased when IP6 was administered prior to the addition of adriamycin, especially against MCF-7 cells (CI = 0.175 and p < 0.0001). Synergism was also observed when IP6 was administered after tamoxifen in all three cell lines studied (CI = 0.343, 0.701 and 0.819; p < 0.0001, p = 0.0003 and 0.0241 for MCF-7/Adr, MCF-7 and MDA-MB 231, respectively). The growth of primary culture of breast cancer cells from patients was inhibited by IP6 with LC50 values ranging from 0.91 to 5.75 mM (n = 10). Our data not only confirm that IP6 alone inhibits the growth of breast cancer cells; but it also acts synergistically with adriamycin or tamoxifen, being particularly effective against ER alpha-negative cells and adriamycin-resistant cell lines.

    PMID: 12846414 [PubMed - indexed for MEDLINE]

    http://www.ncbi.nlm.nih.gov/pubmed/12846414?ordinalpos=1&itool=EntrezSystem2.PEntrez.Pubmed.Pubmed_ResultsPanel.Pubmed_SingleItemSupl.Pubmed_Discovery_RA&linkpos=3&log$=relatedarticles&logdbfrom=pubmed

  • Husband11
    Husband11 Member Posts: 2,264
    edited January 2010

    Here is a detailed article from the Journal of Nutrition:

    http://jn.nutrition.org/cgi/content/full/133/11/3778S

  • vivre
    vivre Member Posts: 2,167
    edited January 2010

    That was very well said Sheila. I wish you would join us on the natural girls thread. You will fit right in. You too Carol and Timothy. You guys do great research.

    And Sheila, I know that all this is still very exhausting and you are so tired of all the research, but I can tell you that as you get well, and start to feel so healthy from all the lifestlye changes you have made, you will feel so empowered. You will not fear a recurrance and it will not rule your life. I hope you keep up going in this direction. I no longer feel I just survived cancer. I feel like I am thriving more than I did before bc. It takes time, but time does heal all wounds. I would love to see some of you come to my prevention convention in Chicago in March. Keep checking out the natural girls thread, or PM me your email and I will send you the details.

    Zara-thanks for posting this. I know a lot of people around here think Mike Adams is a quack, but he works hard to get the information out there that our doctors ignore. We need to have all the puzzle pieces or we will never be able to put ourselves back together again.

  • Yazmin
    Yazmin Member Posts: 840
    edited January 2010

    SheilaEchidna, you wrote:

    "...One daren't break away from the "established standard of care", even if almost eveyone that dies of cancer has used that so called standard and it's failed them.  Mammograms and ultasounds failed to show even a hint of my 4cm tumour and the Dr assured me it didn't feel like cancer but fortunately he referred me to a BS for a biopsy.  After the diagnosis the tumour failed to show up on a CT scan which showed oedema at the site. So how am I supposed to know if it's spread?..."

    Your story sounds so much like mine, and so much like the story of thousands of other women facing down cancer. I am not surprised that your 4cm tumor was never seen coming: neither was my 3cm one, despite 10 years of dutifully enduring mammography every single year.

    It is so sad that Research remains confined to the "same old, same old, same old" despite the fact that you are pointing to: that most of the people treated the conventional way will eventually die of cancer. But the medical establishment won't change anything. They won't go out the beaten paths and look in another, innovative direction. Fran Visco, President, National Breast Cancer Coalition Fund, did write: "...exciting research does not pay". No, it doesn't.

  • Zara79
    Zara79 Member Posts: 5
    edited January 2010

    Thanks for all the responses.  Timothy that's some really interesting information.  Sheila, no worries.  I wasn't offended.  I found a video of a physician discussing homeopathic treatments including IP6

    http://www.youtube.com/watch?v=wio5nBPhePY

  • thenewme
    thenewme Member Posts: 1,611
    edited January 2010

    Hi Zara,

    There have been several discussions regarding the accuracy/reliability of NaturalNews as a resource, so it's usually best to check multiple sources for anything you read there or elsewhere (especially if the information is coming from a site that sells supplements).  It seems that IP6 is very promising, but at the moment it hasn't been successfully tested in humans, so it seems a bit premature and sensationalistic to say the anticancer effects of IP6 are "nothing short of astounding."

    Sloan Kettering has this to say about IP6:

    To prevent and treat cancer
    Laboratory studies show that inositol hexaphosphate slows the replication of isolated cancer cells, but there is no proof from clinical trials that this effect occurs in humans. 

    The MD Anderson site itself seems to have a much more conservative writeup than NN:

    IP-6

    Background and Health Claims
    IP-6, also known as inositol hexophosphate or phytic acid, is a sugar molecule with six phosphate groups attached. Naturally present in whole grains and high fiber foods, IP-6 recently has gained popularity as a cancer fighter. Experts feel that it also may play a role in the prevention and treatment of heart disease, kidney stones and liver disease.

    At this time, the exact mechanism through which IP-6 works is not known. It may decrease the proliferation of cancer cells, act as an antioxidant, enhance the immune system by boosting the activity of natural killer cells (which destroy abnormal cells), or influence cells' ability to dedicate themselves to a particular function.

    Much of the scientific research completed with IP-6 has been done by Abulkalam Shamsuddin, a scientist at the University of Maryland School of Medicine. Several of Dr. Shamsuddin's animal and human cancer cell line studies have shown promising results with colon, prostate, liver and breast cancer. Epidemiological studies show that people who eat lots of foods that contain IP-6 have lower incidences of cancer of the breast, colon and prostate. Foods that are significant sources of IP-6 include soybeans, rice, sesame, beans, legumes, corn and cereals.

    Precautions
    IP-6 reduces platelet activity; therefore, people with low blood cell counts, or who are taking aspirin or other blood thinning medications, may want to avoid using IP-6. Because of its antioxidant properties, IP-6 may not be appropriate for patients receiving radiation or chemotherapy. Supplemental forms of IP-6 may also bind with calcium, magnesium, copper, iron and zinc and should therefore not be taken with food.

    Dose
    Although Dr. Shamsuddin indicates that further research must be completed before making more specific dosage recommendations, he gives the following guidelines: 1-2 g of IP-6 daily for cancer prevention, 4 g daily for people with an increased cancer risk, and up to 8 g daily for those with cancer. Patients who are considering an IP-6 supplement should consult with their physician or dietician.

    Obtaining IP-6 from natural food sources is likely very safe. The following table shows the amount of IP-6 in various foods.

  • orange1
    orange1 Member Posts: 930
    edited January 2010

    Most people treated with conventional methods will not eventually die of breast cancer.  In the US there are approximately 200,000 new cases of BC each year and about 40,000/year die.  So about 1 in 5 dies.  This includes people who are diagnosed with Stage IV at the onset.

  • luv_gardening
    luv_gardening Member Posts: 1,393
    edited January 2010

    Orange, if you're referring to my comment, you've misread it:

    "One daren't break away from the "established standard of care", even if almost everyone that dies of cancer has used that so called standard and it's failed them. "

    Probably 99% or more who die from breast cancer have been through the standard treatment.  Of course that doesn't mean that most people diagnosed with BC will die.  Your USA figures of 1 in 5 are the same here in Australia, less cases but same ratio. It's the actual stage (not the artificial diagnostic stage) when treatment starts and the aggressiveness of the cancer that decides the outcome. And of course the primary tumour needs to be dealt with or it will inevitably proceed to end stage disease.

    I suspect there is a "point of no return" where the primary cancer sets up some way of reproducing itself independently of the primary tumour.  Once that point has come, surgery, chemo and other treatments may kill tumours, shrink or slow them down but unless the means of distant reproduction (such as stem cells) are killed or disarmed then it will come back. 

    I hope I've explained it better this time.

  • orange1
    orange1 Member Posts: 930
    edited January 2010

    Hi Sheila,

    Thanks for the clarification - your explanation makes sense. 

    I was referring to Yazmin's post:  It is so sad that Research remains confined to the "same old, same old, same old" despite the fact that you are pointing to: that most of the people treated the conventional way will eventually die of cancer.  

    I felt the need to point out the fact that ~ 80% overall survive BC, so the newly diagnosed will not freak out. 

  • Anonymous
    Anonymous Member Posts: 1,376
    edited January 2010

    Can you give a source for that statistic please?

  • thenewme
    thenewme Member Posts: 1,611
    edited January 2010

    Statistics here:  http://seer.cancer.gov/faststats/

    Oops - edited to fix link.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited January 2010

    That link doesn't provide the 80% you claim. That link is for the BCO organization????

    I'm familiar with the SEER database and that's not the way they keep stats.

    Could you provide a specific published peer review citation for the 80%?

    Thanks so much.

  • thenewme
    thenewme Member Posts: 1,611
    edited January 2010

    Hi Lucy, I corrected the link, but I'm not sure what you mean about the SEER database.

    The link I posted is an interactive tool to get statistics on a variety of factors.  I'm not able to post a link directly to the results I got, but it showed a graph of survival rates for female breast cancer for all ages and races for the period 1988-2005.  The survival point at 0 years was 100%, and went down linearly to just above 80%.  

    Peer-reviewed publications are generally for subjective research findings; this is simply an objective statistical number report.  I must be misunderstanding your question.

    In any case, this thread is about IP6 - didn't mean to get off track.

  • Yazmin
    Yazmin Member Posts: 840
    edited January 2010

    Hi, thenewme:

    I was going to ask you this same question, but Lucy88 already did:

    --------------

    13 hours ago lucy88 wrote:

    Can you give a source for that statistic please? [statistic according to which 80% of patients survive breast cancer]

    -------------------------------------------------------------------------------

    80% of patients survive with conventional treatments? Our highly conventional web site here, breastcancer.org, does not seem to concur, in this article they posted quite a while ago, entitled:

    Breast Cancer often not Ultimate cause of Death:

    Please see the last sentence in boldface, below

    Of course, what they are talking about in this article is the fact that older women diagnosed with breast cancer usually end up dying of other causes. GREAT finding Wink: most of us could have told them about this decades ago.

    Anyway, going back to the question of dying of breast cancer, I feel it is pretty safe to assume that they are referring to people treated the conventional way (ultimately dying of cancer anyway), or did I get  something wrong?

    ------------------------------------------------------------------------------

    NEW YORK (Reuters Health) - Older women treated for a common type of breast cancer and who survive past the five-year mark will probably not die from the disease, a new study shows.

    "For those ladies that fall into that category, it's wonderful news," Dr. Judith-Anne W. Chapman, the study's lead author, told Reuters Health. "They are essentially, most of them, surviving their breast cancer and having very low toxicity" from cancer treatment, she added.

    Understanding mortality due to other causes among breast cancer patients is becoming increasingly important as survival improves, Chapman, with the National Institute of Canada Clinical Trials Group at Queen's University in Toronto, and her team point out in the Journal of the National Cancer Institute.

    "Usually the perception has been up until now that if you had breast cancer ultimately you would die of breast cancer," Chapman said. "More and more reports are coming out now that if you are older, you have a better chance of dying of something else."

  • thenewme
    thenewme Member Posts: 1,611
    edited January 2010

    Hi Yazmin,

    I'm not understanding your reasoning at all.  I don't see the relevance of the article you posted.  How does it prove/disprove that 80% of patients survive breast cancer?  Do you know of sources with different survival statistics?  Of course overall survival statistics are much less useful than more narrowly-defined statistics applicable to individual circumstances. This should probably be a thread of its own, since it isn't about IP6.

    I did post the source for the statistics I cited:   www.seer.cancer.gov

    According to SEER:

    Relative Survival Rates By Survival Time
    By Cancer Site
    All Ages All Races Female
    1988-2005

    Cancer Site   Survival Interval          Rate
                                    (years)
    Female Breast           0                     100
    Female Breast           1                     97.5
    Female Breast           2                     94.7
    Female Breast           3                     92
    Female Breast           4                     89.8
    Female Breast           5                     87.8
    Female Breast           6                     86.1
    Female Breast           7                     84.5
    Female Breast           8                     83.2
    Female Breast           9                     81.8
    Female Breast          10                    80.7

    Cancer sites include invasive cases only unless otherwise noted.

    Survival source: SEER 9 areas (San Francisco, Connecticut, Detroit, Hawaii, Iowa, New Mexico, Seattle, Utah, and Atlanta).

    Survival rates are relative rates expressed as percents. The annual survival estimates are calculated using monthly intervals.  

  • Yazmin
    Yazmin Member Posts: 840
    edited January 2010

    Sorry, thenewme:

    I am sure I have made things more confusing. The part that really caught my eye is the sentence in bold.

    For the longest time, I have felt that research (but not all treating doctors) does not even think in terms of long-term survival (the newest drugs presented like "miracle" drugs often offer a matter of months of survival; even 1 extra month of survival is presented like a "huge" victory over cancer). Hence my reaction to this particular sentence.

    Thank you for the survival rates table above. I believe this is extracted from documents similar to the ones we receive from most of our oncologists?

    It usually goes something like this: [surgery alone: --% survival; surgery and chemo: --% survival (higher); surgery plus chemo plus hormonal treatment: --% survival (still a higher figure in those tables)]......Beautiful. But when one starts looking into some of the lingo used in those same documents (such as "disease-free survival", "time to progression", etc....), is when one might start asking more questions. Those are all relative figures, I totally agree with your document on that one.

    From time to time, of course, some little sentence, somwhere, might cause us to wonder.

  • Husband11
    Husband11 Member Posts: 2,264
    edited January 2010

    Adjuvent online doesn't present relative survival, it presents the data in actual survival numbers for the individual.  That is the data and the way it was presented to my wife by her oncologist.  It would say 30/100 survive disease free with no treatment other than surgery, 55/100 survive 10 years disease free who take chemo and 66 /100 survive disease free for 10 years with all therapies combined (for instance).

  • Yazmin
    Yazmin Member Posts: 840
    edited January 2010

    Ah, OK, Thanks, Timothy.

  • Husband11
    Husband11 Member Posts: 2,264
    edited January 2010

    Back to IP6.  Anyone have any suggestions for whether or not to spring for the higher cost IP6 plus inositol formulations?  What is an effective dosage?  I've heard up to 8 grams daily, but that's going to cost a pretty penny to keep up.  Also, do you take it high dosage, indefinately?

  • fairy49
    fairy49 Member Posts: 1,245
    edited January 2010

    Inositol is in my multi, I will have to check how much.

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