ER-,PR+<50%,HER2-

Calgrl

I am 51 early stage breast cancer, grade 3, lumpectomy, 8 nodes removed no vascular invasion, 4 rounds of chemo and 38 rounds of radiation. I also had my ovaries removed they want me on AI. The side affects are awful for me not sure it will even help. Anyone else out there who has decided not to take this med with this receptor profile. I have only found two people we need more info.

Siegelinde

• hi,

I am er-, progesterone 30% positive. However I am Her2+

No nodes. Bony mets.

I have so far chosen not to take tamoxifen. Have tried it for a few days. Just very scared of side effects. Have had fatigue and mood issues as it is, and brief tries with Effexor, Cymbalta left me exhausted.

Oncologist mentioned AI s may be recommended in future. Not sure I understand use of anti hormone treatment in hormone negative tumor treatment, but it does seem to be standard of care, and probably for good reasons.

Hope to hear from more estrogen negative patients.

Thank you for opening up the topic

cdv4251992

I am also only PR+ (4/8) and have been searching for info on this and others in my situation. There's not much out there. My MO wants to start either Tamox or an AI depending on my status once Taxol treatments are done. I've found one small study that did not seem to show much benefit for PR+ only. I'm not sure the benefits outweighs the SE's or how my quality of life might be affected by taking these types of meds.

Her feeling is that even if I'm ER- and perimenopausal or become menopausal (I'm 47 but have had intermittent periods for the last couple of years), my body will compensate for the loss of hormones and fat will produce estrogen, which she says needs to be suppressed because it will somehow affect the progesterone ( she was not really clear on the point she was trying to make and it was only 3 weeks afterward my DIEP surgery when we talked about it.).

What I would like to do is to concentrate on losing a good 20-25 lbs after I am done and maintain that and then talk about taking something. It seemsto me that the extra weight I have is more of a factor for what the MO is talking about than my hormone status. And being leaner will help with my future risk of developing a different type of cancer than taking a medication which, it sounds like, will cause me to gain more weight, or at the very least, have difficulty losing any.

I'm interested in following this thread to hear experiences from others with the same/similar profile.