Brca2 VUS

petyab

Hi there - I am 38. My mom had BC when she was 59 (er/pr positive her2neu negative). Her paternal cousin had same type of BC at age 50.

I recently had the 36 gene panel test through Ambry Genetics. BRCA2 came back variant of unknown significance.

I called Myriad (now Invitae). They shared their database shows two other individuals had this same VUS. One indicated they had a personal history of BC. One did not answer.

I am extraordinarily anxious and terrifie. Any advice?

star2017

do you have access to a genetic counselor?

SimoneRC

I second meeting with a genetic counselor and/or genetic oncologist. If you have access to a National Cancer Institute Hospital that would be my recommendation.

On a side note, I believe that Myriad and Invitae remain separate, individual companies.

april1964

I tested positive for that but I never saw a genetic counselor... I tried to look it up but I don’t think that much is known...

april1964

In the letter that came with this it said Variant of Unknown Significance.

vlnrph

For our original poster, are either your mom (most likely a post-menopausal diagnosis) or the cousin available for testing? It appears that you are not actually a BC patient yourself.

If someone allowed your sample to be analyzed without having you initially consult with a genetic counselor they were irresponsible, in my opinion, by subjecting you to this kind of anxiety. Despite having a first degree relative with cancer, that is not a strong family history. Perhaps there are other risk factors which you haven’t shared.