Understanding what ER+/PR-/HER2- means for me

Maybe_Maeby

Hi all, can anyone help me decipher how “good” or “bad” this is for me? This is a new occurrence in other breast (had pure DCIS just over two years ago). The spot is pretty tiny (2mm) per MRI but Dec 2018 MRI shows it was there. It has grown 1mm in that time and only now took on a suspicious outline. It was never noted to me earlier. Other things I know is that Ki-67 is 10%. I was surprised to hear oncologist mention it would be better it was PR+ too. I didn’t know that, but admittedly have a lot to learn yet since this was a non-issue with my DCIS. Can anyone help me understand why and how serious is it that it’s not also PR+? I’ll note I’ve been on tamoxifen since my SMX. I suppose that is what has kept this so small. Thanks in advance.

MelissaDallas

Maybe_Maeby, it would be really helpful if you asked this question in your last thread, rather than starting a new one. All the info previously provided is pertinent to the discussion, and missing from this new thread.

Maybe_Maeby

Melissa, do you mean my post back in waiting for a diagnosis? Sorry, I didn’t think it fit there any longer but I can certainly do that.

moth

Maybe, do you know how strong your ER is? Generally speaking, there is some indication that both ER and PR + is a good sign - more likely to respond to hormone therapy. Wit ER+/PR- there is a bit less response. And if ER is weak, or both are weak (like in the =< 10% range) then some of those cancer behave like triple negative.

MelissaDallas

https://community.breastcancer.org/forum/62/topics/879291?page=1#post_5649731

Maybe_Maeby, your prior thread where you say that your cancer is invasive with details. Your prior posts don’t go away. Everything builds on previous information.

Maybe_Maeby

Thanks for the guidance, I think I have successfully moved it all to the other post. Sorry got the newbie mistake!