Looking for research on chemo with node+ Er+ lobular
I don't know where to start. I know there's going to be a disagreement on how to treat me adjuvantly as there was before surgery, so I need to find research so I can ask good questions and hopefully make a good decision. Just had surgery after 6 months on neoadjuvant letrozole. My final path was bad. 2.4 cm (much smaller than we expected), but 8/11 nodes. LVI and extranodal. Luminal A Lobular. Stage 3a. Oncotype submitted from original biopsy with one pos node came back 13. Mammaprint low risk, no apparent benefit. Since surgery I've read that the higher cancer burden doesn't change the science....yes the prognosis is poor, but that chemo won't change that in certain cases. One of my docs believes that there's no benefit, the science on Luminal A lobular responsiveness to chemo just is too strong. He says to say we must do something big because this is bad is emotion, not science. I know the other doc is going to want ACT. I am willing to do whatever will work, however difficult. I am a single mom with a young daughter who I need to raise, and who has nobody but me. But if there's truly no benefit, if the risks far outweigh the benefit, then I don't want to spend what's left of my life with her, in a compromised state from SE of a treatment that had no chance. I need research so I know how to decide this. Can anybody point me in the right direction? Where to start? Beesie?
Also edited to add, I was 99% Er+, 99% PR+, her2-. Original ki67 was 23, after one month on letrozole ki67 dropped to .4 (below 1), though I have doubts now that that was correct. I’m scared they may have just missed the tumor or something on the second biopsy.
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