Sulfonylureas - increased Cardiovascular Events and Death

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http://www.practiceupdate.com/c/52332/1/6/?elsca1=...

Sulfonylureas Are Associated With Increased Risks of Cardiovascular Events and Death

• This meta-regression analysis included 19 studies investigating the association between sulfonylureas and cardiovascular events or mortality, identifying 36 relative risks. Of these relative risks, metformin was the comparator in 75% and death was the outcome in 67%. The relative risk was 13% higher when the comparator was metformin, 20% higher when death was the outcome, and 7% higher when a study design–related bias was present.
• These results find that sulfonylureas are associated with increased cardiovascular and mortality risk in the majority of studies without major design-related bias, highlighting the importance of the use of appropriate design and analytical tools for accurate cardiovascular safety assessments.