Question about treatment option routes after AC

bcnav

Hi. I’ve posted some background before. But briefly my mom was diagnosed with TNBC IIB grade 3 with one tumor in breast and one in lymph node. We’ve completed AC with a 60% reduction in breast and 90% in lymph node. Oncologist has given us the following options:

1) Paclitaxel with carboplatin

2) nab-Paclitaxel with atezolizumab

3) Paclitaxel and carboplatin with panitumumab

The second option is the preferred because the initial biopsy had showed lymphocytes (TILs). I’ve done some research but I’m feeling quite overwhelmed. I’m just wanting to get some thoughts on her current response and the available options.

Thank you very much.

santabarbarian

Do they have a guess on the type of TNBC? TILs are a good sign for immune response...

Basal (and basal-like) TNBC tends to respond to carboplatin...

bcnav

Hi. I’m a bit confused on the types and basal designation... what are the different types of TNBC?

All they said was that there were TILs in the biopsy so it was favorable for immunotherapy. Otherwise the genetic panel of it only showed TP53 mutation, which I understand is common?