Luminal B with mets

bydand

My mom was recently diagnosed with de novo stage IV breast cancer with mets to (<4) bones. My understanding is that her tumor is luminal B: ER positive, PR positive but low, high Ki (23%).

I’ve read that luminal B cancer is relatively rare. Just wanted to hear the stories of those with this type of cancer

Murfy

Hi bydand: Luminal Bs tend to be fast-growing (hence high Ki) and aggressive tumors. Fortunately, they tend to respond well to chemo. Many are associated with that low/no PR. I'm 18 mos out and currently on an aromatase inhibitor for another 3.5 years, at least.

Here's hoping your Mom has an easy time through treatment. She's lucky to have you.

JFL

No, I don't believe Luminal B is rare at all. Mine is Luminal B. Luminal A may be somewhat more prevalent in older women but B is not at all rare. For young women, Luminal B, HER2 and basal-like are more common (than Luminal A, for example) as young women tend to have more aggressive cancers. On the one side, Luminal B is known to be aggressive. On the other side, aggressive, fast growing cancers tend to be very responsive to treatment, many of which target fast-growing cells. Another key factor is location and bone only has the best prognosis.