Ibrance&Flasodex decreased hematocrite

cooperak

hi everyone,

My mother has bone mets 4 years. She was 3 years in xeloda but last year the CA 15/3 was increasing from 100 to 900. Then started Ibrance and flasodex 2 months go the CA 15/3 went to 500 in only 2 months, which is a great sign and the white cells are increasing. However the hematocirte decreased quite a lot to 25 then took 2 bed blood bottles went up to 30 but after a month and a half went again to 27.

The onc suggested to decrease the dose a bit since the TM is decreased 45% in 2 months and this should fix the HMC.

I read somewhere that Ibrance needs some time to stabilise the HMC. Any similar stories ?

Any suggestions?

cive

I'm not sure what you mean by HMC or hematocirte, since neither of these are done in my blood work.  I saw your posting on the fas/Ibrance thread but didn't answer since I don't know.  I have HCT, is that what you are referring to?  If so my HCT is/has been low normal, but I've had trouble with WBC.

cooperak

thanks for your reply.

My mother had issues the first month with WBC but now it looks like that are going up again.

Yes I am referring to HCT. Since she started Ibrance it went quite low. To high out of normal. Around 27% at the moment.

She is taking Ibrance125mg 3 weeks 1 week off.

are you taking the same ?

What do you do for the WBC?

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cive

I was taking the same 125 mg, but because of low white counts it's worked out to 3 weeks on 2 weeks off because 2nd cycle is delayed a week, then 3 weeks on again.  My HCT is consistently in the low 30s.