Advanced Breast Cancer-Need Advice(Perjeta)

Anonymous

Advanced Breast Cancer-Need Advice(Perjeta)

prasadp

Hi All,

My mother is undergoing breast cancer treatment (Her2+) . Initially when her FISH test was conducted ,her score was 2+ (genomic amplification of Her2 gene) .

Even after taking 10 rounds Herciptine chemo , it didnt help to shrink the breast ,my mother still had a feeling of heaviness of lump and spots were seen on the breast .

So doctors decided to start Perjeta cycles with Herceptine and Docetaxel. But even now , we are not seeing much improvement after taking 3 cycles of Perjeta , we do see spots on the breast and doctors mentioned it seems it is growing.

Question : Why cancer is not responding to Her2 targerted drugs like perjeta ? Do we have any other options ? what kind of treatment would you suggest ?

Moderators

Hi prasadp, welcome to Breastcancer.org. We're sorry for your mom's diagnosis, but glad you found us and decided to reach out.

Until other members post here with their wonderful support and advice, you may want to take a look at the following articles from our main site:

Treatments for Hormone-Receptor-Positive Breast Cancer

Targeted Therapies

Why Do Some HER2-Positive Breast Cancers Not Respond to Perception?

We hope this helps! Please let us know how everything is going.

Kind wishes,

The Mods

prasadp

Thanks for your reply ! Will be looking forward for member posts .

youngjane52

Hi, I don't have answers for you, just wanted to let you know my treatment regime. I am stage 3 triple positive invasive lobular ca. I received 6 rounds 3 weeks apart of taxotere, perjeta, and herceptin. I then had bilateral mastecomy with no evidence of cancer in either breasts or lymph nodes. I continued with herceptin every 3 weeks for a total of 15 treatments, and am now on arimidex for 5 years. Did your mother seek a 2nd opinion for her treatment? No Dr. should EVER be offended if you seek a 2nd opinion, as no one will fight for you harder than yourself. Hugs to you both.