Trigger found that causes TNBC to become metastatic?

gymgirl1940

A protein MnSOD has been identified that triggers a change in TNBC primary cancer cells to become metastatic. This protein is normally needed as an antioxidant to help prevent inflammation that might trigger DNA damage and create cancer, heart disease, and accelerated aging to name a few. Some people are apparently born with a deficiency of MnSOD and may be prone to cancer initiation. MnSOD expression is decreased during the initial stages of cancer development. However, as the cancer advances, MnSOD expression increases and such high MnSOD levels are typically observed in triple negative breast cancer patients. In fact, it has been shown that less aggressive tumors, when artificially made to increase MnSOD protein levels, adopt an aggressive behaviour. One study shows that the amount of MnSOD levels in the tumor cell determines the predominant reactive oxygen species that will tell the tumor cells whether to stay put or to transform into an invasive form that is capable of moving to distal parts of the body (http://medicalxpress.com/news/2016-11-scientists-b...). As part of their earlier study, the team had shown a novel strategy of targeting this enhanced MnSOD expression and therefore its activity using other FDA-approved drugs to make the aggressive tumors more sensitive to conventional anti-cancer drugs. They also showed that this strategy would re-sensitize patients who develop resistance to conventional breast cancer drugs such as Docetaxel or Doxorubicin.

It seems that taking supplements such as Superoxide Dismutase/Gliadin Complex (GliSODin®) and eating foods that contain MnSOD would be a good thing to prevent primary cancers and other diseases but would enhance or expedite the progress towards metastasis if cancer develops. This process may be similar to prostate cancer where patients with prostate cancer routinely present with low levels of testosterone (may be a cause of PC) but are treated by suppressing testosterone once a cancer develops.

Can anyone with a more technical background help with recommendations with regards to consuming MnSOD?