Please help with biopsy interpretation

nally18

Hello everyone

My lovely Mom ,68 was just diagnosed with invasive breast cancer- lobular carcinoma

Last year she had surgery with left breast (cancer removed) and then chemo but she was feeling good after chemo and this year it's time for her left breast...

Can somebody take a look at her below biopsy result and give me some advise

How aggressive is cancer and if she decide to mastectomy what is possibility he will come back again

Does she really need chemo after surgery or just radiation or hormonal therapy? (really scared of chemo as it's not good for other organs)

Biopsy Result:
Left , 8-3 cm from the nipple on the soil. 8 mm,
change of blurred outlines, Dim. 17 mm, birads B4B

-Cancer Invasive lobular carcinoma, fibrous type
-P5- invasive cancer
-in situ cancer does not occur
-G: 2
-estrogen receptors (%) ER: 90
-intensity of staining -average
-progesterone receptors PR: 0
-HER-2 receptors: + 2
-Ki67 (%): 20
-IHC: e-cadherin (-)
- Lymph node no change

THANK YOU! IN ADVANCE FOR YOUR HELP!

Moderators

Hi Nally, we're sorry for your mom's diagnosis, but glad you've found us and decided to post! Until you get responses from other members here, you may find some helpful information in this section of the main Breastcancer.org site, specially designed for those newly diagnosed and their loved ones: Breast Cancer 101

We hope it will help you understand test results, the individual characteristics of the cancer, treatments that are recommended for your mom, and more. Hope you find the information you need.

Let us know how you and your mom are doing. Wishing you the best!!

The Mods

Icietla

Welcome, nally18. I am so sorry your Mom is having to go through cancer treatment again.

If she had a full course of Radiation Treatment at that breast before, then it would not be customary practice to irradiate it any further. I believe mastectomy would be indicated for her case. Since her breast has invasive disease, I expect that would be modified radical mastectomy -- that is like "simple" mastectomy, but with some lymph node collection done in connection with the surgery. Mastectomy substantially reduces -- but does not eliminate -- the risk of local recurrence; however, it may not have any bearing on one's risk of distant recurrence.

http://www.breastcancer.org/treatment/surgery/mastectomy

http://www.breastcancer.org/symptoms/diagnosis/recurrent

Grade 2 classification indicates that the tumor tissue biopsied appears to be moderately aggressive. A couple of other things about the report tend to indicate that it might be be more than a little aggressive -- the Ki67 (which may not be a reliable reading, thus not necessarily a reliable indicator); and that there seem to be no Progesterone Receptors (in cases of Estrogen Receptor-positive disease, those are thought to moderate the tumor cells' processing of Estrogen).

I do not know the significance of the +2 indication on the HER-2 line. If your Mom's tumor tissue is considered HER-2 negative, she may have genomic assay testing done on the tumor tissue to be removed in her treatment surgery. When there is uncertainty as to the advisability of Chemotherapy, results of these type tests can help with the decision about Chemotherapy. If her tumor is HER-2 positive, she will need a term of HER-2 Targeted Treatment, the start of which is done in connection with Chemotherapy.

http://www.breastcancer.org/symptoms/diagnosis/genomic_assays

You will find much good information at (and from) this BCO page here__

http://www.breastcancer.org/symptoms/diagnosis

Is this biopsy report like her previous one -- is this breast cancer believed to be the same (from the same primary tumor source) as the breast cancer for which she has already had treatment?

Did she have Radiation Treatment before -- either before or following her Chemotherapy?

Did she have any (anti-) Hormonal Treatment following her other treatment/s? Was any continuing treatment recommended for her case?

In what Country does she live?