BRCA 2 - VUS

petyab

Hi there - Posted this in the "Positive Genetic Test Results" Forum but no one responded.

I am 38. My mom had BC when she was 59 (er/pr positive her2neu negative). Her paternal cousin had same type of BC at age 50.

I recently had the 36 gene panel test through Ambry Genetics. BRCA2 came back variant of unknown significance.

I called Myriad (now Invitae). They shared their database shows two other individuals had this same VUS. One indicated they had a personal history of BC. One did not answer.

I am extraordinarily anxious and terrifie. Any advice?

Mamags

Hello,

I am not familiar with VUS. I am also BRCA2+, but i know the variant. I just found out 2 months ago so I am still learning. There is a website and message boards that may be helpful to you called FORCE.

I hope this can give you some of the answers you are looking for.

Hopeful82014

Given that BRCA 1 and 2 have been studied so extensively, I would think that any VUS would be unlikely to actually be pathogenic. Still, since you’re so concerned it might be worthwhile to have an in-depth conversation with your genetic counselor. Also, reach out to FORCE. Speaking with one of their peer counselors could be very helpful

djmammo

petyab

Make an appointment with a certified genetic counselor.

santabarbarian

what djmammo said....

In my case i had a VUS on TP-53. The known/significant variant on this gene produces Li Fraumeni Syndrome (multiple cancers beginning young). But I did not have that one... mine was different. In my case the info was leaning towards 'not significant' but that was not certain.

Try not to freak out, talk to a counselor and drill into the results a bit more to understand what it actually means. That other person with your variant having had cancer means very little.... First most people who get genetic testing have some kind of dread disease that motivates the testing. Second it is too small a sample to draw inferences from.