PATH report question

wendymk2016

Can any one help me for my PATH report showing as following:

1)

Primary Tumor (Invasive Carcinoma) (pT): pT1a: Tumor > 1 mm but <= 5 mm in greatest dimension

QUESTION******************** my tumor size is 2mm, Due to nurse, there are not too much tissue can be used for onco score test? My FISH test even failed, not sure if it is caused by this reason.

Modifier: (sn): Only sentinel node(s) evaluated. If 6 or more nodes (sentinel or nonsentinel) are removed, this modifier should not be used.

QUESTION********************Three SN are taken, the other two are negative. The first one has the following found, will this affect my treatment plan & prognosis?

Category (pN): pN0 (i+): Malignant cells in regional lymph node(s) no greater than 0.2 mm and no more than 200 cells (detected by H&E or IHC including ITC)

2)

MARGINS

Invasive Carcinoma: Margins uninvolved by invasive carcinoma

Distance from Closest Margin: Distance (specify in mm): 1

Closest Uninvolved Margin: Posterior

Ductal Carcinoma In Situ (DCIS): Margins uninvolved by DCIS (DCIS present in specimen)

Distance of DCIS from Closest Margin (mm): Distance is < 1 mm

Closest Uninvolved Margin(s): Posterior

QUESTION******************** I did simple mastectomy, for this margin, do i need radiation?

3)

QUESTION******************** MY HER-2 TEST via FISH failed, can anyone tell why?

IHC test shows 2+.

Under this situation, is there any other way to do HER-2 test?

Antibody & Clone	Percent Positive & Intensity	Interpretation
Estrogen Receptor - 6F11	100% Positive Cells Strong	Positive
Progesterone Receptor - 16	0% Positive Cells	Negative
KI-67 - MM1	8% Positive Cells	Low

Material: Block D5

Population:Tumor Cells

Probe	Result	HER2/CEP17 Ratio
HER2-NEU FISH	Failed

I really appreciate your feedback!

Wendy

farmerlucy

Wendy - I think the oncotype people need around 3 mm to test. You might send them a question. They get back to you the same day. I can't speak to the node, but I know a micromet will notchange your stage.

Hopefully someone else will come along soon with more answers.

wendymk2016

Lucy Thank you very much for your input, I will meet my MO next week. Hopefully I can find out all the answers. Thanks.