Anastrozole vs. Exemestane - Effectiveness in treating ILC

CCS648
CCS648 Member Posts: 41
edited November 2016 in ILC (Invasive Lobular Carcinoma)

Is anyone familiar with this study? I'd love to hear from John Smith ...

It was presented at ASCO 2016.

Outcomes of invasive ductal (ID) or invasive lobular (IL) early stage breast cancer in women treated with anastrozole or exemestane in the Canadian cancer trials Group MA.27

It essentially seems to indicate that anastrazole is somewhat more effective than exemestane in preventing recurrence in ILC.

· Share on FacebookShare on Twitter

Comments

  • LRGinger
    LRGinger Member Posts: 30
    edited October 2016

    thank you for posting this! My MO is recommending a change from anastrozole to exemestane due to side effects. I will share this with him.


    · Share on FacebookShare on Twitter
  • Meow13
    Meow13 Member Posts: 4,859
    edited October 2016

    My onco chose anastrozole as my first treatment then when it became unbearable I switched to exemestane. I think anastrozole is very effective.

    · Share on FacebookShare on Twitter
  • Smurfette26
    Smurfette26 Member Posts: 730
    edited October 2016

    Anastrozole was my Oncologists first choice for ILC.

    · Share on FacebookShare on Twitter
  • Lily55
    Lily55 Member Posts: 3,534
    edited October 2016

    The difference is not huge.  I started on letrozole and was like an old lady unable to get out of chairs on my own....went on EXemestane, stopped that for 8 months due to side effects, started taking a naturopathic anti inflammatory (Boswellia) for two months and then tried Anastrozole, lasted 3 weeks, it paralysed my colon, could not go to the toilet at all, even with enemas, went off for 2 weeks then back on Exemestane, now with much fewer side effects as I am still taking Boswellia.

    I did the RGCC test in Greece and it showed that Exemestane IS still working on the cáncer cells I have circulating in my blood stream

    · Share on FacebookShare on Twitter
  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2016

    I began with Tamox, then when chemo put me in menopause I was switched to Arimidex,which gave me awful side effects. I'm now doing well on Aromasin (exemenstane).

    · Share on FacebookShare on Twitter
  • Meow13
    Meow13 Member Posts: 4,859
    edited November 2016

    claire, I had the same experience. But I did have side effects with exemestane and finally quit. I got somewhere between 3.5 and 4 years total taking them. I think they offer excellent protection especially with er and pr positive.

    · Share on FacebookShare on Twitter
  • Anonymous
    Anonymous Member Posts: 1,376
    edited November 2016

    I'm hoping to hang in with exemestane till I don't have to take it anymore. But according to my MO, she thinks maybe rest of my life, the way the research seems to be pointing.

    · Share on FacebookShare on Twitter
  • CCS648
    CCS648 Member Posts: 41
    edited November 2016

    My oncologist agrees that's the way the research is heading, but worries that we don't know enough about the long-term use of AI's for women starting under 50. He thinks that the mortality rates may rise from cardiac events, as well as the potential for mental deterioration.

    He made the comparison to Hormone Replacement Therapy, which was thought to be the best thing since peanut butter, until it turned out it seems to have contributed to breast cancer.

    Definitely a double-edged sword.

    · Share on FacebookShare on Twitter

Categories