CHEK 2 vs BRCA 2

Elijahgirl

I was under the impression that CHEK 2 and BRCA 2 were the same now I am not sure. If not what’s the difference and which is worse

mustlovepoodles

No, they are different gene mutations. Chek2 is much more rare than BRCA2. As for which is worse, I think it's a toss up. Depending on your family history, your breast cancer risk can be equal.

I have Chek2 and PALB2 mutations, both of which are more rare than the BRCAs. They put me at 45%+ risk of BC, solidly in the BRCA2 risk territory. My DD24 also has both. Her BC risk is 58%+, almost the same risk as BRCA1.

Moderators

Hi Elijahgirl,

In addition to the helpful information mustlovepoodles shared above, you may want to check out the main Breastcancer.org site's page on Other Abnormal Gene Testing, as well as the section on Genetic Testing for lots of great information.

We hope this helps!

--The Mods