Extra Virgin Olive Oil May Help To Combat Breast Cancer

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Extra Virgin Olive Oil May Help To Combat Breast Cancer

ScienceDaily (Feb. 10, 2009) — UGR News Researchers of the Catalonian Institute of Oncology (Spain) and the University of Granada (Spain) have discovered that extra virgin olive oil may help to combat breast cancer, according to a paper published in a recent issue of ‘BMC Cancer’. The scientists have confirmed the bioactivity of polyphenols (this is, natural antioxidants) present in olive oil in breast cancer cell lines.

The study has shown the anti-HER2 effect of fractions of phenolic compounds directly extracted from extra virgin olive oil in breast cancer cell lines.
They have used solid-phase extraction methods of semi-preparative liquid chromatography to isolate fractions of commercial oils and, later, separation techniques (capillary electrophoresis and liquid chromatography connected to mass spectrometry) to check the purity and composition of the fractions.

Such fractions were tested in their anti-cancer capacity both against positive HER2 and negative HER2 breast cancers, using in Vitro models and evaluating the effect of polyphenolic fractions in the expression and activation of HER2 oncoprotein through ELISA specific methods for HER2. Fractions containing polyphonels such as hydroxitirosol, tirosol, elenolic acid, lignans, pinoresinol and acetopinoresinol, and secoiridoids, diacetox oleuropein aglycone, ligustrosid aglycone and oleuropein aglycone were able to induce important tumoricid effects in a range of micromolar and in a selective way against HER2 oncogene.

Therefore, this study confirms the potentiality of polyphenols to inhibit HER2 activity and to promote its degradation. Such results, together with the fact that humans have consumed secoiridoids and lignans safely for a long time through oil and olive oil consumption, endorse the fact that such phytochemicals could be an excellent and safe basis for the design of new antiHER2 compounds.

This work has been carried out by Javier A. Menéndez, coordinator of the Translational Research Unit of the Catalonian Institute of Oncology (ICO) in Girona, and by doctors Alberto Fernández Gutiérrez –in charge of the “Research Group of Analytic, Environmental, Biochemical and Food Control”- and Antonio Segura Carretero, member of such group.

This Research Group of the Department of Analytical Chemistry of the University of Granada (Spain) has developed other interesting research works in the characterization of polyphenolic profiles of an important number of plants and metabolomic studies of extracts with proved bioactivity through the use of advanced separation techniques.
Adapted from materials provided by Universidad de Granada.

Universidad de Granada (2009, February 10). Extra Virgin Olive Oil May Help To Combat Breast Cancer. ScienceDaily. Retrieved February 11, 2009, from http://www.sciencedaily.com­ /releases/2009/02/090205113743.htm
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Comments

  • FloridaLady
    FloridaLady Member Posts: 2,155
    edited February 2009

    Very interesting....

  • marejo
    marejo Member Posts: 1,356
    edited February 2009

    I take a tablespoon of extra virgin olive a day - just like I'm taking medicine.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited February 2009

    Remember that in vitro means in a lab dish.

    Thousands of things that are "anti cancer" in lab dishes have no effect in vivo (in people).

    It's promising, and there is good data about olive oil and heart health, but I wouldn't expect olive oil to cure breast cancer, prevent a recurrence, or even necessarily slow down growth. If it did, no woman in Italy would have breast cancer.

  • FloridaLady
    FloridaLady Member Posts: 2,155
    edited February 2009

    Ladies do your own research and make your own decisions.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited February 2009

    FloridaLady, do you know of any organizations providing funding for us to do our own research? Like on the order of the millions of dollars it takes to do actual research?

    I'd like to quit my day job and do research exposing the fraud of false cancer remedies.

  • Deirdre1
    Deirdre1 Member Posts: 1,461
    edited February 2009

    I don't think anyone would mind if you "quite your day job and do research exposing the fraud of false cancer rememdies" that actually can do some good too - maybe see if the FDA is hiring.. Anything on either EXTREME side is dangerous - but I don't believe anyone is suggesting anything extreme here.

    So ladies (and gents) do your own research and make your own decision is good advice.. check out other countries where trials have been allowed if you are a stats person and if that particular item, in this case extra virgin olive oil, seems like it might be a good thing for you, your immunity, your mind, body and/or soul then you go for it!!!  

  • FloridaLady
    FloridaLady Member Posts: 2,155
    edited February 2009

    Who funding our own research. WE ARE! It's called freedom and guess what we still are a free country!

    Flalady

  • desdemona222b
    desdemona222b Member Posts: 776
    edited February 2009

    Hi, saluki.  I don't know about preventing cancer, but EVOO is very good for you, so it certainly can't hurt to have a couple of teapsoons every day, which is what Weight Watchers recommends.  If you exceed that amount on a daily basis, I think it could possibly cause some weight gain.

    I cook everything with EVOO now - it is so delicious.  Something I really enjoy is to prepare some potatoes and green beans with a little rotisserie chicken added in, then drizzle 2 tsp on EVOO over it.  Add salt and pepper to taste and you've got a delicious, easy meal.  You can also put 2 tsp in oatmeal - it doesn't change the flavor, in fact you can hardly tell it's there.

  • priz47
    priz47 Member Posts: 470
    edited February 2009

    I wonder if cooking with olive oil makes a difference. I use alot in cooking, but the heat may break down whatever the good stuff is called. Good to know that it CAN help and yes, doing research is beneficial.

    D

  • desdemona222b
    desdemona222b Member Posts: 776
    edited February 2009

    Also, supposedly it is better to have unheated EVOO because heating it changes the molecular structure.  Don't know for sure if that is true, though.

  • desdemona222b
    desdemona222b Member Posts: 776
    edited February 2009

    priz -

    Our posts crossed!  What a coincidence!  Surprised

  • saluki
    saluki Member Posts: 2,287
    edited February 2009

    EVOO has a very low smoking point.............

    ----------------------------------------------------

    This from The George Mateljan Foundation 

    Practical tips

    "In principle, organic, unrefined, cold-pressed extra virgin olive oil should have the lowest smoke point of all forms of olive oil since this form of the oil is the least refined, most nutrient dense and contains the largest concentration of fragile nutritive components. Based upon this, I cannot imagine exposing this type of olive oil to high heat, anymore than I can imagine exposing fresh organic flax oil or evening primrose oil. For a natural, very high-quality extra virgin olive oil, I believe the 200-250°F range reflects the most likely upper limit for heating without excessive damage. In other words, this would allow the use of extra virgin olive oil for making sauces, but not for 350°F baking or higher temperature cooking. It is best to add it to your dishes after they have been cooked to enjoy the wonderful flavor and nutritional value of olive oil. "

  • FloridaLady
    FloridaLady Member Posts: 2,155
    edited February 2009

    Phenols in Quality Olive Oil Suppress Breast Cancer Gene

    WEDNESDAY, Dec. 17 (HealthDay News) -- Spanish researchers have identified anti-cancer chemicals in extra-virgin olive oil that may help explain the apparent link between eating an olive oil-rich Mediterranean diet and a reduced risk of breast cancer.

    Latest Cancer News

    Extra-virgin olive oil, which is produced by pressing olives without the use of heat or chemical treatments, contains phytochemicals that are otherwise lost in the refining process. The Spanish researchers separated extra-virgin olive oil into fractions and tested these against breast cancer cells in the lab. They found that all the fractions that contained major extra-virgin phytochemical polyphenols (lignans and secoiridoids) effectively inhibited the breast cancer gene HER2.

    The study was published in current issue of BMC Cancer.

    "Our findings reveal for the first time that all major complex phenols present in extra-virgin olive oil drastically suppress overexpression of the cancer gene HER2 in human breast cancer cells," Javier Menendez, of the Catalan Institute of Oncology, said in a BioMed Central news release.

    While the study results offer new insights into how extra-virgin olive oil may help reduce HER2 breast cancer risk, the findings must be viewed with caution.

    "The active phytochemicals [i.e. lignans and secoiridoids] exhibited tumoricidal effects against cultured breast cancer cells at concentrations that are unlikely to be achieved in real life by consuming olive oil," the researchers noted.

    However, they also said their findings, "together with the fact that humans have safely been ingesting significant amounts of lignans and secoiridoids as long as they have been consuming olives and extra-virgin oil, strongly suggest that these polyphenols might provide an excellent and safe platform for the design of new anti-breast cancer drugs."

  • FloridaLady
    FloridaLady Member Posts: 2,155
    edited February 2009
    Olive Oil May Help With Cancer
    Jan. 10, 2005
    (WebMD) A fatty acid found in olive oil may reduce the production of a protein from a gene associated with breast cancer, according to a new study. The findings may explain why a Mediterranean diet rich in olive oil appears to protect against breast cancer.

    Researchers found that the oleic acid found in olive oil dramatically reduces the levels of a protein produced by the breast cancer gene Her-2/neu, which occurs in more than a fifth of women with breast cancer and is associated with particularly aggressive tumors. Olive oil is the richest natural source of this fatty acid.

    Doctors use Her-2/neu to help predict treatment response in women with breast cancer.

    "To our knowledge this is the first report that a dietary monounsaturated fatty acid previously suggested to be protective against breast cancer significantly down-regulates the expression of Her-2/neu, cutting it by up to 46 percent," says researcher Javier Menendez, PhD, an assistant professor at the Northwestern University Feinberg School of Medicine, in a news release.

    In addition, researchers found that oleic acid's effect on this breast cancer gene also enhanced the effectiveness of the breast cancer drug Herceptin in at least two ways. First, by promoting the death of breast cancer cells with high levels of this gene, and second, by decreasing the accumulation of a protein thought to foster resistance to Herceptin treatment. This protein also plays a key role in the onset and progression of Her-2/neu breast cancer.

    Although previous studies of people in southern Europe who eat a diet rich in olive oil appear to have a lower risk of breast cancer, researchers say that until now very little has been known about any specific mechanisms that may explain olive oil's potential anticancer effects.


    Olive Oil Ingredient May Reduce Breast Cancer Risk

    In the study, which appears in Monday's edition of the Annals of Oncology, researchers analyzed the effects of oleic acid on breast cancer cells in the laboratory. They also evaluated oleic acid's effect on the breast cancer drug Herceptin.

    The study showed that oleic acid decreased the production of proteins produced by the breast cancer gene Her-2/neu by up to 36 percent. Researchers say this anticancer effect was almost as strong as that produced with Herceptin treatment, which reduced expression by up to 48 percent.

    When the two treatments were combined, researchers found that the two substances appeared to work even more effectively and reduced protein production by up to 70 percent.

    Menendez says the findings should not only help researchers better understand olive oil's potentially anticancer effects, but they also suggest that dietary changes that increase the amount of olive oil in the diet may be delay or prevent resistance to the drug Herceptin in some breast cancer patients.
  • trigeek
    trigeek Member Posts: 916
    edited February 2009

    I am originally from Turkey and the Mediterranean dish has lots of cooking with olive oil. However due to the heat-intolerance of olive oil I cook my vegetables with canola oil and then after the vegetable is cooked I add the evoo.

    Here is a classic recipe for green beans:

    Place in the pan in the order below:

    2 small packs of frozen green beans

    1 whole onion(placed on top of the green beans)

    1/2 can of chopped tomatoes

    1 tsp sugar ( sorry .. yeah we add sugar while cooking veggies- not that much but it makes it a lot tasties and the kids love it too)

    1/2 tsp salt

    1/4 cup of canola oil

    Add some water until you can see the water ( but not until it covers the beans)

    After boiling, simmer for 30 minutes.

    Add 1/4 cup olive oil

    Remove the onion.

    This dish is eaten cold as a side dish.. and we cook green beans, pinto beans, leeks and several other vegetables this way.

    Enjoy !

  • Deirdre1
    Deirdre1 Member Posts: 1,461
    edited February 2009

    Sounds really good trigeek!  And even if you "don't like vegie" the chopped tomatoes probably change the flavor of the green beans, pinto beans and other vegies enough so that most people could enjoy this!!1  Thanks

  • sarabhealed
    sarabhealed Member Posts: 179
    edited February 2009

    I think EVOO is great but had avoided it in cooking and baking for the reasons cited previously. I just learned a neat tip from a dietician teaching a class at the Wellness Community--she said the best oil to use in cooking and baking is grapeseed oil--she said it was the highest oil in essential fatty acids and adds no taste to the finished product. She said it did not cost a lot, was available in many regular grocery stores and she used it in all of the recipes she demonstrated  that day...

  • vivre
    vivre Member Posts: 2,167
    edited February 2009

    I use grapeseed oil too for cooking since EVOO does burn at high temps. I also use sunflower oil because I figure sunflowers are not sprayed with pesticides. I too afraid of canola oil after googling it and seeing what they put in it. I also use grape seed and sunflower oil as a moisturizer since most moisturizers are still full of carcinogens. I know I sound paranoid, but better safe than sorry. Did you know that appplesauce can be used in place of oil for baking? Great for brownies.

  • Anonymous
    Anonymous Member Posts: 1,376
    edited February 2009

    Sunflower may not be the best choice as it has a high level of Omega 6 fatty acids. Polyunsaturated fats should be kept at lower levels than other more beneficial fats.

    Canola is an excellent choice if you get the right kind. Look for expeller-pressed organic varieties. Trader Joes has this at a great price.

  • Deirdre1
    Deirdre1 Member Posts: 1,461
    edited February 2009

    About applesauce (and apple juices) be careful, there was a recent article in some digest (can't remember right now I see if I can find it) regarding all but a few manufacturers being made in China and then beings sold under the names we have come to know and love and believe to be healthy.. so look for all the small print.. So many of our products are produced in China now and with all the health scares there those products are now all questionable..  And yes I am generalizing but until they clean up their acts I will continue to be cautious of ALL products coming out of a country with so little checks and balances. 

  • crazy4carrots
    crazy4carrots Member Posts: 5,324
    edited February 2009

    Re applesauce:  Why not make your own, using organically grown local apples?  This way you can limit (or omit) the sugar and can be asured there are no additives or preservatives.

    Apples (over 1,000 varieties, I hear) are abundant in North America -- a great food, even if they don't really keep the doctor away!

  • Anonymous
    Anonymous Member Posts: 1,376
    edited February 2009

    EWG lists apples near the top of pesticide-laden produce.

    Always buy organic ones.

  • Deirdre1
    Deirdre1 Member Posts: 1,461
    edited February 2009

    Yes lindasa applesauce is very easy to make too and as you said you can put or or omit sugar or cinnumon etc..  Yummm and LJ13 it's true it's not a bad idea to buy organic.

  • FloridaLady
    FloridaLady Member Posts: 2,155
    edited February 2009

    I try to get olive oil through salad dressings.  But....I hate oil base salad dressings.  The whole salad dressing things get me every time.  Anyone have a really good oil based salad dressing that could move me into likely this stuff?

    Trigeek I'm going to try your beans recipe.

    Flalady

  • crazy4carrots
    crazy4carrots Member Posts: 5,324
    edited February 2009

    FlaLady:  Go to the Healthy Recipes thread and check out the vinaigrette recipe I posted there.  You can add your own favourite ingredients or take out ones you don't like, for example extra garlic, onions, herbs etc.   I never, ever buy prepared salad dressing.

    Linda

  • Anonymous
    Anonymous Member Posts: 1,376
    edited February 2009

    One thing that helps immeasurably is to buy a small immersion mixer. I got one at Walmart for about $15. It emulsifies the oil and vinegar so that it does not separate.

  • crazy4carrots
    crazy4carrots Member Posts: 5,324
    edited February 2009

    Yep, that's what I use for my vinaigrette!

  • Anonymous
    Anonymous Member Posts: 1,376
    edited February 2009

    Me too. Trader Joes has a 21-Season blend that I use to make my own dressing. I can't quite get the mixture I want of oil to vinegar. I'm using organic balsamic and organic EVOO.

  • vivre
    vivre Member Posts: 2,167
    edited February 2009

    I never buy salad dressings. They sneak all kinds of nasty things into them. The main thing you have to remember is to buy a really good quality olive oil and vinegar. If these are rancid, you will never get a good dressing. The vinegar is especially important because it can overpower a salad dressing. Vinegars come in all different types, balsamic, red wine, rice wine, etc. Keep trying different ones to taste. Use a proportion of 3 parts oil to 1 part vinegar and you can't go wrong. From there you just add whatever you want, herbs, mustard etc. and of course minced garlic. There really is no need for a recipe, just add things you like to taste. You can pulverize it all in bullet blender or just shake it in a jar. I only make it as I need it. Olive oil will solidify in the fridge and vinegar needs to be kept refrigerated so it is best to mix just what you need. If you do not like garlic, you can always put a couple of cloves in the vinegar and flavor it instead of on the salad, but garlic is so good for you, try to eat as much as you can.

    Sometimes I do not even use a salad dressing. I mashed up an avocado with some store bought fresh picodegallo and mixed it with fresh spinach for an easy and tasty spinach salad.

    I also sometimes buy olive tapenade and use that as a salad dresssing. Trader Joes has a good variety of tapenades.

    If you are in a resturant, just ask them to bring you vinegar and oil. Remember the ratio and put the oil and then the vinegar.

  • saluki
    saluki Member Posts: 2,287
    edited February 2009

    TJ's sun-dried tomatoes are delicious.  I usually use TJ's organic EVOO and because I do allot of Asian dishes I' get Hain's Peanut oil from WF.

    My problem is I don't use oil's like walnut or grapeseed as frequently, As a result I'm afraid I won't know when they are rancid.............

    Any rules of thumb?

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