Paxlovid and CDK4/6 inhibitors

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nnguyen
nnguyen Member Posts: 57
edited April 2022 in All things COVID-19 or coronavirus

Happen to run across an article that shows un-expected anti-tumor effect (via bone microenvironment) of CDK4/6 inhibitor, particularly abemaciclib. This might explained (in addition to denosumab) why tumors in my wife bone's met are stabled while those in the lung are not. Anyway, I noticed CDK4/6 drugs are metabolized by enzyme CYP3A4.

When Paxlovid first came out, I read up on its mechanism of action and noticed that ritonavir (paxlovid composes of ritonavir and nirvatravir) "uses" CYP3A4 pathway. So I am almost certain that if you are on CDK4/6 inhibitor (abemaciclib, palpociclib, ribociclib), be sure to discuss this possible drug interaction with your doctor if needing to use Paxlovid.

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  • nnguyen
    nnguyen Member Posts: 57
    edited April 2022

    I found drugs interaction sites, www.drugs.com, medscape.com, and webmd.com. All 3's confirm interaction between Paxlovid and Abemaciclib. But only drugs.com shows interaction between Paxlovid and ribociclib or palpociclib.

    Nguyen

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