Mammaprint-who has had one?

Anonymous

Mammaprint-who has had one?

Anonymous

Just curious if anyone has used this test as oppose to the onco test? What was your result? Did it affect your decision on treatment.

Thanks, I just ordered mine. Waiting.

Meshell5324

Hi LizabethM,

My oncologist used a Mammoprint. It only has low or high risk results. Mine came back Low risk. He said I wouldn't receive any additional treatment benefits from chemotherapy. It took 7 days for the results to come in. Good luck, I hope yours comes back Low Risk.

Anonymous

Thank you for sharing your results! And, I'm glad your result took only seven days as I heard it could take up to two weeks.

Tappermom383

I didn't even realize my MO had sent my tissue out for a MammaPrint. I also came back low risk so I didn't have chemo.

M

gb2115

Yes, I had one. My Onc said she preferred it to Oncotype. And since that time, it has been added to the standards of care for the ASCO.

It came back as low risk luminal A. That meant, even though I had one positive axillary lymph node, we decided to not pursue chemotherapy because that would have added only 2% to the long term survival. So instead of 95% it dropped to 93% (or something like that.) I hope it was the right choice, I had a family member just have a metastatic recurrence after 17 years NED from the same type of breast cancer. But we are trying to predict the future and that's so hard when we are not at all in control of it.

Anonymous

Thank you, Ladies, for sharing your experiences!

I am hoping to have my mamma print back the end of this week so we can plan treatment,

TaRenee

I had one and it took close to a month to get results. That was thanks to my insurance, which decided I didn’t need it (I am going to fight that!) I was so frustrated and mad and scared it was all I could do not to call the doctor daily after the first week. In the end I was low risk and my MO said that chemo wouldn’t need to be done since I was so low risk. I’m on Tamoxifen now. I was so relieved to get the results back that I was rather shocked when I got my treatment plan.

So if it takes a little longer than you expect, try not to panic.

Anonymous

Thank you! I will be relieved when I finally have all the pieces of this bc puzzle. The mamma print will help with that! But, the waiting really is difficult.

teegirl

Has anyone had a high risk score on Oncotype and low risk on Mammaprint? I got a 35 on Oncotype but my MO didn't order a Mammaprint. I wish I would have insisted on it to compare. I'm stage 1, grade 2 IDC 100% estrogen positive, clear margins, no lymph node involvement and had bilateral mastectomy with reconstruction in July. Going through chemo (AC+T) now but dreading the next few months of this treatment. I want to do everything to reduce my risk of recurrence but concerned of the long term side effects of chemo on my body, not to mention dealing with the current side effects.

CIW

I had both mammaprint and oncotype done. Oncotype was 23, which is middle of the road, but my mammaprint came back in the high risk category, so I am glad I got it tested. It definitely helped finalize the decision to get chemo!

Anonymous

Just updating this in case anyone searches "mamma print" testing. Mine came back as "high risk" so I am currently doing the chemo that I had hoped to avoid. But, I am grateful for doing the Mammaprint because it helped solidify our treatment moving forward.

Garifalia

This topic is timely for me so I thought I'd share my experience. I just received my Oncotype DX result of 18, low end of intermediate risk. Oncologist stated I didn't need chemo because my result was less than 24. That appears to be his personal cut off point. But I was still concerned and pressed him on “why 24?" I was also concerned about my risk since my Mom battled breast cancer and died from it. He's not very empathetic with my concerns and brushed them off. But he did say I could have chemo if I wanted it. Who the heck WANTS it! I was going to get another opinion when he raised the option of ordering the MammoPrint test. That seemed like a fair and objective solution since the result is either Low Risk or High Risk. My husband was with me and he agreed so now we wait again for the result. This is so stressful.

TaRenee

I understand your concern. Breast cancer runs amok in my moms family so I was concerned about not having chemo when my MO said he didn’t think it would be necessary. Ihad the Mammoprint and came back low risk. The waiting for results was a hard time because I wanted answers and was ready to start treatment. I’m glad we waited. Mine came back low risk so we opted to go straight to Tamoxifen.

Garifalia

TaRenee—Thank you for your response and for understanding that I had a reasonable concern. I wish we would have known about the MammaPrint and did that test first. It would have spared a lot of personal angst and avoided such strained discussion with the oncologist. I’ll be fine with the result either way

EastcoastTS

Garifalia:

Similar situation here -- though mine came in at 14 (which I know is lower) but I wanted to be very sure with the NO chemo decision. My mom is a survivor and quite a bit of prostate cancer on maternal side of my family, which I've read may be related to ILC. (Which my mom and I both had, though all BRCA, etc., negative.)

Mamma came in low risk. I was happy in any case to have all the info I could. Why would we not want to know all we can???

Hope yours is low risk and you can rest easy with your decision. Good luck!

Garifalia

Thank you EastcoastTS! I tested negative for BRCA mutations too, but I developed BC at the same age as my mom so I think there’s a genetic link somewhere. She was ER+PR+ HER2 neg too. I’ll post my result when it comes in

ahw1971

My local Oncologist didn't want to,do a Mammaprint or Oncotype test saying that these tests should only be done if you don't want chemo. I went and had a 2nd opinion and she has ordered a Mammaprint and said if it came back as a Low risk, that I would not need to do chemo. I don't know how I feel about not doing chemo if the Mammaprint comes back low risk. Has anyone had their doubts about not doing chemo and has anyone had chemo with a Low risk result?

My Breast cancer is Invasive ductal Stage II Er+, Pr+, her2-. Grade 1, 1/5 sentinel nodes positive. Genetic testing was also negative

Mommabear0316

what is a mammoprint

ahw1971

it is a test done on the tumor to determine whether you are Low risk or High risk of your cancer returning. It also determines of you will need chemoor not.

keepthefaith

ahw, You might want to ask your first MO why they don't recommend chemo for you. I believe that the higher grade tumors respond better to chemo than the lower. I would be surprised if you were a high MP. Sometimes the risk of chemo out-weighs the benefit I was offered, but declined the MP test, after getting an intermediate onco-score. I think the MP is becoming more of a standard practice than it was when i was DX'd. Best wishes to you all!

ahw1971

thanks! My local MO want to do Taxotere and Cytoxan and I think I would feel better with chemo even if MP is Low risk

Anonymous

I think the grade of the tumor is a big factor with the onco and mamma print tests. I am Stage 1, no lymph node involvement and clear margins on a 1.8 cm tumor but my tumor grade was a "C" and the mamma print gave me a "high risk" score.

I think the Mammaprint is the latest generation of genetic testing but oncotype still seems to be more recognized.

Side by side, Mammaprint looks at 70 genes associated with recurrence when onco is less than 20. We requested the mamma print and it was about 2 weeks to hear back.

I have had one infusion of TC and my second infusion is next Wednesday. I'm glad we did Mamma because I did NOT want chemo and this was the deciding factor.

God bless you girls waiting on test scores. Once you get this last piece of the puzzle, you can move forward with a plan and that takes some anxiety away.

keepthefaith

lizabeth, you are so right about the anxiety diminishing as treatment is starting. I guess it makes us feel like we are fighting back and doing something positive. I hope you tolerate TC well. Drink plenty of water and stay as active as you can. The SE's are cumulative. ((HUGS)).

Anonymous

Keep the Faith-thanks for the heads up, I was wondering how the SEs are with each subsequent treatment. Love your log in name-God is Who sustains me. :-)

TaRenee

ahw1971 I was totally prepared for chemo. I think I actually wanted it because I just wanted to DO something. When my MO said no chemo I was rather taken aback. I asked questions, got more information, and finally just trusted the science and said okay. I’m thankful not to have to go through what so many others are with chemo, but sometimes I just hope I’m doing the right thing. I think I might mentally feel better with chemo but if it’s not going to be effective, why put myself through that

EastcoastTS

TaRenee:

I'm right there with you. Same sentiment. Didn't do chemo and was glad -- but then fear: should I have done chemo? I trusted science (and doctors), too.

FarAwayToo

To those of you who are uneasy with their decision not to do chemo based on Mammaprint result - keep in mind, that being Low Risk (Luminal A) doesn't just mean you DON'T NEED chemo, it also mean chemo may not be very effective for your cancer. So, while it may make you feel better mentally, it may be doing more damage to your body than helping you fight cancer. Simple cost-benefit analysis.

(take it from someone who is doing neoadjuvant chemo, and as part of the clinical trial I'm in my tissue was sent for MammaPrint - they don't need Luminal A in the study)

gb2115

TaRenee---I totally get what you said---I had those same thoughts. I actually found myself worrying about not getting chemo, and didn't understand why my MO's nurse was so happy for me to not get it. But yes, like FarAwayToo said, Mammaprint shows little benefit. And that's what my MO said...she said the risk of side effects outweighed the benefit for my luminal A cells.

Amelia01

I'm in Europe where ideas are a bit different than in the US and when asking about Mammaprint or Oncotype was told that they aren't really guidelines but in any case it is the tumor markers which decide for chemo or not. With any lymph node involvement they state that chemo is a must to ensure that rogue cells aren't elsewhere.

gb2115

Amelia01---that's interesting that they aren't using the Mammaprint more in Europe. It was invented in Europe--Netherlands I believe. You'd think it would be popular.

Things are definitely so different. I think here in the US, tumor markers aren't often routinely done unless the cancer is advanced or they are monitoring metastatic disease.