New study showed the role of omega 3 in preventing breast cancer

GinaGina1

how to prevent breast cancer naturally with fish-derived omega-3

some scientists showed that the fish oil derived omega 3 succeeded in preventing the development and metastasis of breast cancer cancerous cells to other body organs.

Saraswoti Khadge, (the author of the study which was published in journal Clinical & Experimental Metastasis) said that the tumors found in (omega – 3) group mice breasts were smaller by 50 % than the tumors found in (omega – 6) group mice breasts, the results also showed that the rate of growth and spreading of cancer cells to other body organs were lower and mice survival were longer in Omega – 3 mice group, beside this; some of mice in omega – 3 group didn't develop breast cancer

so i think it is an important role of omega 3 in preventing breast cancer, therefore you should ask your doctor to advice you to the omega – 3 healthy diet which suitable for your overall health

MelissaDallas

Clinical & Experimental Metastasis

December 2018, Volume 35, Issue 8, pp 797–818| Cite as

Long-chain omega-3 polyunsaturated fatty acids decrease mammary tumor growth, multiorgan metastasis and enhance survival

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Research PaperFirst Online: 16 October 2018

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Abstract

Epidemiological studies show a reduced risk of breast cancer (BC) in women consuming high levels of long-chain (LC) omega-3 (ω-3) fatty acids (FAs) compared with women who consumed low levels. However, the regulatory and mechanistic roles of dietary ω-6 and LC-ω-3 FAs on tumor progression, metastasis and survival are poorly understood. Female BALB/c mice (10-week old) were pair-fed with a diet containing ω-3 or an isocaloric, isolipidic ω-6 diet for 16 weeks prior to the orthotopic implantation of 4T1 mammary tumor cells. Major outcomes studied included: mammary tumor growth, survival analysis, and metastases analyses in multiple organs including pulmonary, hepatic, bone, cardiac, renal, ovarian, and contralateral MG (CMG). The dietary regulation of the tumor microenvironment was evaluated in mice autopsied on day-35 post tumor injection. In mice fed the ω-3 containing diet, there was a significant delay in tumor initiation and prolonged survival relative to the ω-6 diet-fed group. The tumor size on day 35 post tumor injection in the ω-3 group was 50% smaller and the frequencies of pulmonary and bone metastases were significantly lower relative to the ω-6 group. Similarly, the incidence/frequencies and/or size of cardiac, renal, ovarian metastases were significantly lower in mice fed the ω-3 diet. The analyses of the tumor microenvironment showed that tumors in the ω-3 group had significantly lower numbers of proliferating tumor cells (Ki67+)/high power field (HPF), and higher numbers of apoptotic tumor cells (TUNEL+)/HPF, lower neo-vascularization (CD31+ vessels/HPF), infiltration by neutrophil elastase+ cells, and macrophages (F4/80+) relative to the tumors from the ω-6 group. Further, in tumors from the ω-3 diet-fed mice, T-cell infiltration was 102% higher resulting in a neutrophil to T-lymphocyte ratio (NLR) that was 76% lower (p < 0.05). Direct correlations were observed between NLR with tumor size and T-cell infiltration with the number of apoptotic tumor cells. qRT-PCR analysis revealed that tumor IL10 mRNA levels were significantly higher (six-fold) in the tumors from mice fed the ω-3 diet and inversely correlated with the tumor size. Our data suggest that dietary LC-ω-3FAs modulates the mammary tumor microenvironment slowing tumor growth, and reducing metastases to both common and less preferential organs resulting in prolonged survival. The surrogate analyses undertaken support a mechanism of action by dietary LC-ω-3FAs that includes, but is not limited to decreased infiltration by myeloid cells (neutrophils and macrophages), an increase in CD3+ lymphocyte infiltration and IL10 associated anti-inflammatory activity.

Keywords

PUFA Omega-3 Mammary tumor Metastasis Survival

Abbreviations

AA

Arachidonic acid

BC

Breast cancer

CBC

Contralateral breast cancer

CMG

Contralateral mammary gland

DHA

Docosahexaenoic acid

EPA

Eicosapentaenoic acid

FA

Fatty acid

HO

Histologically observed

LC

Long-chain

MFP

Mammary fat pad

MG

Mammary gland

NTB

Non-tumor bearing

NLR

Neutrophil to lymphocyte ratio

PUFA

Polyunsaturated fatty acid

qRT-PCR

Quantitative real-time polymerase chain reaction

TB

Tumor bearing

AliceBastable

I've been taking Omega 3 for YEARS and I got two different cancers in 2018. It might not hurt, but it doesn't seem to help.

santabarbarian

Alice B-- my question would be, what is the ratio of Omega 3 to Omega 6 in your diet, overall? My understanding is that the ratio has to be right. Also what dose do you take? I am taking 1680 mg a day.

hapa

It seems pretty easy to cure breast cancer in mice. They've done it hundreds of times. Maybe even thousands. I'll pay attention when the human studies come out.

That said, I don't think eating extra omega 3s is going to hurt anything.

1redgirl

While I do take supplements, including flaxseed high in omega 3, nobody really knows if the amount taken is sufficient for that person to make any difference. I personally think radical lifestyle changes are required. So I ate a lot of sugar and carbs. I no longer do. I also ate into the late night. I fast now for at least 13 hrs daily. I avoid stressful situations. It is rare now that I get agitated. The results have been astounding. I sleep well. Never did. I was lucky to sleep 4 hrs. Now I can easily sleep 8 hrs. I stopped bruising. My skin is so soft. My nails finally grow. No more migraines. No more joint pain. I have tons more energy. I feel balanced. No more highs and lows. I have not had a headache in nearly a yr.