New test determines which VUS in BRCA2 gene are deleterious

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"Research test identifies BRCA2 gene mutations that lead to breast, ovarian cancers"

https://medicalxpress.com/news/2018-01-brca2-gene-...

http://www.cell.com/ajhg/newarticles

"Up until now, it has only been possible to establish that 13 inherited mutations in BRCA2 are pathogenic and known to cause cancer," says Dr. Couch. "In this study, we identified 54 that increase the risk of cancer. Similarly, 21 known neutral mutations that do not increase risk of cancer can now be expanded to 73. These findings may help patients and their health care providers make better decisions about how to deal with information obtained through genetic testing."

"In their study, Dr. Couch and his co-authors describe a laboratory-based test that can establish which inherited mutations called variations of uncertain significance in the BRCA2 gene are involved in cancer."