Oncotype results

Eigna

does anyone know what s the difference between low risk and high risk Oncotype calculator ? And how do you interpret results

Beesie

You will receive a report that explains the results.

Are you over or under 50? The recommendations differ based on that age break. Here is a summary of the recommendations based on Oncotype scores (I think I got this right):

Scores 0 - 10 are low.

• Recommendation no chemo.

.

Scores 11 - 25 are intermediate.

• Recommendation no chemo for those over age 50.
• Recommendation no chemo for those age 50 & under with 11 - 15 scores.
• Recommendation to consider chemo for those age 50 & under with scores of 16 - 25.

.

Scores 26 and above are high.

• Recommendation to consider chemo for those over age 50 with scores 26 - 29.
• Recommendation for chemo for those over age 50 with scores of 30 and above.
• Recommendation for chemo for those age 50 & under.

.

This graph reflects the results from the TAILORx study released last year, which is now used to determine risk levels and the treatment recommendation based on the Oncotype score. The solid red line represents average recurrence rates for those who had Tamoxifen only, while the solid blue represents average recurrence rates for those who had chemo plus Tamoxifen. The dotted lines represent the highs and lows of the recurrence rate ranges. The top graph is for those age 50 & under and the bottom graph is for those over age 50. Note that everyone in the TAILORx study with a 26 or higher score was given chemo, which is why the red lines all stop at a 25 score.

Eigna

https://gsm.utmck.edu/nomograms/

What’s this tool and how do you interpret results?

Thanks for the info Beesie.

Beesie

I don't know what that tool is.

Here is the physician's guide from Genomic Health, the Oncotype people:

https://www.oncotypeiq.com/en-US/breast-cancer/healthcare-professionals/oncotype-dx-breast-recurrence-score/interpreting-the-results

Eigna

Anyone have grade 3 tumour stage 1 with low Oncotype score ? I’m hoping for low Oncotype results this week 🤞🙏🤞

Beaverntx

Eigna, yes. My oncotype was 17 which was classified as low with intermediate starting at 18. I had no chemo but radiation and now taking Tamoxifen. She may make a difference.

Eigna

Thanks Beaverntx !

Eigna

So nervous about my Oncotype results. I will know my score tomorrow. Please comfort me anyone.

Beesie

Eigna, I saw on another thread that you will be doing chemo. I'm sorry to hear that. I did have the feeling that with your cancer being PR-, low ER, and grade 3, and given your age, it was mostly likely that you'd have an Oncotype score leading to a recommendation of chemo.

What was your Oncotype score?

And how are you doing?

Eigna

Hi Beesie. They didn't do finally Oncotype testing because I'm weakly ER+ and everything else negative they are treating me as triple negative case 🙁. Yesterday I was devastated, shocked and fearful of what's coming up. The only positive of my appointment is that lymph nodes and margins are clear.

This morning I cried quite a bit. Just being on this site has helped me a lot. Right now I'm feeling so so ...but much better than yesterday. I'm just wondering what will my treatments be. I hope I don't need to do Taxol. 🤷♀️ It just sucks. When will this be over? How long will I live after treatments are over??

Beesie

Ah, I see. Although each province has it's own guidelines, there appears to be some consistency. From what I've seen, if based on the pathology and the patient's age, an MO knows from experience that he/she will either strongly recommend chemo, or strongly recommend against chemo, then the Oncotype test isn't done. If the Oncotype isn't going to influence the MO's treatment recommendation, then there is no reason to order the test.

From the very large TAILORx study, only 3% of patients who were PR- had a low Oncotype score. Adding in your low ER and grade 3, it's pretty much certain that you would not have had a low score. You might have had an intermediate score, but probably high intermediate at best. For younger patients, higher intermediate scores almost always lead to a chemo recommendation. And of course high scores lead to a chemo recommendation as well. So while you don't know what your Oncotype score would have been, I think you can be certain that the recommendation would have been the same.

Yes, it does suck. But you will get through it, one step at a time. And when it's done, to your question "How long will I live after treatments are over?", the answer hopefully is "a long long time, into your old age". Remember that the reason for the chemo is to increase your odds of getting to that very old age. Not fun by any means but if the chemo does it's job, the benefit is the most important thing of all.

Sending (((Hugs)))!

Eigna

Thank you Beesie. Hoping for the best outcome after all of this is done 🙏🙏🙏.

Eigna

Beesie,

I am still thinking about all this chemo treatment. I’m seeing the oncologist on Monday but till then my mind is working overtime. Does this mean I am triple negative or they are just considering me triple negative just for the treatment? What are my risk that this cancer will come back after treatment?

Cannot stop thinking!