Lines of treatment

Batfax

All,

I'm a lurker who rarely posts, but I feel compelled to solicit the input of some of you who have been around the block with treatments. My wife was diagnosed stage 4 with mets in the liver and nodes throughout the abdomen a little less than two years ago. Since then we've tried taxol (worked for about 8 months), Ibrance (maybe two months, if at all), the exemestane + everolimus + ribociclib trial (maybe two months, if at all), Xeloda (maybe five months) and now Halaven. Unfortunately, it seems as if the Halaven either never worked or has stopped working after only about one months. Her tumor markers are rising slightly, and they've always been a reliable indicator of progression. Additionally, she's had slight ascites and her abdominal nodes/liver mets have been causing a lot of abdominal/gastointestinal discomfort and she's dropped a lot of weight off an already small frame.

So, I suppose what I'm looking for is any insight folks have on trying this many lines of treatment. If Halaven has failed, she's going to be moving on to her sixth line. And from what I've been able to research, there's very little data on the efficacy of this many lines and it appears that each successive line of treatment has a lower chance of success. Looking for a little reassurance or some insight. Thanks.