TNBC clinical trial PVX 410/durvalumab

member66

Anybody on this trial?

Adjuvant PVX-410 Vaccine and Durvalumab in Stage II/III Triple Negative Breast Cancer

Any side effects, any positive/negative results?

thank you!

Sam0623

Hi member66,

I have not participated in this trial but I did ask a Dr at Dana Farber about it (they are one of the study locations). I had residual disease after neoadjuvent chemotherapy and she did not recommend it for me- she said it is a dosing study and they are not yet testing for treatment response. Online it does look like they are measuring it, but I didn't do anything further since they didn't recommend it. She seemed to think the phase 3 Keytruda trial was a better option for those with residual disease.

Cstreb

I know this is a late response but I wish there had been a response posted when I was looking. I just finished the trial shots. I tolerated the shots well. The day after I would get a little feverish, but nothing that ibuprofen couldn't handle. My arm was sore for a few days, really sore day 2 and 3, and hard, red and itchy for a week. Nothing terrible though. I've mostly had joint pain and increased hot flashes. The hot flashes come on quick and intense and only last a minute or two but happen multiple times a day. I also have related night sweats. As for the joint pain, that has gotten increasing worse. It started about half way through as hip pain when going from sitting to walking. It's been 3 weeks since last shot and now it feels like if I hurt a joint (rolled an ankle in heels, slept wrong on wrist) it's not healing. My joints feel beat up but not something debilitating or the I need medicine for. Just annoying.

As for the trial itself, it measures drug tolerance rather than effectiveness. However they did add some more effectiveness monitoring steps. I'm glad I did it though. There has been so much success reported with immunotherapy. And, since the "standard of care" monitoring for tnbc is crap, at least I have someone watching for the next few years.

Moderators

Thank you so much for sharing your experience with this trial, Cstreb! We sincerely hope it proves to be helpful for you, and that some of the issues you mentioned resolve soon!

The Mods