Anyone enrolling in DESTINY Breast05 (HER2+, no PCR)?

Sarah_78

I will have surgery at the end of January, beginning of February. The primary lesion still feels hard to touch so I am expecting some cells lingering between scar tissue there, preparing for no PCR and if PCR comes, it will be a nice surprise for me (I'd be so grateful).

I was checking my options for no PCR and it seems now protocol in Germany (and in the States from what I read) is Kadcyla instead of Herceptin after surgery (for 12-14 more treatments?). Another option seems to be getting enrolled in DESTINY Breast05 and roll the dice for 50% to Enhertu arm. More about that trial here.

I am reading Enhertu has proven to be more effective with less side effects (although latter can be debated perhaps) and might replace Kadcyla in protocol for early breast cancer patients with no PCR, seems like a good thing to fill out a few forms and roll the dice. Nothing to lose after all since Kadcyla is anyway what I will be getting if I don't enroll in this study.

Anyone already enrolled or thinking to?