What comes after capecetibine?

CanaLoon

Hi. was diagnosed with BC 19 years ago. Went through 2 lumpectomies, 6 chemo, and 22 rad's. Then nothing happened. After 17 years of living a normal life, I started to cough. It took 18 months to diagnose Stg4MBC. A new trial was starting and they put me on that (Ribociclib etc). I think it saved my life. But it started to damage my liver (Late 2017) so after 4 cycles they took me off but it was enough to shrink the lung mets. I forget what they put me on next but it made me really sick, so now my oncologist has had me do I've 7 rounds of capcetibine. I was on a hormone med but they took me of that in Nov. After some experimenting, 10 days on and 14 days of chemo off seems to be what my body can handle. I don't want to stay on it forever and I know there's new meds out there. I watch OncLive.com for their reports and an impressed with all the updates and clinical trials going on. So what do you folks think my treatment team is likely to recommend next, or even more, is there something I should go in and ask for?

MJHJAN1014

My MO will probably prescribe Doxil for me after capecitabine, but I would by just as happy staying on capecitabine for the rest of my life. it is working for me and is tolerable. A lot depends on what you have been on previously. My MO says there are about six different chemotherapies available for me at the next juncture. Hope this helps! Regards, MJH

Sadiesservant

Hello from across the pond! Your story sounds achingly familiar. I too went many years until a cough took me to my GP. The rest is history as they say.

A lot of women stay on Capecitabine for a long time. I wouldn’t be quick to change if it’s working. I. My. Are it wasn’t clear if we were getting a response but I suspect I might go back on it at some point.

pajim

I was on cape for more than a year. When I developed a liver lesion my onc gave me five or six choices. Most of them were i.v. chemo, but one was a trial of an oral version of Faslodex and another was to take Verzenio.

I chose Verzenio and it didn't work for me. So then the choices were Halaven, Taxol or Navelbine.

You do want to stay on cape forever if you can. Or at least until the immunotherapies and the CAR-T therapies come on line. That's many years from now though. There's nothing wrong with 10 days on 14 days off if it's holding you stable or shrinking the lesions.