ER/PR/HER2 Status

JACK5IE

I recently noticed that my PR status changed with my metastatic diagnosis. In 2009 when diagnosed Stage 2C, I was ER+PR+/HER2-. When I was biopsied again in 2018 after my metastatic diagnosis I was ER+PR-/HER2-. I briefly talked to my MO about this but he doesn't like to go to the negative because he believes everyone reacts differently to treatment and stats have so many variables. I try to stay that course but sometimes my fear creeps up out of the blue. So I'm just wondering how many of us have changed after initial diagnosis and does changing mean we have a less favorable outcome with treatment?

Cure-ious

JACK6IE-It does not. My cancer had a similar switch to PR-negative, and those cancers can be less endocrine-sensitive. The PR gene can be turned on by ER,so when PR is not expressed, it can mean ER signaling is rather weak. However, in other cases, ER activity is fine but the PR gene is shut off by other factors. My cancer switched from PR-positive to -negative but still responded for 5.5 years to Ibrance-Femara.

JACK5IE

Thank you Cure-ious. I'm having a little bit of a tough time today. Happens every so often. I appreciate your post. Thanks again.

Tinkerbell107

JACK6IE-: I went from being 95%ER/PR+ (primary tumor) to a bone biopsy (spine) which was ER (weak) and PR- in 1 month. Both MOs (had 2nd opinion) when initially diagnosed didn't feel the bone biopsy results had a lot of weight or credibility. Actually the MO who provided the 2nd opinion was more interested in genetic mutations, rather then the ER/PR status. So I contacted foundation one, which provided more insight and avenues for the future.

JACK5IE

Thank you Tinkerbell.