Significance of TP53 R213, Various Amplifications?

Anonymous

Significance of TP53 R213, Various Amplifications?

VLH

There was a conflict / discordance between my core needle biopsy results & solid tumor pathology reports so my MO ordered a Foundation One Molecular test. Both pathology reports agreed that ER / PR are negative, but the CNB showed HER2+ while the solid tumor analysis showed HER2-. Since treatment options and prognosis are worse for triple negative, we'd hopeed for HER2+ status, but ERBB2 showed no mutation so I'm triple negative. My MO appointment focused on that issue, but I'm having trouble finding meaningful information about other mutations that were identified. I'm fairly adept at research, but many of the online articles unearthed provide zero help as far as how the alterations might affect my prognosis. My copy of the huge report was missing several pages of footnotes, including articles related to TP53, which probably wouldn't interest most patients, and I've requested those.

Can anyone recommend sources that explain the mutations as they relate to clinical outcome vs. tons of jargon with no practical information? For example, I learned that reducing carbohydrates might be helpful in terms of recurrence for those with IGFR1R mutation. I also learned that the gene is associated resistance to therapy. That type of practical information is the exception.

Also, many articles refer to tumor subtypes (luminal A or B, basal-like). I know most triple negative tumors are basal-like, but don't recall anything about it on the pathology report. How does one learn their subtype? Thanks!