Supplements that may inhibit Covid 19 / Coronavirus

Husband11

https://www.google.com/url?sa=t&rct=j&q=&esrc=s&so...

5. Conclusions

Currently, COVID-19 has emerged in the human population, in China, and is a potential threat

to global health, worldwide. However, no approved drug currently exists to treat the disease. The

currently available drugs for COVID-19 treatment primarily act on the main protease (Mpro). The aim

of this study was to examine several medicinal plant-derived compounds that may be used to inhibit

the COVID-19 infection pathway. Nelfinavir, lopinavir, kaempferol, quercetin, luteolin-7-glucoside,

demethoxycurcumin, naringenin, apigenin-7-glucoside, oleuropein, curcumin, catechin, and

epicatechin-gallate have the lowest binding energies and inhibition constants. The affinity of

kaempferol bonds is higher compared with other compounds. Therefore, we suggested that

nelfinavir and lopinavir may represent potential treatment options, and kaempferol, quercetin,

luteolin-7-glucoside, demethoxycurcumin, naringenin, apigenin-7-glucoside, oleuropein, curcumin,

catechin, and epicatechin-gallate were the most recommended compounds found in medicinal plants

that may act as potential inhibitors of COVID-19 Mpro. However, further research is necessary to

investigate the potential uses of the medicinal plants containing these compounds.

Quercetin Research ongoing

https://www.macleans.ca/news/canada/a-made-in-cana...

https://www.cbc.ca/radio/thecurrent/the-current-fo...

https://ircm.qc.ca/en/news/lazaridis-family-founda...

https://virologyj.biomedcentral.com/articles/10.11...

Chloroquine and Coronavirus induced pneumonia

https://www.unboundmedicine.com/medline/citation/3...

https://www.genengnews.com/a-lists/how-to-conquer-...

My comments:

Quercetin is an inexpensive, commonly available supplement, with very low side effects. Curcumin and catechin / epicatechin-gallate are all readily available as well. Both are often used for their purported anti-cancer benefits. The idea is that these supplements will interfere with the replication of the virus in the human body. Quercetin has proven efficacy for doing this with certain viruses, but it is not yet known whether it will work against the Coronavirus.

All of the above have potential to interfere with the metabolism of prescription drugs, and therefor should only be used in the absence of drugs to eliminate the risk of interference which could lead to either increased side effects or deceased activity, depending on the drug. Green tea concentrates have some potential for causing liver damage, so they should only be used as recommended. So this is something to be only used with medical advice and caution, and in the appropriate circumstances. It would seem to me, that out of an abundance of caution, one would only treat the virus once you have it, rather than take such supplements ahead of time in the hope of preventing infection.

Chloroquine is a prescription only drug used to treat malaria. The suggestion from the research is that it might interfere with the pneumonia brought on by the virus. Naturally, it would not be used as a prophylactic against getting the virus. It does have potential for severe side effects, although it is used commonly as a prophylactic against malaria.

Natural Sources of Quercetin and Kaempferol

2. Food Sources and Dietary Intakes

Quercetin and kaempferol are widely distributed in fruit and vegetables [16]. Table 1 shows the

average amounts in select major food sources. High concentrations of quercetin are found in a few

foods such as onion, asparagus, and berries, and small quantities are found in many di
erent fruit and

vegetables. The richest plant sources of kaempferol (mg/100 g fresh weight) are green leafy vegetables,

including spinach and kale, and herbs such as dill, chives, and tarragon. The leaves of wild leeks or

ramps (100g fresh weight) were reported to contain 50.2 and 32.5 mg of quercetin and kaempferol,

respectively [17].

Table 1. Select Plant Sources of Quercetin and Kaempferol.

Source Quercetin Kaempferol

Food mg/100 g fresh weight

Apples 4.01 0.14

Asparagus 14.0 1.40

Broccoli 13.7 7.20

Chili pepper 32.6 -

Chinese cabbage - 22.5

Kale 22.6 47.0

Leeks 0.9 2.67

Lettuce 14.7 0.84

Onions 45.0 4.50

Spinach 27.2 55.0

Chives 10.4 12.5

Dill 79.0 40.0

Fennel leaves 46.8 6.50

Oregano 42.0 -

Blueberry 14.6 3.17

Cherry 17.4 5.14

Cranberry 25.0 0.21

Wild leeks (whole) [17] 8.36 5.31

Beverage mg/100 ml

Black tea 2.50 1.70

Red wine 3.16 0.25

Sources: Phenol-Explorer and USDA (United States Department of Agriculture) Database for the Flavonoid Content

of Selected Foods.

Foods with the

highest concentrations of quercetin and kaempferol in plants are not necessarily the most bioavailable

sources. Glucoside conjugates which are found in onions appear to have the highest bioavailability in

humans.

ShetlandPony

Red grapes, apples, and green tea are good dietary sources of quercetin.

Simone80

This is good info. Thanks for the post.

Anonymous

There's a trial of a derivative of quercetin underway now, but it's one of at least 80 potential treatments.

https://www.macleans.ca/news/canada/a-made-in-canada-solution-to-the-coronavirus-outbreak/

I prefer to wait until there's more concrete evidence. Also, use of quercetin and green tea is contraindicated in patients underground chemo or taking meds like Ibrance, right?

Having said that, if I think I have covid-19, I would probably stop Ibrance and start drinking all the green and white tea currently in my house.

Anonymous

Everything I've read says a good probiotic won't hurt. That good gut bacteria is all important for our immune systems.

Husband11

More on chloroquine:

https://www.sciencedirect.com/science/article/pii/...

The first results obtained from more than 100 patients showed the superiority of chloroquine compared with treatment of the control group in terms of reduction of exacerbation of pneumonia, duration of symptoms and delay of viral clearance, all in the absence of severe side effects [4,5]. This has led in China to include chloroquine in the recommendations regarding the prevention and treatment of COVID-19 pneumonia [4,6].

ErenTo

Interesting stuff, Husband, and thank you for all the research. Matcha green tea is another good source of quercetin. I actually had just recently ordered quercetin (for its anti-cancer effect), but haven't started it yet. Maybe it's a good time to start. First I need to do some research on its interaction with Arimidex pathways though.

ShetlandPony

Doesn’t tonic water have quinine? Is that close enough?

wallycat

NAC is the only supplement I have seen researched for influenza/pulmonary issues. Covid is NOT influenza but may have similar upticks in pneumonia.

https://www.ncbi.nlm.nih.gov/pubmed/9230243

Anonymous

It does. Maybe. I’ll have to hold the lime due to Ibrance.

Husband11

I think if one was diagnosed with covid 19, its treatment would take priority and you would stop cancer treatment until you have the covid beat. I am attempting to secure some chloroquine to have on hand, just in case. In some countries it is available over the counter as prophylactic for malaria.

pipers_dream

Lysine is another supplement to look into. It’s usually used to hold back attacks of the herpes family, like shingles or genital herpes.

macb04

Black Elderberry is extremely effective for viral illnesses like influenza and Corona Virus.

People are getting erroneously warned away from Black Elderberry. Illogical.

There are NO Documented cases of Cytokine Storm from using Black Elderberry.

NONE.

Elderberry raising levels of helpful types of cytokines is not in the least bit the same as a destructive Cytokine Storm.

Read the research....

https://suzycohen.com/articles/in-defense-of-precious-elderberries/

santabarbarian

I have been on ~1g/day of quercetin throughout my treatment. and about 2-3g of curcumin among quite a few other antioxidants. (I took Taxotere and Carboplatin.) I was otherwise in good health and not on any other meds prior to treatment. It might be different with underlying conditions or other meds but I have never noticed any issue with quercetin. My Integrative Onc though quercetin was very valuable against BC.

wallycat

https://www.sciencedaily.com/releases/2020/04/2004...

(Treating COVID-19 in a patient with multiple myeloma

Tocilizumab shows promise in addressing COVID-19 symptoms for people with blood cancers)