Some clinical trial options, Triple Neg, MBC

Moderators

* Posting per request, in case anyone may be interested in learning more.

Open Trials Women's Malignancies Branch, NCI/NIH

Contact: Alexandra Zimmer, MD

alexandra.zimmer@nih.gov

ONC201 (NCT03394027) https://www.clinicaltrials.gov/ct2/show/NCT03394027?term=onc201&draw=2&rank=12

Phase 2 trial with an oral agent taken once a week

Patients: HR positive BC or TNBC with metastatic disease

Requires: tumor biopsies by IR and measurable disease

Allows: Brain mets asymptomatic or treated >1 month; prior PD-1/L1

MEDI-O (NCT02484404)

https://www.clinicaltrials.gov/ct2/show/NCT02484404?term=olaparib&cond=Breast+Cancer&draw=4&rank=25

Phase 2 trial with Durvalumab (MEDI) IV q28 days with Olaparib PO twice daily

Patients: metastatic TNBC

Requires: tumor biopsies and measurable disease

No prior PARPi or PD-1/PD-L1

Brain mets stable >1 year allowed

Prexasertib (NCT02203513)

https://www.clinicaltrials.gov/ct2/show/NCT02203513?term=prexasertib&cond=breast+cancer&rank=1

Phase 2 with prexasertib given IV q2 weeks

Patients: metastatic TNBC

Requires: tumor biopsies and measurable disease

No brain mets history allowed