ER 100% positive, PR 10% positive, HER2 equivocal. Gr 3

DisneyFan2017

I had surgery on Jan 13. Removed tumour in left breast approx 2.8 cm. sentinel node was enlarged and positive for cancer so ALND was complete ( 6/14 nodes positives) the lymph vascular is positive. I have oncology on Feb 24.

Anyone else have similar pathology? If similar what type of therapy regiment did you receive?

Thanks

L

BarredOwl

Hi DisneyFan2017:

Welcome. You mentioned in the title of your thread that HER2 status was "equivocal". In general, if HER2 test results are initially "equivocal", then under guidelines from the American Society of Clinical Oncologists (ASCO), further "reflex" testing should be performed by another method. For example, if found to be "equivocal" by IHC (IHC 2+), then reflex testing by (F)ISH would be done. Be sure to obtain a copy of your pathology report and any addenda or supplement with the results of further HER2 testing.

If by further testing, the tumor is found to be HER2-negative, then with a 2.6 cm IDC and six positive nodes, it is likely that chemotherapy will be recommended. The selection of chemotherapy regimen in the particular case is a question for a trained medical oncologist, in light of clinical (age, co-morbidities) and pathologic factors.

If by further testing, the tumor is found to be HER2-positive, then you would be "triple-positive" (ER+, PR+, HER2+) and would likely receive a recommendation for chemotherapy plus HER2-targeted therapy (e.g., trastuzumab (Herceptin), and in some cases (USA), both trastuzumab and pertuzumab (Perjeta)). There is an active group for those with "triple-positive" disease here:

Triple Positive Group: https://community.breastcancer.org/forum/80/topics/764183?page=999#idx_29942

Regardless of HER2 status, with hormone receptor-positive disease, endocrine therapy is likely to be recommended, for example, tamoxifen; an aromatase inhibitor ("AI"); tamoxifen or an AI plus ovarian suppression.

Burstein (2016), ASCO Guideline Update re Ovarian Suppression: http://ascopubs.org/doi/full/10.1200/JCO.2015.65.9573

(Free pdf version under "PDF" tab)

Best wishes as you move forward with treatment.

BarredOwl