Radiation induced Breast Cancer Stem Cells - did you know?

macb04

I just saw info about this and started to research this. I was never told about this, were you ladies told about this and how it can increase the risks of aggressive Breast Cancer, and possibly Mets? This is unbelievably frightening.

Radiation-induced reprograming of breast cancer cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3413333/

Blocking the formation of radiation–induced breast cancer stem cells

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4116517/

Radiation induces the generation of cancer stem cells: A novel mechanism for cancer radioresistance

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5103903/

Induction of metastasis, cancer stem cell phenotype, and oncogenic metabolism in cancer cells by ionizing radiation

https://molecular-cancer.biomedcentral.com/articles/10.1186/s12943-016-0577-4

Radiation treatment generates therapy-resistant cancer stem cells from less aggressive breast cancer cells

http://onlinelibrary.wiley.com/doi/10.1002/cncr.27701/full

Cancer stem cells: Role in tumor growth, recurrence, metastasis, and treatment resistancehttp://journals.lww.com/md-journal/Fulltext/2016/09081/Cancer_stem_cells__Role_in_tumor_growth,.5.aspx

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694940/

Radiation promotes malignant phenotypes through SRC in breast cancer cellshttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4317785/

Radiation Acts on the Microenvironment to Affect Breast Carcinogenesis by Distinct Mechanisms that Decrease Breast Cancer Latency and Affect Tumor Type

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3110779/

Comparative study of the effects of different radiation qualities on normal human breast cells.

http://europepmc.org/abstract/MED/28946898

Assesment of radiation-induced secondary cancer risk in the brazilian population from left-sided breast-3D-CRT using MCNPX.

(PMID:28937271)http://europepmc.org/abstract/MED/28937271

marijen

I found this one in references from reading a link above. It has me worried. I had axilla radiotherapy for one positive node out of 12. Go to 6.6 to radiotherapy for nodal areas. It seems Mortality is worse for radiation.

https://www.ncbi.nlm.nih.gov/books/NBK11634/

Also read lung damage from radiation leads to lung mets. See here:

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signaling

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694940/

It's all very disturbing

Bosombuddy101

Very disturbing! I'm supposed to see a radiation oncologist next week and I'm not sure why? I hope to God my cancer wasn't close to the chest wall ( although this was never mentioned to me) and they recommend radiation ---won't know until next week. I read through the links and instead of coming to the conclusion that alternatives to radiation are warranted, the message I got is that doctors are trying to come up with novel drug therapies to be used in conjunction with radiation therapy. Right! All we need is more drugs in our system! Here is an excerpt from the article Marijen highlighted (the only part I understood as my eyes glazed over reading the rest!)

Radiation-induced lung damage promotes breast cancer lung-metastasis through CXCR4 signalinghttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC4694940/

Postoperative radiotherapy reduces the risk of both recurrence and mortality of breast cancer, and is nowadays standard treatment in the management of breast cancer after conservative surgery and after mastectomy to anticipate the high risk of relapse [1, 2]. Despite this progress, locoregional post radiotherapy relapses still occur in about 7-12.6% of the patients within the 5 years after treatment [3-5]. Relapses occurring within a preirradiated area are associated with an increased risk of local invasion, metastasis formation and poor prognosis compared to relapses occurring outside of the irradiated area [6]. Recent experimental evidence supports these clinical observations. In murine xenograft models, tumors developing within preirradiated beds are more invasive and metastatic compared to tumors growing outside irradiated beds, a condition also referred to as "tumor bed effect". Kuonen et al. investigated cellular and molecular mechanisms underlying the tumor bed effect in breast cancer by using the 4T1 triple-negative murine model mimicking local relapse after radiotherapy and identified the role of cancer cells and mobilized myeloid cells as a metastasis promoting mechanism in breast [7]. Also, radiation-induced stemness of residual breast cancer cells increased spontaneous lung metastasis [8].

Although these experimental models adequately address the impact of the local tumor bed effect, these in vivo models do not consider the incidental exposure of the cardiopulmonary region to ionizing radiation after postoperative radiotherapy. Incidental cardiopulmonary irradiation is clinically important since it increases the subsequent rate of ischemic heart disease and secondary lung cancer risk [9, 10]. Radiotherapy regimens for breast cancer have changed since these trials; the doses of up to 15 Gy to which the cardiopulmonary region was exposed are now generally lower [9, 10]. Nevertheless, in most women receiving contemporary radiotherapy protocols, the cardiopulmonary region receives doses of 1 to 10.9 Gy [11]. The estimated percentage of total irradiated lung volume may range from 2.7 to 17.6% in a study population receiving tangential radiation beams [12].

Lungs are a prime target organ for breast cancer metastasis but the impact of incidental radiation exposure on lung metastasis is unknown. In this paper, we experimentally and molecularly addressed whether preirradiation of lung epithelial cells impacts metastasis-associated cellular activities of well-characterized triple-negative human MDA-MB-231 and murine 4T1 breast cancer cells. Using a murine xenograft model, lung metastasis formation was evaluated after exposure of 10% volume of the right lung to clinically relevant doses of radiation.

marijen

I have upper lung fibrosis from radiation, I'm not TNBC but still the abovecould apply to all. I have a friend whose mother Is TNBC and just finished radiation about June. Last month she was dx with two cancerous growths in the lung on the radiated side.

CooieK

Bless you . Exactly what I was looking for. Thanks

macb04

I agree, I think they would like to have some kind of sucessful adjunctive drugs to erase the real risk of highly aggressive Induced Breast Cancer Stem Cells created by the RO's that can lead to even more deadly Mets. The truth of the matter is they actually have nothing that can even be slightly credited with removing that risk. Radiation side effects like Soft Tissue Radiation Fibrosis/ Increased Risks Pulmonary Fibrosis/Increased risks of Lymphedema, and more problems than I can easily list are bad enough to negatively impact our quality of life. Now we can not easily ignore an even worse side effect, that Radiotherapy may be strongly implicated in ending the lives of so many women each year who are afflicted with Metastatic Breast Cancer. This is unbelievably frightening. Is radiation therapy safe? Each woman needs to make an educated decision for themselves, weighing the real pros and cons, not just the ones the bc docs are willing to share. They don't have to live with the consequences, we do.

macb04

bump