Pathology test showed ILC & E-Cadherin showed IDC

LCY

HI. I am new to the group and I am still learning about breast cancer. I have undergone total mastectomy with sentinel lymph node dissection last June 28, My cancer was Stage 1A, nuclear grade 1. Prior to surgery, a core needle biopsy was done which came back with the results of Invasive Lobular Cancer (ILC). The Pathology report done after the mastectomy correlated the same findings - ILC, but suggested that E-Cadherin test be done. The E-Cadherin test results came back with Invasive Ductal Carcinoma. The tumor is only 1.1 cm and is ER+, PR+, HER2-.

Initially, I was told that I might not need to undergo chemotherapy anymore due to the low stage. None of the lymph nodes tested/removed indicated cancer. However, due to the results of the E-Cadherin test, I am now told that there is still the possibility of undergoing chemo.

What does this mean? And what is the difference in treating ILC, IDC, or mixed type cancer?

kira1234

I'm not sure why being IDC rather than ILC would change chemo for stage 1. I'd request the oncotype test or the mammaprint test be done

Mucki1991

Hi, I too have mixed mine is, Invasive high-grade mammary carcinoma with mixed ductal, lobular and micropapillary features, node-positive. I'm not sure either why it would change whether or not you would chemo. I am curious as to how common mixed cancers are? I am meeting with my onc for the first time next week and I eager to find out his views on this. I had my BMX on the 14th so I'm really just getting to the treatment stage now.

letsgogolf

I think it is fairly common to have mixed tumors.. Mine was IDC with Lobular features, grade 1. I have been told that 50% of this type of tumor involve 1 node only and that they are less likely to cause mets. They also have a higher rate of second primary tumors.

beach2beach

Not sure LCY if you are on here any longer, but I was initially diagnosed on biopsy as IDC. After surgery, pathology came back as ILC so they had to check the nodes with a different type of stain to make sure it had not spread. My pathology also came back as well with DCIS and LCIS as well. All in a 7mm tumor.